research use only

Sovilnesib (AMG 650) KIF18A Inhibitor

Name: Sovilnesib (AMG 650)
Brand: Selleck Chemicals
SKU: E1180
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1180

AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.

Chemical Structure

Molecular Weight: 564.65

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.92%

99.92

Related Targets	Akt Microtubule Associated Wnt/beta-catenin HSP PKC Integrin Bcr-Abl Actin FAK ROCK Dynamin PAK MLCK MPS1 PORCN Gap-Junction Cardiac Myosin KSP TACC3 Tight Junction Protein Piezo Channel Myosin
Related Products	GSK923295 Ispinesib (SB-715992) SB743921 HCl Monastrol ARQ 621 VLS-1488(KIF18A-IN-6 ) SB-743921 GW406108X AM-9022 Litronesib Paprotrain VLS-1272 Filanesib hydrochloride H-Cys(Trt)-OH KIF3A Antibody [H4E10] Eg5 Antibody [K11B11] K 858 KIF4A/KIF4 Antibody [N7K8] KIF1A Antibody [F10B19] KIF5B + KIF5C Antibody [B24G18] BTB-1

Chemical Information, Storage & Stability

Molecular Weight	564.65	Formula	C₂₆H₃₄F₂N₆O₄S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2410796-79-9	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AMG 650			Smiles	CC1=CC(=NC(=N1)N2CCC(F)(F)CC2)NC(=O)C3=C(C=C(N[S;v6](=O)(=O)CCO)C=C3)N4CCC5(CC4)CC5

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (177.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (8.86mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.33mg/ml (0.58mM)	Taking the 1 mL working solution as an example, add 50 μL of 6.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	kinesin-like protein KIF18A ^[1]
References	[1] https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.TPS5600

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06084416	Recruiting	High Grade Serous Adenocarcinoma of Ovary\|Fallopian Tube Cancer\|Primary Peritoneal Carcinoma\|Chromosomal Instability	Volastra Therapeutics Inc.	April 4 2024	Phase 1
NCT04293094	Completed	Advanced Solid Tumors	Volastra Therapeutics Inc.\|Amgen	March 11 2020	Phase 1

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Handling Instructions

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