(20S)-Protopanaxatriol

For research use only.

Catalog No.S3617 Synonyms: g-PPT, 20(S)-APPT

(20S)-Protopanaxatriol Chemical Structure

CAS No. 34080-08-5

(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).

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Biological Activity

Description (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
In vitro

Protopanaxtriol (Ppt) is a neuroprotective ginseng extract. Ppt exerts its antioxidative activity via several mechanisms, such as direct scavenging of free radicals and restoration of succinate dehydrogenase activity. These mechanisms may contribute to its potent antioxidative and putative neuroprotective activities[1]. Ppt exhibited strong noncompetitive inhibition towards UGT1A1 and competitive inhibition towards UGT2B7. The inhibition kinetic parameters (Ki) were calculated to be 8.8 and 2.2 μM for UGT1A1 and UGT2B7, respectively[2]. PPT could repress the viability and invasiveness, and promote the apoptosis in A549 and SK-MES-1 cells.

In vivo Protopanaxtriol (Ppt) is shown to reduce learning and memory impairment associated with Alzheimer's diseases and protect against 3-NP-induced oxidative stressin the rat model of Huntington's disease, which is associated with its anti-oxidant activity. Ppt prevents short- and long-term memory impairments induced by chronic sleep deprivation probably through antagonizing oxidative stress in the cortex and hippocampus[1].

Protocol

Cell Research:[3]
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  • Cell lines: A549 cells or SK-MES-1 cells
  • Concentrations: 0, 0.4, 4 or 40 uM
  • Incubation Time: 48 h
  • Method: A549 cells or SK-MES-1 cells are seeded in 96-well plates (3×103 cells/well), and then treated with different concentration of PPD, PPT, G-Rg3 or G-Rh2 (0, 0.4, 4 or 40 μM) for 48 h, with cisplatin (2 ug/ml) as a positive control and 0.1% DMSO as a blank control. Then these cells are collected and detected the viability by the cell-counting Kit-8 (CCK-8) assay.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: ICR male mice
  • Dosages: 20μmol/kg, 40μmol/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (199.27 mM)
Water Insoluble
Ethanol ''95 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 476.73
Formula

C30H52O4

CAS No. 34080-08-5
Storage powder
in solvent
Synonyms g-PPT, 20(S)-APPT
Smiles CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)O)C)O)C)O)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID