For research use only.
Catalog No.S3617 Synonyms: g-PPT, 20(S)-APPT
CAS No. 34080-08-5
(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
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|Description||(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).|
Protopanaxtriol (Ppt) is a neuroprotective ginseng extract. Ppt exerts its antioxidative activity via several mechanisms, such as direct scavenging of free radicals and restoration of succinate dehydrogenase activity. These mechanisms may contribute to its potent antioxidative and putative neuroprotective activities. Ppt exhibited strong noncompetitive inhibition towards UGT1A1 and competitive inhibition towards UGT2B7. The inhibition kinetic parameters (Ki) were calculated to be 8.8 and 2.2 μM for UGT1A1 and UGT2B7, respectively. PPT could repress the viability and invasiveness, and promote the apoptosis in A549 and SK-MES-1 cells.
|In vivo||Protopanaxtriol (Ppt) is shown to reduce learning and memory impairment associated with Alzheimer's diseases and protect against 3-NP-induced oxidative stressin the rat model of Huntington's disease, which is associated with its anti-oxidant activity. Ppt prevents short- and long-term memory impairments induced by chronic sleep deprivation probably through antagonizing oxidative stress in the cortex and hippocampus.|
|In vitro||DMSO||95 mg/mL (199.27 mM)|
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Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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