SW-044248

Catalog No.S6747

For research use only.

SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.

SW-044248 Chemical Structure

CAS No. 522650-83-5

Purity & Quality Control

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Biological Activity

Description SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.
Targets
Topo1 [1]
In vitro

SW044248 is selectively toxic for some NSCLC cell lines. SW044248 rapidly inhibits transcription, translation and DNA synthesis in sensitive cells but not insensitive cells. The acute transcriptional response to SW044248 correlates with the response to agents that cause DNA damage[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: NSCLC cell lines
  • Concentrations: --
  • Incubation Time: 96 h
  • Method:

    Cell viability assay

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 421.52
Formula

C22H23N5O2S

CAS No. 522650-83-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(C(=O)NC1=CC=CC=C1OC)SC2=NC3=C(C4=CC=CC=C4N3CC)N=N2

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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