Name: S-(+)-Ketoprofen
Brand: Selleck Chemicals
SKU: S5192
Availability: InStock
Rating: 5 (1 reviews)

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Quality Control

Batch: S519201 DMSO]51 mg/mL]false]Ethanol]51 mg/mL]false]Water]Insoluble]false Purity: 99.93%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.93

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant Histamine Receptor
Other COX Inhibitors	NS-398 (NS398) Paeoniflorin (NSC 178886) Xanthohumol Lumiracoxib Bufexamac Ginsenoside Rd Etoricoxib Oroxin B Nimesulide (-)-Epicatechin gallate

Solubility

In vitro
Batch:

DMSO : 51 mg/mL (200.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 51 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight	254.28	Formula	C₁₆H₁₄O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	22161-81-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Actron, (S)-Ketoprofen, Dexketoprofen			SMILES	CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	COX-1 (Cell-free assay) 1.9 nM COX-2 (Cell-free assay) 27 nM
In vitro	Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining.
In vivo	Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice.
References	[1] https://pubmed.ncbi.nlm.nih.gov/17964538/ [2] https://pubmed.ncbi.nlm.nih.gov/8971650/ [3] https://pubmed.ncbi.nlm.nih.gov/8536666/ [4] https://pubmed.ncbi.nlm.nih.gov/12772856/ [5] https://pubmed.ncbi.nlm.nih.gov/8706245/ [6] https://pubmed.ncbi.nlm.nih.gov/10841807/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-07)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07574099	ACTIVE_NOT_RECRUITING	Maxilla; Tooth Loss / Rehabilitation	University of Belgrade	2019-03-01
NCT05463133	RECRUITING	Chronic Granulomatous Disease	National Institute of Allergy and Infectious Diseases (NIAID)	2022-07-08	PHASE1; PHASE2
NCT07498257	ACTIVE_NOT_RECRUITING	Posttraumatic Stress Disorder (PTSD)	Medical University of South Carolina	2026-05-06
NCT07055087	NOT_YET_RECRUITING	Parkinson's Disease	University Hospital Tuebingen	2025-12	PHASE2
NCT07095608	RECRUITING	Oral Cancer; Squamous Cell Carcinoma	New York University	2025-09-01
NCT07581704	RECRUITING	Multiple Myeloma	Christopher Strouse	2026-06-01	PHASE1

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S-(+)-Ketoprofen COX inhibitor

Chemical Structure

Molecular Weight: 254.28