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Sodium salicylate NF-κB inhibitor

Cat.No.S3137

Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.
Sodium salicylate NF-κB inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 161.11

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Quality Control

Batch: S313701 DMSO]32 mg/mL]false]Water]32 mg/mL]false]Ethanol]Insoluble]false Purity: 99.98%
99.98

Chemical Information, Storage & Stability

Molecular Weight 161.11 Formula

C7H6O3.Na

 Storage (From the date of receipt)
CAS No. 54-21-7 Download SDF Storage of Stock Solutions

Synonyms 2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt Smiles C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

Solubility

In vitro
Batch:

DMSO : 32 mg/mL ( (198.62 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 32 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
NF-κB [1]
In vitro

Sodium salicylate acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. This compound inhibits the activation of NF-kappa B, and also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] It also induces apoptosis via p38 MAPK and inhibits TNF-induced JNK/stress-activated protein kinase activation. [2]
References

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