Sodium salicylate

NF-κB inhibitor

Synonyms: 2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt

Home NF-κB NF-κB inhibitor Sodium salicylate

For research use only.

Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.

Sodium salicylate Chemical Structure

Sodium salicylate Chemical Structure

Molecular Weight: 161.11

CAS No. 54-21-7

Purity & Quality Control

Batch: S313701 DMSO]32 mg/mL]false]Water]32 mg/mL]false]Ethanol]Insoluble]false Purity: 99.98%
99.98

Sodium salicylate Related Products

Signaling Pathway

NF-κB Signaling Pathways

NF-κB Signaling Pathway

Mechanism of Action

Description Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.
Targets
NF-κB [1]

In vitro
In vitro

Sodium salicylate acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. Sodium salicylate inhibits the activation of NF-kappa B, and also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Sodium salicylate also induces apoptosis via p38 MAPK and inhibits TNF-induced JNK/stress-activated protein kinase activation. [2]
  • https://pubmed.ncbi.nlm.nih.gov/8052854/
  • https://pubmed.ncbi.nlm.nih.gov/9096313/

Chemical Information

Molecular Weight 161.11 Formula

C7H6O3.Na
CAS No. 54-21-7 SDF Download Sodium salicylate SDF
Smiles C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

Storage and Stability

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (198.62 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 32 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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