For research use only.

Catalog No.S7934

1 publication

SR9243 Chemical Structure

Molecular Weight(MW): 626.62

SR9243 is a potent and selective LXR inverse agonist.

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Selleck's SR9243 has been cited by 1 publication

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Biological Activity

Description SR9243 is a potent and selective LXR inverse agonist.
LXR [1]
In vitro

In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments. [1]

In vivo In Ob/Ob mice fed a high-fat diet, SR9243 (60 mg/kg, i.p.) inhibits LXR-dependent lipogenic enzyme gene expression and tumor growth. [1]


Cell Research:[1]
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  • Cell lines: DU-145, SW620, HOP-62, PC3, HT-29, and NCI-H23 cancer cells
  • Concentrations: 100 nM
  • Incubation Time: 96 h
  • Method: Cells are cultured in 96 well plates and treated with designated amounts of SR9243 for 96 hr in media containing 1% FBS and antibiotics. Cell-viability is assessed using the Cell-titre 96 kit according to the manufacturer’s guidelines. Cell culture media is supplemented with oleate, stearate and palmitate dissolved in methanol to a concentration of 25 mM. 25 mM stocks are then diluted 10 fold in PBS containing 0.9% BSA. Lipid stocks (100X) are stored at −20° until needed.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mice bearing SW620, DU-145, or LLC tumors
  • Dosages: 60 mg/kg, once daily
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 98 mg/mL warmed (156.39 mM)
DMSO Insoluble
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 626.62


CAS No. 1613028-81-1
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC(=C(C(=C1)C)[S](=O)(=O)N(CCC2=CC=CC(=C2)Br)CC3=CC=C(C=C3)C4=CC(=CC=C4)[S](C)(=O)=O)C

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% DMSO % % Tween 80 % ddH2O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID