SCR130

Catalog No.S9775

For research use only.

SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.

SCR130 Chemical Structure

CAS No. 2377858-38-1

Purity & Quality Control

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Biological Activity

Description SCR130 is a novel DNA repair inhibitor with IC50s of 14 μM in Reh cells and 2 μM in Nalm6 cells. SCR130 specifically inhibits DNA Ligase IV‐mediated joining with minimal or no effect on Ligase III and Ligase I mediated joining.
Targets
DNA repair [1]
(in Nalm6 cells)
2 μM
In vitro

SCR130 is a new a novel inhibitor of nonhomologous end-joining (NHEJ) by leading to loss of mitochondrial membrane potential leading to cell death by activating both intrinsic and extrinsic pathways of apoptosis, showing the IC50 of 14.1 μM in Reh cells and 2.2 μM in Nalm6 cells.<sup><a class="sref" href="#s_ref">[1]</a></sup>

Protocol (from reference)

Cell Research:

<sup><a class="sref" href="#s_ref">[1]</a></sup>

  • Cell lines: Reh, HeLa, CEM, Nalm6 and N114 cells
  • Concentrations: 0.1, 0.5, 1, 2, 5, 10, 50, and 100 μM
  • Incubation Time: 48 h
  • Method:

    Effect of the inhibitors on Nalm6, Reh, HeLa, CEM, and N114 cell lines was determined by Trypan Blue dye exclusion assay

Solubility (25°C)

In vitro

DMSO 84 mg/mL
(200.81 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 418.30
Formula

C19H13Cl2N3O2S

CAS No. 2377858-38-1
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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