Sodium Picosulfate
Catalog No.S4020
Molecular Weight(MW): 481.41
Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.
Purity & Quality Control
Biological Activity
| Description | Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion. |
|---|---|
| In vitro |
Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1] |
| In vivo | Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. [2] Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. [3] Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal. [4] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 96 mg/mL (199.41 mM) |
|---|---|---|
| Water | 96 mg/mL (199.41 mM) | |
| Ethanol | 3 mg/mL (6.23 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 481.41 |
|---|---|
| Formula | C18H15NO8S2.2Na |
| CAS No. | 10040-45-6 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03698474 | Completed | Colonoscopy | Tomas Bata Hospital Czech Republic|Faculty Hospital Kralovske Vinohrady | October 25 2018 | Phase 4 |
| NCT03698474 | Completed | Colonoscopy | Tomas Bata Hospital Czech Republic|Faculty Hospital Kralovske Vinohrady | October 25 2018 | Phase 4 |
| NCT03593252 | Not yet recruiting | Colostomy Stoma|Ileostomy - Stoma|Jejunostomy Stoma|Hirschprung''s Disease|NEC|Inflammatory Bowel Diseases|Meconium Ileus|Bowel Obstruction | McMaster University | September 1 2018 | Not Applicable |
| NCT03593252 | Not yet recruiting | Colostomy Stoma|Ileostomy - Stoma|Jejunostomy Stoma|Hirschprung''s Disease|NEC|Inflammatory Bowel Diseases|Meconium Ileus|Bowel Obstruction | McMaster University | September 1 2018 | Not Applicable |
| NCT03581149 | Recruiting | Ulcerative Colitis | American University of Beirut Medical Center | March 26 2018 | Phase 4 |
| NCT03581149 | Recruiting | Ulcerative Colitis | American University of Beirut Medical Center | March 26 2018 | Phase 4 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.
