Home Cell Cycle Rho inhibitor SAR407899 hydrochloride For research use only.

SAR407899 hydrochloride

SAR407899 hydrochloride is a selective, potent and ATP-competitive Rho kinase (ROCK) inhibitor, with an IC50 of 135 nM for ROCK-2, and Ki values of 36 and 41 nM for human and rat ROCK-2, respectively.

SAR407899 hydrochloride Chemical Structure

SAR407899 hydrochloride Chemical Structure

CAS: 923262-96-8

Purity & Quality Control

Batch: E238501 Water] 56 mg/mL] false] DMSO] 28 mg/mL] false] Ethanol] 1 mg/mL] false Purity: 98.7%
98.7

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Biological Activity

Description SAR407899 hydrochloride is a selective, potent and ATP-competitive Rho kinase (ROCK) inhibitor, with an IC50 of 135 nM for ROCK-2, and Ki values of 36 and 41 nM for human and rat ROCK-2, respectively.
Targets
human ROCK-2 [1]
(in assay of ROCK enzymatic activity)		 rat ROCK-2 [1]
(in assay of ROCK enzymatic activity)		 ROCK-2 [1]
(in selectivity assays)
36 nM(Ki) 41 nM(Ki) 135 nM(Ki)

Chemical Information & Solubility

Molecular Weight 280.75 Formula

C14H16N2O2.ClH
CAS No. 923262-96-8 SDF --
Smiles Cl.O=C1NC=CC2=C1C=CC(=C2)OC3CCNCC3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 56 mg/mL

DMSO : 28 mg/mL ( (99.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 1 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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