Home MAPK p38 MAPK inhibitor SB 242235 For research use only.

SB 242235

SB-242235 is a potent and selective p38 MAP kinase inhibitor, inhibits p38 MAP kinase induced by IL-1β with an IC50 of approximately 1.0 μM in primary human chondrocytes.

SB 242235 Chemical Structure

SB 242235 Chemical Structure

CAS: 193746-75-7

Purity & Quality Control

Batch: S038701 DMSO] 71 mg/mL] false] Ethanol] 71 mg/mL] false] Water] Insoluble] false Purity: 99.56%
99.56

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Biological Activity

Description SB-242235 is a potent and selective p38 MAP kinase inhibitor, inhibits p38 MAP kinase induced by IL-1β with an IC50 of approximately 1.0 μM in primary human chondrocytes.
Targets
p38 MAPK [1]
(in immune complex kinase assays)
1.0 μM

Chemical Information & Solubility

Molecular Weight 353.39 Formula

C19H20FN5O
CAS No. 193746-75-7 SDF --
Smiles COC1=NC=CC(=N1)C2=C(N=CN2C3CCNCC3)C4=CC=C(C=C4)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (200.91 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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