Succinic anhydride

Catalog No.S0586 Synonyms: SA, Succinyl Oxide, Succinyl Oxide

For research use only.

Succinic anhydride (SA, Succinyl Oxide, Butanedioic Anhydride) is a cyclic anhydride that can be used in the homogeneous chemical modification of cellulose and as a noncleavable ADC linker that reacts with other compound to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.

Succinic anhydride Chemical Structure

CAS No. 108-30-5

Purity & Quality Control

Choose Selective ADC Linker Inhibitors

Biological Activity

Description Succinic anhydride (SA, Succinyl Oxide, Butanedioic Anhydride) is a cyclic anhydride that can be used in the homogeneous chemical modification of cellulose and as a noncleavable ADC linker that reacts with other compound to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 100.07
Formula

C4H4O3

CAS No. 108-30-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC(=O)OC1=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03899597 Not yet recruiting Drug: Oxytocin|Other: Normal saline Neonatal Respiratory Distress Institute for the Care of Mother and Child Prague Czech Republic September 1 2022 Not Applicable
NCT04464603 Not yet recruiting Device: InterFACE (mHealth tool)|Other: Conventional methods Cardiopulmonary Arrest|Pediatric ALL|Resuscitation Pediatric Clinical Research Platform|University Hospital Geneva April 1 2022 Not Applicable
NCT04475393 Not yet recruiting Device: Carmat Total Artificial Heart Advanced Heart Failure Carmat SA March 2022 Not Applicable
NCT04672733 Suspended Biological: Hizentra Chronic Inflammatory Demyelinating Polyneuropathy CSL Behring March 2022 --
NCT04811833 Not yet recruiting -- Gastrointestinal Stromal Tumors|Gastrointestinal Neoplasms|Digestive System Neoplasm|Stomach Tumor|Small Intestine Tumor|Colon Tumor|Rectum Tumor Aesculap AG|B.Braun Surgical SA March 2022 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Succinic anhydride | Succinic anhydride supplier | purchase Succinic anhydride | Succinic anhydride cost | Succinic anhydride manufacturer | order Succinic anhydride | Succinic anhydride distributor