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SBI-115

Name: SBI-115
Brand: Selleck Chemicals
SKU: S6806
Rating: 5 (3 reviews)

Catalog No.S6806 Purity: 99.61%

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.

SBI-115 Chemical Structure

CAS: 882366-16-7

Selleck's SBI-115 has been cited by 3 publications

Purity & Quality Control

Batch: S680601 DMSO] 68 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.61%

99.61

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Biological Activity

Description

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.

Targets

TGR5 ^[1]

In vitro
In vitro	SBI-115, an inhibitor of TGR5, abolishes UDCA induced inhibition on cell growth (HCT116 cells, SW480 cells).^[1]
Cell Research	Cell lines	HCT116 cells, SW480 cells
	Concentrations	100μM
	Incubation Time	24 h
	Method	HCT116 and SW480 cells are pretreated with 100μM TGR5 antagonist SBI-115 for 24 h, and then treated with UDCA for 36 h. Cell proliferation is measured using MTT assays.

References

Chemical Information & Solubility

Molecular Weight	340.78	Formula	C₁₄H₁₃ClN₂O₄S
CAS No.	882366-16-7	SDF	--
Smiles	CCS(=O)(=O)C1=NC=C(C(=N1)C(=O)OC2=CC=CC(=C2)C)Cl
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 68 mg/mL ( (199.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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