Sulfathiazole

For research use only.

Catalog No.S3116

Sulfathiazole Chemical Structure

CAS No. 72-14-0

Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.

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10mM (1mL in DMSO) EUR 127 In stock
EUR 95 In stock
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Biological Activity

Description Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.
In vitro

Sulfathiazole (20 μg/L) starts to be degraded between day 31 and day 38 in one of the two batch reactors containing different wastewater matrices. Sulfathiazole is degraded at a substantially faster rate than sulfamethoxazole or sulfamethazine in the nitrification process (S3). [1] Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole has acidity constant of pKa of 7.1and retention times (tR) of 7.8. S/N values for Sulfathiazole are above 100 at the 1 mg/kg level. [2] Sulfathiazole sorption to inorganic sorbents exhibits pronounced pH dependence consistent with sorbate speciation and sorbent charge properties. Sulfathiazole cations are most important for sorption to clay minerals, followed by neutral species. [3] Sulfathiazole posseses at least five crystalline or polymorphic forms: I, II, III, IV and V. Although both amido and imido forms are possible for the sulfathiazole molecule, the Sulfathiazole exists in the solid state in the imido form. [4] Sulfathiazole (94.9 mg/L) causes a significant increase in reactive oxygen species (ROS) generation and lipid peroxidation in the presence of ultraviolet B (UV-B) light. Exposure to Sulfathiazole and UV-B light causes apparent up-regulation of alpha-esterase, hemoglobin, and vitellogenin mRNA and significantly affect the survival of daphnids. [5]

Protocol

Solubility (25°C)

In vitro DMSO 51 mg/mL (199.74 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 255.32
Formula

C9H9N3O2S2

CAS No. 72-14-0
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=CS2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID