SZL P1-41

For research use only.

Catalog No.S9724

SZL P1-41 Chemical Structure

CAS No. 222716-34-9

SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells.

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Biological Activity

Description SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells.
Targets
Skp2 [1]
()
In vitro

SZL P1-41 indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells.[1]

In vivo

SZL P1-41 also exhibits potent anti-tumor activity in animal studies.[1]

Protocol

Cell Research:

[1]

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  • Cell lines: PC3 cells
  • Concentrations: 10 μM, 20 μM
  • Incubation Time: 4 days
  • Method:

    For Skp2 inhibitor administration, 5~10 × 103 of cells are seeded in 12 wells in triplicate for 24 h and then treated with various doses of SZL P1-41 (refreshed every two days). After four days, cells are harvested, stained with 0.4% trypan blue solution, and viable cells are counted using hemocytometer under microscope by trypan-blue dye exclusion method. For doxorubicin treatment, 8× 103 of PC3 cells with were seeded in 12 wells in triplicate for 24 h and then treated with various doses of SZL P1-41 in the presence or absence of 10nM doxorubicin or 25 ng/ml cyclophosphamide for four and three days, respectively (refreshed every two days).


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: nude mice bearing A549 xenograft tumors, nude mice bearing PC3 xenograft tumors
  • Dosages: 80 mg/kg, 40 mg/kg
  • Administration: IP
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 5 mg/mL (11.89 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 420.52
Formula

C24H24N2O3S

CAS No. 222716-34-9
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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E3 Ligase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID