Molecular Weight(MW): 509.04
SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
Cited by 12 Publications
3 Customer Reviews
H3K27ac change. SMMC-7721 cells were treated with EPZ-6438 (1 μM) alone or in combination with histone acetyltransferase inhibitors C646 (5 μM) or SGC-CBP30 (5 μM) for 6 days. H3K27ac was examined by immunoblotting.
Cell, 2018, 175(1):186-199. SGC-CBP30 purchased from Selleck.
Combination of DDR1 and EP300 inhibitors synergistically alleviated BLM-induced pulmonary fibrosis and inflammation in vivo. Except for rats in the normal group, all rats were pre-treated with 2.5 U/Kg bleomycin at day 0, and were orally administrated CQ-061 (50 mg/kg) and/or SGC-CBP30 (25 mg/Kg) or normal saline (NS) once per day for 14 days (from days 1–14). At the 15th day of bleomycin injection, all rats were sacrificed, BALF were collected, and lung tissues were sectioned and subjected to H&E staining.
Biomed Pharmacother, 2018, 106:1727-1733. SGC-CBP30 purchased from Selleck.
Purity & Quality Control
Choose Selective Epigenetic Reader Domain Inhibitors
|Description||SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.|
|Features||CREBBP/EP300-selective chemical probe.|
As a CREBBP/EP300-selective chemical probe, SGC-CBP30 shows moderate cytotoxicity in U2OS cells and HeLa cells. 
|In vitro||DMSO||100 mg/mL (196.44 mM)|
|Ethanol||100 mg/mL (196.44 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
The recommend formulation of SGC-CBP30 (Cat S7256) for in vivo studies on your website is “2% DMSO+30% PEG 300+5% Tween 80+ddH2O”. Is this a suspension or clear solution?
S7256 SGC-CBP30 in 2% DMSO+30% PEG 300+5% Tween 80+ddH2O at 5mg/ml is a clear solution.