Sodium Monofluorophosphate
Catalog No.S4013 Synonyms: NSC248
Molecular Weight(MW): 143.95
Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.
Purity & Quality Control
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Biological Activity
| Description | Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM. | ||||||
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| Targets |
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| In vitro |
Monofluorophosphate (1 mM) induces a three-fold increase in proliferation rate of embryonic chick calvarial cells in serum-free monolayer cultures. 30 μM of Monofluorophosphate increases the activity of DNA and alkaline phosphatase in calvarial cells by 135% and 178%, respectively. In cultured intact calvaria, 30 μM of Monofluorophosphate increases DNA activity, alkaline phosphatase activity and collagen production by 143%, 186% and 151%, respectively. [2] |
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| In vivo | Monofluorophosphate displays potent activity on bone immobilization in vivo. Rats supplied with drinking water containing 50 ppm F as Monofluorophosphate show a significant increase in the bone sickness of mobile tibia and immobile tibia, compared with fluoride-free water group (1.48 vs 0.98 mm, 0.79 vs 0.40 mm, respectively). Monofluorophosphate does not change the specific gravities of the immobilized and non-immobilized tibiae of the rats. Administration of Monofluorophosphate increases the mineralization rate of bones and counteracts the decrease in bone thickness, ash content and specific gravity induced by immobilization, without changing the Ca/P ratio of the ash. [3] |
Protocol
Solubility (25°C)
| In vitro | Water | 29 mg/mL (201.45 mM) |
|---|---|---|
| DMSO | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 143.95 |
|---|---|
| Formula | FNa2O3P |
| CAS No. | 10163-15-2 |
| Storage | powder |
| in solvent | |
| Synonyms | NSC248 |
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Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02924350 | Completed | Dentin Sensitivity | GlaxoSmithKline | November 7 2016 | Not Applicable |
| NCT02768194 | Completed | Dentin Sensitivity | GlaxoSmithKline | July 6 2016 | Not Applicable |
| NCT02940821 | Completed | Dental Plaque|Gingivitis | Pearl Network | May 30 2016 | Not Applicable |
| NCT02371616 | Completed | Dentine Sensitivity | GlaxoSmithKline | September 29 2014 | Not Applicable |
| NCT02861664 | Completed | Dentin Sensitivity | GlaxoSmithKline | September 21 2016 | Not Applicable |
| NCT02740803 | Completed | Caries | University of Leeds | April 2016 | Not Applicable |
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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