Home Metabolism phosphatase inhibitor Sodium stibogluconate

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Sodium stibogluconate phosphatase inhibitor

Cat.No.S2435

Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). This compound inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. This chemical is a drug used in treatment of leishmaniasis.
Sodium stibogluconate phosphatase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 907.88

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Quality Control

Batch: Purity: 99.74%
99.74

Solubility

In vitro
Batch:

Water : 20 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 907.88 Formula

C12H35Na3O26Sb2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 16037-91-5 -- Storage of Stock Solutions

Synonyms SSG, Stibogluconate sodium, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001 Smiles O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].OCC(O)C1O[Sb]2(O)(OC1C(O2)C([O-])=O)O[Sb]34([O-])OC(C(O)CO)C(O3)C(O4)C([O-])=O

Mechanism of Action

Targets/IC50/Ki
SHP-1
SHP-2
PTP1B
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05957978 Recruiting
Primary Visceral Leishmaniasis
Drugs for Neglected Diseases|Novartis Pharmaceuticals
 April 3 2024 Phase 2
NCT02905435 Completed
Burns
PolyNovo Biomaterials Pty Ltd.|PPD|Department of Health and Human Services|Biomedical Advanced Research and Development Authority
 November 5 2016 Not Applicable

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