Sodium stibogluconate

Synonyms: SSG, Stibogluconate sodium, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001

Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.

Sodium stibogluconate Chemical Structure

Sodium stibogluconate Chemical Structure

CAS: 16037-91-5

Selleck's Sodium stibogluconate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.74%
99.74

Sodium stibogluconate Related Products

Choose Selective phosphatase Inhibitors

Biological Activity

Description Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.
Targets
SHP-1 [1] SHP-2 [1] PTP1B [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05957978 Not yet recruiting
Primary Visceral Leishmaniasis
Drugs for Neglected Diseases|Novartis Pharmaceuticals
January 31 2024 Phase 2
NCT02905435 Completed
Burns
PolyNovo Biomaterials Pty Ltd.|PPD|Department of Health and Human Services|Biomedical Advanced Research and Development Authority
November 5 2016 Not Applicable

Chemical Information & Solubility

Molecular Weight 907.88 Formula

C12H35Na3O26Sb2

CAS No. 16037-91-5 SDF --
Smiles O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].OCC(O)C1O[Sb]2(O)(OC1C(O2)C([O-])=O)O[Sb]34([O-])OC(C(O)CO)C(O3)C(O4)C([O-])=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 20 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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