Choose Your Country or Region

Saccharin 1-methylimidazole (SMI)

Name: Saccharin 1-methylimidazole (SMI)
Brand: Selleck Chemicals
SKU: S8326
Rating: 5 (1 reviews)

Catalog No.S8326 Purity: 99.03%

Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.

Saccharin 1-methylimidazole (SMI) Chemical Structure

CAS: 482333-74-4

Purity & Quality Control

Batch: S832601 DMSO] 53 mg/mL] false] Water] 53 mg/mL] false] Ethanol] 53 mg/mL] false Purity: 99.03%

99.03

Saccharin 1-methylimidazole (SMI) Related Products

Related Targets	tRNA synthetase RdRp DNA synthesis helicase ribonucleotide reductase	Click to Expand
Related Products	Gemcitabine 5-FU (5-Fluorouracil) Cytarabine Pidnarulex (CX-5461) Fludarabine Phosphate Hydroxyurea Sofosbuvir SCR7 Bendamustine HCl Cytarabine hydrochloride Favipiravir (T-705) m6A (N6-methyladenosine) RK-33 Lomustine Carmofur Triapine (3-AP) Mercaptopurine (6-MP) B02 BMH-21 YK-4-279 Floxuridine (FUDR) BrdU (Bromodeoxyuridine) Procarbazine HCl Bergapten Chloroambucil Tegafur (FT-207) Azaguanine-8 Halofuginone Adenine HCl Fidaxomicin Mupirocin Mizoribine Cyclocytidine HCl Thymidine Uridine APX-3330 Vidarabine Rifapentine Nedaplatin 6-Thio-dG Flupirtine maleate Carmustine JH-RE-06 Pritelivir (BAY 57-1293) TK216 Amenamevir Madrasin Tubercidin Rimantadine Hydrochloride BC-LI-0186 CRT0044876 PFM01 Adenine ML216 Rifaximin	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Apoptosis Compound Library DNA Damage/DNA Repair compound Library Cell Cycle compound library	Click to Expand

Signaling Pathway

DNA/RNA Synthesis Signaling Pathway

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description	Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06007794	Not yet recruiting	Cancer\|Post-cancer\|Hematology	Hospices Civils de Lyon	December 1 2023	Not Applicable
NCT06121492	Not yet recruiting	Sarcopenia\|Cirrhosis of the Liver	Mahidol University	November 15 2023	Phase 3
NCT05942495	Not yet recruiting	Depressive Symptoms\|Anxiety Disorders\|Persistent\|Anxiety Depression	GGZ Noord-Holland-Noord	November 2023	Not Applicable
NCT06102564	Not yet recruiting	Cluster C Personality Disorder (Diagnosis)\|Mother-Child Relations	Maastricht University\|Psychologiepraktijk Esra	November 2023	--

Chemical Information & Solubility

Molecular Weight	265.29	Formula	C₇H₅NO₃S.C₄H₆N₂
CAS No.	482333-74-4	SDF	Download Saccharin 1-methylimidazole (SMI) SDF
Smiles	CN1C=CN=C1.C1=CC=C2C(=C1)C(=O)NS2(=O)=O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 53 mg/mL ( (199.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 53 mg/mL

Ethanol : 53 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Tags: buy Saccharin 1-methylimidazole (SMI) | Saccharin 1-methylimidazole (SMI) supplier | purchase Saccharin 1-methylimidazole (SMI) | Saccharin 1-methylimidazole (SMI) cost | Saccharin 1-methylimidazole (SMI) manufacturer | order Saccharin 1-methylimidazole (SMI) | Saccharin 1-methylimidazole (SMI) distributor

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):