Saccharin 1-methylimidazole (SMI)

For research use only.

Catalog No.S8326

Saccharin 1-methylimidazole (SMI) Chemical Structure

Molecular Weight(MW): 265.29

Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.

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Biological Activity

Description Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.



Solubility (25°C)

In vitro DMSO 53 mg/mL (199.78 mM)
Water 53 mg/mL (199.78 mM)
Ethanol '53 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 265.29


CAS No. 482333-74-4
Storage powder
in solvent
Synonyms N/A
Smiles CN1C=CN=C1.C1=CC=C2C(=C1)C(=O)NS2(=O)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04444661 Active not recruiting -- Osteoporosis|Sarcopenia University of Erlangen-Nürnberg Medical School|Departement of Radiology Friedrich-Alexander University Erlangen-Nürnberg June 10 2020 --
NCT04175886 Recruiting Drug: Tofacitinib Rheumatoid Arthritis University Hospital Lille|Pfizer February 25 2020 --
NCT04011735 Completed Drug: Respimat Pulmonary Disease Chronic Obstructive Boehringer Ingelheim September 30 2019 --
NCT04037488 Not yet recruiting Diagnostic Test: Inbody 320 Sarcopenia|Prostate Cancer Seoul National University Hospital|HanAll BioPharma Co. Ltd. August 2019 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID