Home Neuronal Signaling Adrenergic Receptor agonist Synephrine HCl For research use only.

Synephrine HCl

SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.

Synephrine HCl Chemical Structure

Synephrine HCl Chemical Structure

CAS: 5985-28-4

Purity & Quality Control

Batch: S243801 Water] 41 mg/mL] false] DMSO] 14 mg/mL] false] Ethanol] 4 mg/mL] false Purity: 99.83%
99.83

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Signaling Pathway

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Biological Activity

Description SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
Targets
α-adrenergic receptor [1]
In vitro
In vitro Synephrine (0.1-30 μM) displays potent vasoconstrictive effects on isolated rat aorta in a dose dependent manner, which can be significantly inhibited by pretreatment with prazosin, BRL15572, and ketanserin but not by pretreatment with SB216641 and propranolol, indicating that Synephrine exerts the constrictive effects via adrenergic alpha(1)-receptors, serotonergic 5-HT(1D) receptors, and 5-HT(2A) receptors. [2] Although the Ki values of Synephrine, 1R,2S-norephedrine, and β-phenethylamine are same for all three subtypes, only Synephrine is a partial agonist of α1A-AR subtype stably expressed in HEK 293 cells with EC50 of 4 µM, giving a maximal response at 100 µM that is equal to 55.3 % of the L-phenylephrine maximum. Functional studies on the α2A- and α2C-AR subtypes stably expressed in CHO cells indicate that Synephrine may act as an antagonist rather than an agonist of the pre-synaptic α(2A)- and α(2C)-AR subtypes present in nerve terminals, although antagonist activity of synephrine is lower than its partial agonist potency. [3] Synephrine (~100 μM) treatment increases basal glucose consumption up to 50% over the control in a dose-dependent manner, without affecting the viability of L6 skeletal muscle cells. Synephrine significantly stimulates the basal- or insulin-stimulated lactic acid production as well as glucose consumption. Synephrine treatment stimulates the phosphorylation of AMPK but not Akt, and Synephrine-induced glucose consumption and the translocation of Glut4 from the cytoplasm to the plasma membrane are sensitive to the inhibition of AMPK but not to the inhibition of PI3 kinase. [4]
In Vivo
In vivo Administration of Synephrine (1 mg/kg per 12 hours) for 8 days significantly improves the hyperdynamic state in portal hypertensive rats induced by either partial portal vein ligation (PVL) or bile duct ligation (BDL), and significantly reduces the portal venous pressure, portal tributary blood flow and cardiac index in both PVL and BDL rats. [1]
Animal Research Animal Models Male Sprague-Dawley rats with portal hypertension (with or without cirrhosis) induced by bile duct ligation or partial portal vein ligation
Dosages ~1 mg/kg per 12 hours
Administration Oral gavage

Chemical Information & Solubility

Molecular Weight 203.67 Formula

C9H13NO2.HCl
CAS No. 5985-28-4 SDF Download Synephrine HCl SDF
Smiles CNCC(C1=CC=C(C=C1)O)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 41 mg/mL

DMSO : 14 mg/mL ( (68.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL


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In vivo
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