Name: SR-717 lithium
Brand: Selleck Chemicals
SKU: S0853
Rating: 5 (3 reviews)

SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.

SR-717 lithium Chemical Structure

CAS: 2375421-09-1

Selleck's SR-717 lithium has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.84%

99.84

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Biological Activity

Description

SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.

Targets

STING ^[1] (in ISG-THP1 (WT) cells)	STING ^[1] (in ISG-THP1 (cGAS KO) cells)
2.1 μM(EC50)	2.2 μM(EC50)

In vitro
In vitro	SR-717 induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner.^[1]
Cell Research	Cell lines	ISG-THP1 STING KO cell lines
	Concentrations	3.8 μM
	Incubation Time	4 h
	Method	"Western blot analyses the impact of SR-717 delivery (3.8 mM) on PD-L1 expression in WT THP1 or ISG-THP1 STING KO (STING KO) cells."

In Vivo
In vivo	SR-717 ( intraperitoneally for 7 days) displays antitumor activity in WT or Sting^gt/gt mice; promots the activation of CD8⁺ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming.

References

Chemical Information & Solubility

Molecular Weight	351.19	Formula	C₁₅H₈F₂LiN₅O₃
CAS No.	2375421-09-1	SDF	--
Smiles	[Li]OC(=O)C1=C(NC(=O)C2=NN=C(C=C2)[N]3C=CN=C3)C=C(F)C(=C1)F
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 20 mg/mL ( (56.94 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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