Home MAPK p38 MAPK inhibitor Skepinone-L For research use only.

Skepinone-L

Synonyms: CBS3830

Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.

Skepinone-L Chemical Structure

Skepinone-L Chemical Structure

CAS No. 1221485-83-1

Purity & Quality Control

Skepinone-L Related Products

Signaling Pathway

p38 MAPK Signaling Pathways

p38 MAPK Signaling Pathway

Biological Activity

Description Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.
Targets
p38α [1]
5 nM
In vitro
In vitro Skepinone-L shows concentration-dependent inhibition of HSP27 (Ser82) phosphorylation through the p38 MAPK pathway with a cellular IC50 of approximately 25 nM, and also reduces concentrations of TNF-α, IL-1β and IL-10, regulated by p38 MAPK, with IC50 ranging from 30 to 50 nM . [1] Skepinone-L (1 μM) abrogates the phosphorylation of platelet p38 MAPK substrate Hsp27 activated by stimulation with CRP, thrombin or thromboxane A2 analogue U-46619, and impairs platelet secretion and aggregation. [2]
In Vivo
In vivo In vivo, skepinone-L inhibits Gal/ LPS-induced TNF-α release by 77%. [1]
Animal Research Animal Models Mice
Dosages ~3 mg/kg
Administration Oral administration

Chemical Information & Solubility

Molecular Weight 425.42 Formula

C24H21F2NO4
CAS No. 1221485-83-1 SDF Download Skepinone-L SDF
Smiles C1CC2=C(C=CC(=C2)NC3=C(C=C(C=C3)F)F)C(=O)C4=C1C=CC(=C4)OCC(CO)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 85 mg/mL ( (199.8 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 85 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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