Home Metabolism ROR agonist SR3335

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SR3335 ROR agonist

Cat.No.S2969

SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
SR3335 ROR agonist Chemical Structure

Chemical Structure

Molecular Weight: 405.34

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Quality Control

Batch: S296901 DMSO]81 mg/mL]false]Ethanol]81 mg/mL]false]Water]Insoluble]false Purity: 99.83%
99.83

Chemical Information, Storage & Stability

Molecular Weight 405.34 Formula

C13H9F6NO3S2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 293753-05-6 -- Storage of Stock Solutions

Synonyms ML-176 Smiles OC(C1=CC=C(N[S](=O)(=O)C2=CC=CS2)C=C1)(C(F)(F)F)C(F)(F)F

Solubility

In vitro
Batch:

DMSO : 81 mg/mL ( (199.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 81 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
RORα [1]
(Cell-free assay)
220 nM(Ki)
In vitro

SR3335 (ML-176), a selective RORα synthetic ligand, directly binds to RORα, and functions as a selective partial inverse agonist of RORα, also suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.[1]
In vivo

SR3335 (ML-176) suppresses gluconeogenesis in diet-induced obesity (DIO) mouse model consistent with suppression of gluconeogenesis.[1]
References

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