Home GPCR & G Protein Endothelin Receptor antagonist - Angiotensin Receptor antagonist Sparsentan (PS-433540, RE-021) For research use only.

Sparsentan (PS-433540, RE-021)

Synonyms: DARA

Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.

Sparsentan (PS-433540, RE-021) Chemical Structure

Sparsentan (PS-433540, RE-021) Chemical Structure

CAS: 254740-64-2

Selleck's Sparsentan (PS-433540, RE-021) has been cited by 2 publications

Purity & Quality Control

Batch: S666501 DMSO] 100 mg/mL] false] Ethanol] 40 mg/mL] false] Water] Insoluble] false Purity: 99.71%
99.71

Sparsentan (PS-433540, RE-021) Related Products

Signaling Pathway

Endothelin Receptor Signaling Pathways

Endothelin Receptor Signaling Pathway

Choose Selective Endothelin Receptor Inhibitors

Biological Activity

Description Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
Targets
endothelin type A receptor [1] angiotensin II type 1 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05572229 Not yet recruiting
Multiple Myeloma
University Hospital Lille|Janssen Pharmaceutica N.V. Belgium
 September 2023 Phase 2
NCT05408026 Withdrawn
Relapsed or Refractory Multiple Myeloma
Alliance Foundation Trials LLC.|Janssen LP|Celgene
 October 1 2022 Phase 1|Phase 2
NCT05004259 Recruiting
Hemolytic Anemia
Dartmouth-Hitchcock Medical Center
 March 21 2022 Phase 1

Chemical Information & Solubility

Molecular Weight 592.75 Formula

C32H40N4O5S
CAS No. 254740-64-2 SDF --
Smiles CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (168.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Sparsentan (PS-433540, RE-021) | Sparsentan (PS-433540, RE-021) ic50 | Sparsentan (PS-433540, RE-021) price | Sparsentan (PS-433540, RE-021) cost | Sparsentan (PS-433540, RE-021) solubility dmso | Sparsentan (PS-433540, RE-021) purchase | Sparsentan (PS-433540, RE-021) manufacturer | Sparsentan (PS-433540, RE-021) research buy | Sparsentan (PS-433540, RE-021) order | Sparsentan (PS-433540, RE-021) mouse | Sparsentan (PS-433540, RE-021) chemical structure | Sparsentan (PS-433540, RE-021) mw | Sparsentan (PS-433540, RE-021) molecular weight | Sparsentan (PS-433540, RE-021) datasheet | Sparsentan (PS-433540, RE-021) supplier | Sparsentan (PS-433540, RE-021) in vitro | Sparsentan (PS-433540, RE-021) cell line | Sparsentan (PS-433540, RE-021) concentration | Sparsentan (PS-433540, RE-021) nmr