Serotonin HCl

Catalog No.S4244 Synonyms: 5-HT HCl

For research use only.

Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

Serotonin HCl Chemical Structure

CAS No. 153-98-0

Selleck's Serotonin HCl has been cited by 5 Publications

Purity & Quality Control

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Biological Activity

Description Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
5-HT [1]
In vitro

Serotonin stimulates acid–base transport by the anterior stomach region of the midgut in vitro. The function of this stimulation is assumed to be maintenance of optimal conditions for digestion and absorption of nutrients rather than regulation of hemolymph acid–base homeostasis. [1]

Methods Test Index PMID
Western blot FAS / L-FABP1 / pS79-ACC / ACC / SREBP1 / SCD1 / pPPARα / PPAR-γ ; LC3β / ATG3 / pS65-4EBP1 / Beclin-1 / SIRT1 / p62 / FOXO3a 30409162
Growth inhibition assay Cell proliferation 30409162
In vivo The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 42 mg/mL
(197.47 mM)
Water 42 mg/mL
(197.47 mM)
Ethanol 2 mg/mL
(9.4 mM)

Chemical Information

Molecular Weight 212.68


CAS No. 153-98-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC2=C(C=C1O)C(=CN2)CCN.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04754061 Not yet recruiting Drug: Psilocybin Depression Anxiety|Distress Emotional Ottawa Hospital Research Institute|Bruyere Research Institute|The Ottawa Hospital|St. Joseph''s Healthcare Hamilton|CHU de Quebec-Universite Laval|Centre de recherche du Centre hospitalier universitaire de Sherbrooke|Jewish General Hospital|William Osler Health System|Kingston Health Sciences Centre March 2022 Phase 1|Phase 2
NCT05151601 Not yet recruiting Dietary Supplement: Experimental|Other: Placebo Autism Spectrum Disorder|Neurodevelopmental Disorders|Anxiety The University of Queensland February 1 2022 Not Applicable
NCT04869930 Recruiting Other: specimen collection Autism Spectrum Disorder|Fra(X) Syndrome Nova Mentis Life Science Corp|FourthWall Testing November 1 2021 --

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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