Serotonin HCl

Catalog No.S4244 Synonyms: 5-HT HCl

Serotonin HCl Chemical Structure

Molecular Weight(MW): 212.68

Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

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Biological Activity

Description Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
5-HT [1]
In vitro

Serotonin stimulates acid–base transport by the anterior stomach region of the midgut in vitro. The function of this stimulation is assumed to be maintenance of optimal conditions for digestion and absorption of nutrients rather than regulation of hemolymph acid–base homeostasis. [1]

In vivo The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. [1]


Solubility (25°C)

In vitro DMSO 42 mg/mL (197.47 mM)
Water 42 mg/mL (197.47 mM)
Ethanol 2 mg/mL (9.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 212.68


CAS No. 153-98-0
Storage powder
in solvent
Synonyms 5-HT HCl

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03576053 Recruiting Itch|Thermal Stimulation|Histamine|Cowhage|Serotonine Aalborg University July 1 2018 Not Applicable
NCT03471819 Not yet recruiting Dermatologic Disease Assiut University April 1 2018 --
NCT03222570 Recruiting Depressive Disorder University of Minnesota - Clinical and Translational Science Institute February 26 2018 Phase 2
NCT03321526 Active not recruiting Depressive Disorder Major Janssen Research & Development LLC December 12 2017 Phase 2
NCT03364075 Terminated Low Back Pain Mark Ware|McGill University Health Center September 1 2017 Phase 2
NCT02865642 Recruiting Stroke University Hospital Inselspital Berne|Cantonal Hospital of St. Gallen August 2016 Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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5-HT Receptor Signaling Pathway Map

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