Serotonin HCl

For research use only.

Catalog No.S4244 Synonyms: 5-HT HCl

1 publication

Serotonin HCl Chemical Structure

CAS No. 153-98-0

Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

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Selleck's Serotonin HCl has been cited by 1 publication

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Biological Activity

Description Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
Targets
5-HT [1]
In vitro

Serotonin stimulates acid–base transport by the anterior stomach region of the midgut in vitro. The function of this stimulation is assumed to be maintenance of optimal conditions for digestion and absorption of nutrients rather than regulation of hemolymph acid–base homeostasis. [1]

Assay
Methods Test Index PMID
Western blot
FAS / L-FABP1 / pS79-ACC / ACC / SREBP1 / SCD1 / pPPARα / PPAR-γ; 

PubMed: 30409162     


HepG2 and SK-Hep1 cells were treated with indicated concentrations of serotonin for 24 h and 50 μg cell lysates were immunoblotted with indicated lipid metabolic proteins antibodies.

LC3β / ATG3 / pS65-4EBP1 / Beclin-1 / SIRT1 / p62 / FOXO3a; 

PubMed: 30409162     


HepG2 and SK-Hep1 cells were treated with indicated concentrations of serotonin for 24 h. Cells were lysed and 50 μg proteins were immunoblotted with indicated antibodies.

30409162
Growth inhibition assay
Cell proliferation; 

PubMed: 30409162     


Upper Panel: HepG2 and SK-Hep1 cells were grown in 96 well plates and treated with indicated concentrations (0.1–0.5 mM) of serotonin for 48 h and cell proliferation was measured using WST1 assay as described in the materials and methods section. Lower Panel: HepG2 and SK-Hep1 cells were grown in 96 well plates treated with indicated concentrations of serotonin for 48 h. Cell survival was measured using MTT assay on Fluostar Omega plate reader as described in materials and methods section.

30409162
In vivo The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. [1]

Protocol

Solubility (25°C)

In vitro DMSO 42 mg/mL (197.47 mM)
Water 42 mg/mL (197.47 mM)
Ethanol 2 mg/mL (9.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 212.68
Formula

C10H12N2O.HCl

CAS No. 153-98-0
Storage powder
in solvent
Synonyms 5-HT HCl
Smiles C1=CC2=C(C=C1O)C(=CN2)CCN.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04672226 Not yet recruiting Dietary Supplement: PDE MAX Pyridoxine Dependant Epilepsy Vitaflo International Ltd|Radboud UMC|Great Ormond Street Hospital for Children NHS Foundation Trust January 15 2021 Not Applicable
NCT04518072 Not yet recruiting Other: Blood sample (2 EDTA tube) and urine sample (100 ml) Prostate|Cancer University Hospital Montpellier|MICALIS|CBS November 15 2020 --
NCT04546698 Recruiting Other: blood sampling Multiple Sclerosis Acute Relapsing|Multiple Sclerosis Centre Hospitalier Régional d''Orléans|National Scientific Research Centre September 7 2020 --
NCT04676139 Recruiting Drug: Fluoxetine|Drug: Placebo Nocturnal Enuresis Mansoura University July 1 2020 Phase 3
NCT04365166 Recruiting -- Respiratory Tract Infections|Respiratory Tract Disease Direction Centrale du Service de Santé des Armées April 21 2020 --

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID