Serotonin HCl

Catalog No.S4244 Synonyms: 5-HT HCl

Serotonin HCl Chemical Structure

Molecular Weight(MW): 212.68

Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

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Biological Activity

Description Serotonin HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
5-HT [1]
In vitro

Serotonin stimulates acid–base transport by the anterior stomach region of the midgut in vitro. The function of this stimulation is assumed to be maintenance of optimal conditions for digestion and absorption of nutrients rather than regulation of hemolymph acid–base homeostasis. [1]

In vivo The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. [1]


Solubility (25°C)

In vitro DMSO 42 mg/mL (197.47 mM)
Water 42 mg/mL (197.47 mM)
Ethanol 2 mg/mL (9.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 212.68


CAS No. 153-98-0
Storage powder
in solvent
Synonyms 5-HT HCl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03996356 Not yet recruiting Other: No study intervention - observational study Weight Gain|Antipsychotic Agents|Pharmacogenetics Cwm Taf University Health Board (NHS) March 2020 --
NCT03994965 Not yet recruiting Drug: Pimavanserin 34 milligrams (MG) [Nuplazid] Schizophrenia|Psychosis Bjorn H. Ebdrup|Rigshospitalet Denmark|GCP unit Copenhagen University Hospital|ACADIA Pharmaceuticals Inc.|University of Copenhagen January 2020 Phase 2
NCT03924154 Recruiting Drug: RVT-1201|Drug: Placebo Pulmonary Arterial Hypertension Altavant Sciences GmbH|Altavant Sciences Inc.|PPD August 1 2019 Phase 2
NCT03788759 Recruiting Drug: Alpha-lipoic acid|Drug: Placebo Oral Tablet Schizophrenia|Oxidative Stress Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara|Conselho Nacional de Desenvolvimento Científico e Tecnológico June 2019 Phase 2|Phase 3

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5-HT Receptor Signaling Pathway Map

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