SCH-23390 hydrochloride

Catalog No.S0476 Synonyms: R-(+)-SCH-23390 hydrochloride, SCH-23390 HCl

For research use only.

SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.

SCH-23390 hydrochloride Chemical Structure

CAS No. 125941-87-9

Purity & Quality Control

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Biological Activity

Description SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
Targets
D1 dopamine receptor [1]
(Cell-free assay)
D5 dopamine receptor [1]
(Cell-free assay)
h5-HT2C receptor [2]
(Cell-free assay)
GIRK [3]
(Cell-free assay)
0.2 nM(Ki) 0.3 nM(Ki) 9.3 nM(Ki) 268 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 65 mg/mL
(200.46 mM)
Water 20 mg/mL
(61.68 mM)
Ethanol '25 mg/mL

Chemical Information

Molecular Weight 324.24
Formula

C17H19Cl2NO

CAS No. 125941-87-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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