SCH-23390 hydrochloride

For research use only.

Catalog No.S0476 Synonyms: R-(+)-SCH-23390 hydrochloride, SCH-23390 HCl

SCH-23390 hydrochloride Chemical Structure

CAS No. 125941-87-9

SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.

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Biological Activity

Description SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
Targets
D1 dopamine receptor [1]
(Cell-free assay)
D5 dopamine receptor [1]
(Cell-free assay)
h5-HT2C receptor [2]
(Cell-free assay)
GIRK [3]
(Cell-free assay)
0.2 nM(Ki) 0.3 nM(Ki) 9.3 nM(Ki) 268 nM

Protocol

Solubility (25°C)

In vitro DMSO 65 mg/mL (200.46 mM)
Water 20 mg/mL (61.68 mM)
Ethanol '25 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 324.24
Formula

C17H19Cl2NO

CAS No. 125941-87-9
Storage powder
in solvent
Synonyms R-(+)-SCH-23390 hydrochloride, SCH-23390 HCl
Smiles CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl.Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID