Home Neuronal Signaling Dopamine Receptor antagonist - 5-HT Receptor agonist - Potassium Channel inhibitor SCH-23390 hydrochloride For research use only.

SCH-23390 hydrochloride

Synonyms: R-(+)-SCH-23390 hydrochloride, SCH-23390 HCl

SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.

SCH-23390 hydrochloride Chemical Structure

SCH-23390 hydrochloride Chemical Structure

CAS: 125941-87-9

Selleck's SCH-23390 hydrochloride has been cited by 2 publications

Purity & Quality Control

Batch: S047601 DMSO] 65 mg/mL] false] Ethanol] 25 mg/mL] false] Water] 20 mg/mL] false Purity: 99.92%
99.92

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Signaling Pathway

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Biological Activity

Description SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. SCH-23390 hydrochloride is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. SCH-23390 hydrochloride directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.
Targets
D1 dopamine receptor [1]
(Cell-free assay)		 D5 dopamine receptor [1]
(Cell-free assay)		 h5-HT2C receptor [2]
(Cell-free assay)		 GIRK [3]
(Cell-free assay)
0.2 nM(Ki) 0.3 nM(Ki) 9.3 nM(Ki) 268 nM

Chemical Information & Solubility

Molecular Weight 324.24 Formula

C17H19Cl2NO
CAS No. 125941-87-9 SDF --
Smiles CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 65 mg/mL ( (200.46 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : 20 mg/mL


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