Home GPCR & G Protein Glucagon Receptor agonist Semaglutide Sodium

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Semaglutide Sodium Glucagon Receptor agonist

Cat.No.E7333

Semaglutide Sodium (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM).
Semaglutide Sodium Glucagon Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 4113.58(free base)

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Quality Control

Batch: E733301 Water]100 mg/mL]false]DMSO]16 mg/mL]false]Ethanol]Insoluble]false Purity: 99.74%
99.74

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : 16 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 4113.58(free base) Formula

C187H291N45O59

 Storage (From the date of receipt)
CAS No. 910463-68-2(free base) -- Storage of Stock Solutions

Mechanism of Action

In vitro

Semaglutide is selected as the optimal once weekly candidate. Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of semaglutide (0.38 ± 0.06 nM) is three-fold decreased compared to liraglutide, whereas the albumin affinity is increased.
In vivo

The plasma half-life is 46.1 h in mini-pigs following i.v. administration, and semaglutide has an MRT of 63.6 h after s.c. dosing to mini-pigs.
References

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