Home Neuronal Signaling NMDAR agonist - GlyT inhibitor - Amino acid transporter inhibitor Sarcosine For research use only.

Sarcosine

Synonyms: N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine

Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

Sarcosine Chemical Structure

Sarcosine Chemical Structure

CAS: 107-97-1

Purity & Quality Control

Batch: S470201 Water] 17 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.36%
99.36

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Biological Activity

Description Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
Targets
GlyT1 [1] N-methyl-D-aspartate receptor [1] GlyR [1]
In vitro
In vitro Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4].
Cell Research Cell lines PC-3 prostate cancer cell line
Concentrations 10, 150, 250, 500, 1,000 and 1,500 μM
Incubation Time 0, 6, 12, 24 and 72 h
Method Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.
In Vivo
In vivo Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3].
Animal Research Animal Models Male Albino Swiss mice
Dosages 100,200,400 and 800 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05319262 Completed
Noise Exposure|Sleep Disturbance|Sleep Hygiene|Metabolic Disturbance|Cognitive Change
Göteborg University|University of Pennsylvania|University of Manitoba
 April 24 2022 Not Applicable
NCT04949607 Completed
Brain Injury Chronic|Brain Injuries Traumatic
Centre for Neuro Skills|University of Texas
 July 28 2021 Not Applicable
NCT02404337 Completed
Homocystinuria
Assistance Publique - Hôpitaux de Paris
 July 2015 Phase 2
NCT02462447 Completed
Prostate Cancer
University of Michigan|National Institutes of Health (NIH)|National Cancer Institute (NCI)
 June 2015 --
NCT01503359 Completed
Schizophrenia
Medical University of Lodz
 January 2012 Phase 2

Chemical Information & Solubility

Molecular Weight 89.09 Formula

C3H7NO2
CAS No. 107-97-1 SDF Download Sarcosine SDF
Smiles CNCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 17 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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