Home Neuronal Signaling NMDAR agonist Sarcosine

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Sarcosine NMDAR agonist

Cat.No.S4702

Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
Sarcosine NMDAR agonist Chemical Structure

Chemical Structure

Molecular Weight: 89.09

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Batch: S470201 Water]17 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.36%
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99.36

Solubility

In vitro
Batch:

Water : 17 mg/mL

DMSO : Insoluble
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Ethanol : Insoluble

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Chemical Information, Storage & Stability

Molecular Weight 89.09 Formula

C3H7NO2

 Storage (From the date of receipt)
CAS No. 107-97-1 Download SDF Storage of Stock Solutions

Synonyms N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine Smiles CNCC(=O)O

Mechanism of Action

Targets/IC50/Ki
GlyT1
N-methyl-D-aspartate receptor
GlyR
In vitro
Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist. The viability of the sarcosine-treated cells is significantly reduced.
In vivo
Sarcosine has weak anticonvulsant properties. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05319262 Completed
Noise Exposure|Sleep Disturbance|Sleep Hygiene|Metabolic Disturbance|Cognitive Change
Göteborg University|University of Pennsylvania|University of Manitoba
 April 24 2022 Not Applicable
NCT04949607 Completed
Brain Injury Chronic|Brain Injuries Traumatic
Centre for Neuro Skills|University of Texas
 July 28 2021 Not Applicable
NCT02404337 Completed
Homocystinuria
Assistance Publique - Hôpitaux de Paris
 July 2015 Phase 2
NCT02462447 Completed
Prostate Cancer
University of Michigan|National Institutes of Health (NIH)|National Cancer Institute (NCI)
 June 2015 --

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