Catalog No.S4702 Synonyms: N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine
Molecular Weight(MW): 89.09
Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
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|Description||Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.|
Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist. The viability of the sarcosine-treated cells is significantly reduced.
|In vivo||Sarcosine has weak anticonvulsant properties. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice.|
|In vitro||Water||17 mg/mL (190.81 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine|
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