Sacubitril hemicalcium salt

For research use only.

Catalog No.S4426 Synonyms: AHU-377 hemicalcium salt

Sacubitril hemicalcium salt Chemical Structure

CAS No. 1369773-39-6

Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).

Purity & Quality Control

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Biological Activity

Description Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).
Targets
NEP [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (116.13 mM)
Water Insoluble
Ethanol '100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 861.04
Formula

C48H56CaN2O10

CAS No. 1369773-39-6
Storage powder
in solvent
Synonyms AHU-377 hemicalcium salt

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04735354 Active not recruiting Drug: sacubitril/valsartan Heart Failure Novartis Pharmaceuticals|Novartis October 27 2020 --
NCT04753112 Recruiting Drug: Sacubitril / Valsartan Oral Tablet [Entresto] Pulmonary Hypertension Germans Trias i Pujol Hospital October 29 2020 Phase 3
NCT04128891 Withdrawn Drug: Sacubitril-Valsartan Heart Failure With Preserved Ejection Fraction Flinders University February 1 2020 Phase 3
NCT04206501 Recruiting Device: Medtronic ICD with Opti Vol-Monitor Ischemic and Non-ischemic Cardiomyopathy University of Rochester|Medtronic February 5 2020 Not Applicable
NCT04133428 Recruiting Drug: Sacubitril-Valsartan Heart Failure Fundación Pública Andaluza para la gestión de la Investigación en Sevilla April 4 2019 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID