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Sacituzumab-govitecan ADC Cytotoxin chemical

Cat.No.E2841

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4002.
Sacituzumab-govitecan ADC Cytotoxin chemical Chemical Structure

Chemical Structure

Molecular Weight: 160000

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Quality Control

Batch: E284101 Purity: 98.93%
98.93

Solubility

In vitro
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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 160000 Formulation 10mg/mL in PBS DAR 7.6
Antibody Sacituzumab ADC Cytotoxin SN-38 Formula C76H104N12O24S
CAS No. 1491917-83-9 (ADC) Storage (From the date of receipt) 1 year -80°C in solvent Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Mechanism of Action

In vitro

Sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) made from a humanized anti-Trop-2 monoclonal antibody (hRS7) conjugated with the active metabolite of irinotecan, SN-38, shows anticancer activity in cancers expressing Trop-2, including gastric and pancreatic cancer.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06161532 Not yet recruiting
Small Cell Carcinoma of the Bladder|Small Cell Carcinoma of the Urinary Tract|Squamous Cell Carcinoma of the Bladder|Squamous Cell Carcinoma of the Urinary Tract|Primary Adenocarcinoma of the Bladder|Primary Adenocarcinoma of the Urinary Tract|Renal Medullary Carcinoma|Squamous Cell Carcinoma of the Penis
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 May 15 2024 Phase 2
NCT06236269 Not yet recruiting
Breast Cancer Stage IV
SOLTI Breast Cancer Research Group
 February 20 2024 Phase 2
NCT06028932 Recruiting
Ovarian Carcinoma
Yale University|Gilead Sciences
 January 8 2024 Phase 2
NCT06167317 Recruiting
Advanced Solid Tumors
Gilead Sciences
 January 9 2024 Phase 1
NCT05838521 Recruiting
Cervical Cancer
Yale University|Gilead Sciences
 June 2 2023 Phase 2

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Frequently Asked Questions

Question 1:
What's the solvent of this ADC drug? And what's its concentration?

Answer:
The solvent is a PBS solution. Its concentration is 10mg/ml.

Question 2:
What is its molecular weight?

Answer:
It contains on average 7 to 8 molecules of SN-38 per antibody molecule. This compound has a molecular weight of approximately 160 kilodaltons. The molecular weight of the drug (SN-38) and linker other than the antibody is 1601.8.