Super-TDU

Catalog No.S8554

Super-TDU Chemical Structure

Molecular Weight(MW): 5279.94

Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.

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Choose Selective Hippo pathway Inhibitors

Biological Activity

Description Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
Targets
YAP/TEAD interaction [1]
()
In vitro

Super-TDU reduced endogenous interaction between YAP and TEADs. It inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27, but not MKN-45. Moreover, the Super-TDU downregulated expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU significantly inhibited growth of HeLa, MGC-803, HCT116, A549, and MCF-7 cells, but only marginally inhibited growth of Jurkat and Raji cells, indicating a selectivity of the Super-TDU in inhibiting tumor cell growth. Super-TDU may specifically target tumor cells with an elevated YAP/VGLL4 ratio[1].

In vivo Super-TDU has the potential in treating gastric cancer by directly targeting YAP-TEADs, and importantly, unlike the conventional drug compound 5-FU, its antitumor activity tends to be specific toward tumors with an elevated ratio of YAP to VGLL4[1].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: HCT116 and SW480 cells
  • Concentrations: 0-320 ng/ml
  • Incubation Time: 72 h
  • Method:

    Cells are transfected with the indicated plasmids. An ATP-based cell viability assay is used for detecting cell proliferation. The ATP content is measured. Briefly, 100 μl of assay reagent is added to the wells, and mixed for 2 min at room temperature. After 10 min, intracellular ATP content is measured using a multilabel luminescence counter. Cell viability is calculated.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: BALB/cA nu/nu mice
  • Formulation: saline
  • Dosages: 50 or 500 μg/kg
  • Administration: tail vein injection
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (18.93 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 5279.94
Formula

C237H370N66O69S

CAS No. 1599441-71-0
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID