Catalog No.S8554

For research use only.

Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.

Super-TDU Chemical Structure

CAS No. 1599441-71-0

Selleck's Super-TDU has been cited by 4 Publications

Purity & Quality Control

Choose Selective YAP Inhibitors

Biological Activity

Description Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
YAP/TEAD interaction [1]
In vitro

Super-TDU reduced endogenous interaction between YAP and TEADs. It inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27, but not MKN-45. Moreover, the Super-TDU downregulated expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU significantly inhibited growth of HeLa, MGC-803, HCT116, A549, and MCF-7 cells, but only marginally inhibited growth of Jurkat and Raji cells, indicating a selectivity of the Super-TDU in inhibiting tumor cell growth. Super-TDU may specifically target tumor cells with an elevated YAP/VGLL4 ratio[1].

In vivo Super-TDU has the potential in treating gastric cancer by directly targeting YAP-TEADs, and importantly, unlike the conventional drug compound 5-FU, its antitumor activity tends to be specific toward tumors with an elevated ratio of YAP to VGLL4[1].

Protocol (from reference)

Cell Research:


  • Cell lines: HCT116 and SW480 cells
  • Concentrations: 0-320 ng/ml
  • Incubation Time: 72 h
  • Method:

    Cells are transfected with the indicated plasmids. An ATP-based cell viability assay is used for detecting cell proliferation. The ATP content is measured. Briefly, 100 μl of assay reagent is added to the wells, and mixed for 2 min at room temperature. After 10 min, intracellular ATP content is measured using a multilabel luminescence counter. Cell viability is calculated.

Animal Research:


  • Animal Models: BALB/cA nu/nu mice
  • Dosages: 50 or 500 μg/kg
  • Administration: tail vein injection

Solubility (25°C)

In vitro

Water 100 mg/mL
(18.93 mM)
Ethanol '-1 mg/mL

Chemical Information

Molecular Weight 5279.94


CAS No. 1599441-71-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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