For research use only.

Catalog No.S8554

3 publications

Super-TDU Chemical Structure

CAS No. 1599441-71-0

Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.

Selleck's Super-TDU has been cited by 3 publications

Purity & Quality Control

Choose Selective YAP Inhibitors

Biological Activity

Description Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
YAP/TEAD interaction [1]
In vitro

Super-TDU reduced endogenous interaction between YAP and TEADs. It inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27, but not MKN-45. Moreover, the Super-TDU downregulated expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU significantly inhibited growth of HeLa, MGC-803, HCT116, A549, and MCF-7 cells, but only marginally inhibited growth of Jurkat and Raji cells, indicating a selectivity of the Super-TDU in inhibiting tumor cell growth. Super-TDU may specifically target tumor cells with an elevated YAP/VGLL4 ratio[1].

In vivo Super-TDU has the potential in treating gastric cancer by directly targeting YAP-TEADs, and importantly, unlike the conventional drug compound 5-FU, its antitumor activity tends to be specific toward tumors with an elevated ratio of YAP to VGLL4[1].


Cell Research:


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  • Cell lines: HCT116 and SW480 cells
  • Concentrations: 0-320 ng/ml
  • Incubation Time: 72 h
  • Method:

    Cells are transfected with the indicated plasmids. An ATP-based cell viability assay is used for detecting cell proliferation. The ATP content is measured. Briefly, 100 μl of assay reagent is added to the wells, and mixed for 2 min at room temperature. After 10 min, intracellular ATP content is measured using a multilabel luminescence counter. Cell viability is calculated.

    (Only for Reference)
Animal Research:


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  • Animal Models: BALB/cA nu/nu mice
  • Dosages: 50 or 500 μg/kg
  • Administration: tail vein injection
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (18.93 mM)
Ethanol '-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 5279.94


CAS No. 1599441-71-0
Storage powder
in solvent
Synonyms N/A
Smiles CCC(C)C(C(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(CC(=O)N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)C(=O)C(CCC(=O)N)NNC(C(C)O)C(=O)NC(C(C)C)C(=O)N3CCCC3C(=O)NC(CCSC)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=䲧瘆Ỵ瘇㧀瘅膉疴睥ଐ঵ី'঵ð㺣疲帉疲Ѐ瑖猗﫜돸ቬ঵ð鄸ቬ彿猘奋猘巫猘쟜ቬ쫀ቬ彿猘쪴ቬ塚猘쫀ቬꍈ猝돸ቬ學猘漸猝圔猘돸ቬ圞猘圭猘﫜玚Wី' ី'戤睕$๰ઇ䐺疲暼睥๰ઇី' ๰ઇð㺣疲๰ઇ€﫜๴ઇ€䀷疳๴ઇا๴ઇ㵶疳๴ઇ됬ቬ若Item쭄ቬCount﫴歷຤ઇ쫄੟๴ઇ੟씢疳쫈੟㸶䥷猘쟜ቬ쭄ቬ�猝쪴ቬ੟籠﫜猙՚﫤礤v�猝쪴ቬ猢W쭄ቬ䨼Ą樓﫤良獸W列𢡄玛W列怠ٙ﫤礤v玚W玢W怠ٙ﫼礌vtЉ�ނ鲬ا᥊瘅쨘੟Eo쩬੟ﬠ੤ﬠ੤단˚䥠˘씢疳쩰੟댬ቬi頻ﱤ﫼﬜먙猗댬ቬ쩰੟i

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID