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Sofpironium bromide

Name: Sofpironium bromide
Brand: Selleck Chemicals
SKU: E2874
Rating: 5 (1 reviews)

Synonyms: BBI 4000

Catalog No.E2874 Purity: 99.72%

Sofpironium bromide (BBI 4000) is an anticholinergic agent that reduces sweat by inhibiting M3 muscarinic receptors in eccrine glands.

Sofpironium bromide Chemical Structure

CAS: 1628106-94-4

Purity & Quality Control

Batch: E287401 DMSO] 94 mg/mL] false] Water] 94 mg/mL] false] Ethanol] 94 mg/mL] false Purity: 99.72%

99.72

Sofpironium bromide Related Products

Related Targets	mAChR nAChR AChE	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-alzheimer Disease Compound Library	Click to Expand

Signaling Pathway

AChR Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description

Sofpironium bromide (BBI 4000) is an anticholinergic agent that reduces sweat by inhibiting M3 muscarinic receptors in eccrine glands.

Targets

mAChR ^[1]

References

[1] Paik J, et al.Drugs. 2020 Dec;80(18):1981-1986.

Chemical Information & Solubility

Molecular Weight	470.40	Formula	C₂₂H₃₂NO₅.Br
CAS No.	1628106-94-4	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 94 mg/mL ( (199.82 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 94 mg/mL

Ethanol : 94 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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