Sevelamer HCl

For research use only.

Catalog No.S4129

Sevelamer HCl Chemical Structure

CAS No. 152751-57-0

Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

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Biological Activity

Description Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
In vivo Sevelamer is as effective as CaCO3 in reducing serum phosphorus, calcium-phosphorus product, and attenuating secondary hyperparathyroidism in nephrectomized rats (U) fed high phosphorus (HP) diet. Sevelamer results in markedly lower calcium deposition in the myocardium and aorta compared to control rats. [1] Sevelamer suppresses calcification of the aorta media, and also the osteoid volume, fibrosis volume, and porosity ratio of femurs in chronic renal failure rats. [2] Sevelamer results in a significantly lower degree of atherosclerosis and vascular calcification in uremic mice when compared with uremic control mice. Sevelamer exerts an effect on both intima and media calcification in uremic mice. [3] Sevelamer treatment controlled serum P independent of increases in serum Ca, thus reducing serum calcium-phosphate product and further deterioration of renal function, as indicated by the highest creatinine clearances in uremic rats. Sevelamer is as effective as CaCO3 in the control of high-P-induced SH, as shown by similar serum PTH levels, parathyroid (PT) gland weight, and markers of PT hyperplasia. Sevelamer causes a dramatic reduction of renal Ca deposition compared with both uremic + high-P diet (U-HP) and the U-HP+CaCO3 diet. [4] Sevelamer hydrochloride results in a fall in urine pH, as well as an increase in urinary ammonium and calcium excretion consistent with an increase in net acid excretion in animal model. [5]

Protocol

Solubility (25°C)

In vitro DMSO 0.005 mg/mL
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight
Formula

(C3H7N.C3H5ClO.HCl)x

CAS No. 152751-57-0
Storage powder
in solvent
Synonyms N/A
Smiles C=CCN.C1C(O1)CCl.Cl

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01220843 Completed Drug: Placebo|Drug: Sevelamer carbonate Chronic Renal Failure Centre Hospitalier Universitaire Amiens|Genzyme a Sanofi Company October 2010 Phase 3
NCT01191762 Completed Drug: sevelamer carbonate|Drug: placebo Hyperparathyroidism|Chronic Kidney Disease Kenneth R. Phelps M.D.|Genzyme a Sanofi Company|Phelps Kenneth R. M.D. April 2010 Phase 3
NCT01011699 Terminated Drug: nicotinamide|Drug: sevelamer|Drug: cinacalcet Chronic Renal Failure|Hemodialysis Centre Hospitalier Universitaire Amiens January 2010 Phase 3
NCT00853242 Completed Drug: Placebo|Drug: Genz-644470|Drug: Sevelamer carbonate Kidney Failure Chronic Genzyme a Sanofi Company|Sanofi February 2009 Phase 2

Tech Support

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