SN-38

Catalog No.S4908

SN-38 Chemical Structure

Molecular Weight(MW): 392.4

SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

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Cited by 13 Publications

5 Customer Reviews

  • HCT116 cells were pretreated with tested compounds for 1 hour and then cotreated with 1 μM SN-38 for 2 hours. Cell lysates were then subjected to Western blot analysis. Data shown are representative of three independent experiments. Con, concentration.

    J Pharmacol Exp Ther 2014 348(3), 432-41. SN-38 purchased from Selleck.

  • CRC lung metastasis was established after iv injection of HT-29 LuM3 cells (1.5×106 cells in 100 μl of PBS). The polymeric nanoparticles loaded with PX866 and SN-38 were administered iv 72h after HT-29 LuM3 cells injection every q24h for 4 days and continued every q72h for 26 days (10 μg/g dose in 300 μl of PBS). PX866+SN−38 combination treatment was administered iv 72h after HT-29 LuM3 cells injection every q24h for 4 days (10 μg/g PX866 + 10 μg/g SN-38 mixed in 300 μl of PBS). Control: Empty PNP. Green: GFP expressing HT-29 LuM3 cells.

    J Control Release, 2018, 275:85-91. SN-38 purchased from Selleck.

  • Antiproliferative effects of SN-38 in vitro on 8305C (C) and FB3 (D) cell lines. The antiproliferative effects of the drugs were studied after 72 h of exposure. The data are presented as percentage of vehicle-treated cells. The concentrations of drug that reduced cell proliferation by 50% (IC50) vs controls were calculated by a nonlinear regression fit of the mean values of the data obtained in triplicate experiments (i.e. at least 9 wells for each concentration). Columns and bars, mean values ± S.E., respectively. *, P < 0.001 vs. control.

    Cancer Lett, 2017, 411:35-43. SN-38 purchased from Selleck.

  • (B) HCT116 cells were treated with increasing doses of SN-38 and treated with 4 nM SN-38 for different time. Cell extracts were prepared and analyzed by Western blotting with indicated antibody. These experiments were repeated thrice. (C) HCT116 cells were transfected with 2 μg of EGFP-LC3 construct. At 8 h post-transfection, cells were treated with 4 nM of SN-38 for 48 h. And then cells were examined by confocal microscopy (magnification × 400). The percentage of cells showing accumulation of EGFP-LC3 in puncta (EGFP-LC3vac) was quantified. (D) LOVO and HCT116 cells were treated with 2 nM and 4 nM of SN-38 combined with 10 mM of 3-Methyladenine (3-MA) for 48 h respectively. Cell extracts were prepared and analyzed by Western blotting with indicated antibody. These experiments were repeated thrice. (E) Cells were treated with indicated concentrations of 3-MA and SN-38 for 48 h. Cell apoptosis was assessed by Annexin V-FITC/PI staining assay by flow cytometry. Columns, means of three determinations; bars, SD. (F) and (G) LOVO and HCT116 cells were transfected with 50 nM of NC siRNA, ATG5 siRNA respectively, and then were treated with increasing doses of SN-38 for 48 h, the knockdown effects on ATG5 were confirmed by Western blot analysis (upper panel). Cell viability was measured using CCK8 assay. Columns, means of three determinations; bars, SD.

    Free Radic Biol Med, 2017, 104:280-297. SN-38 purchased from Selleck.

  • Following incubation of Hep3B cells with SN-38, mRNA expression levels of FUBP1 target genes (p21, BIK, CCND2 and TCTP) were significantly deregulated, whereas FUBP1 protein levels were not influenced.

    Biochem Pharmacol, 2017, 146:53-62. SN-38 purchased from Selleck.

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Choose Selective Topoisomerase Inhibitors

Biological Activity

Description SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
Targets
Topo I [1]
(Cell-free assay)
In vitro

SN-38, a biological active metabolite of irinotecan hydrochloride (CPT-11). SN-38 causes the strongest inhibition of DNA topoisomerase I, followed by CPT and then CPT-11. CPT-11 dose dependently shifts the position of relaxed DNA in the direction of nicked DNA, but SN-38 and CPT shows no effect on the position of relaxed DNA. SN-38 dose-dependently and time-dependently inhibit DNA synthesis. Respective IC50 values of SN-38, in DNA synthesis is 0.077 μM. The inhibitory effect of SN-38 on RNA synthesis is less than that on DNA synthesis and it does not inhibit protein synthesis. SN-38 caused frequent DNA single-strand breaks in P388 cells. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human PC6 cells M4f4O3Bzd2yrZnXyZZRqd25iYYPzZZk> MlTyOkBl[Xm| M3;3bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFO2JINmdGy|IHPhdpJ6cW6pIIDSR{Bi\nSncjC2JIRigXNuIFnDOVA:OC52MzDuUS=> MYGxPVI2PDh2Mx?=
human HCT116 cells Ml7IVJJwdGmoZYLheIlwdiCjc4PhfS=> NWDHVmtEOyCmYYnz NX24dng1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgN{Bl[Xm|LDDJR|UxRTBwNUWgcm0> NX;zUJBmOTl{NUS4OFM>
human PC3 cells MXXDfZRwfG:6aXRCpIF{e2G7 NFPCOHM4OiCq M{\weGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{BmgHC{ZYPzbY5oKGGucHjhOYJmfGF|IHnueIVoemmwIHHzd4V{e2WmIHHzJINmdGxic4Xyeol3[WxiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0zNjZibl2= M1;Cc|IzQTV7MkS2
human A549 cells NYXZNIRJS3m2b4TvfIlkyqCjc4PhfS=> NUn0V|lYOyCmYYnz MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFMh\GG7czDifUBUWkJiYYPzZZktKEmFNUC9Nk44OiCwTR?= NULyW25QOjR3Mkm4O|A>
human QG56 cells MmPGVJJwdGmoZYLheIlwdiCjc4PhfS=> NYDHfJI{OyCmYYnz M3zOSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUVe1OkBk\WyuczDh[pRmeiB|IHThfZMtKEmFNUC9Nk45KG6P M2D0Z|E6OjV2OESz
human NCI-H460 cells M1HjVnBzd2yrZnXyZZRqd25iYYPzZZk> NWi3d3E2OyCmYYnz MlPORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFQ3OCClZXzsd{Bi\nSncjCzJIRigXNuIFnDOVA:Oy5|IH7N M4jYd|E6OjV2OESz
human DU145 cells Mn;OVJJwdGmoZYLheIlwdiCjc4PhfS=> MnLlPVYhcA>? M2\FcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRGWxOFUh[2WubIOgZYZ1\XJiOU[gbJJ{NCCLQ{WwQVQhdk1? NV[0fVZUOTh{N{[xOFE>
human breast cancer cell line (SK-BR-3) M4XKTWN6fG:2b4jpZ:Kh[XO|YYm= M4jOcmlvKF[rdILvJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIJz\WG|dDDjZY5k\XJiY3XscEBtcW6nIDjTT{1DWi1|KTygTWM2OD12IH7N NG\MbmoyOTN|NEW2PS=>
human KB3-1 cells MmO0R5l1d3SxeHnjxsBie3OjeR?= NHW3fHY1KGSjeYO= NELzRVVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSjNvMTDj[YxteyCjZoTldkA1KGSjeYOgZpkhVVSWIH3leIhw\CxiSVO1NF01KG6P M1jVPFE6OzB|M{C2
human HCT116 cells NUfsfFRDS3m2b4TvfIlkyqCjc4PhfS=> NIXUOYQ4OiCq NV\xc3NCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBKSzVyPUSuNlghdk1? MmD3NlU5OzV|NUm=
MDA-MB-435 S human breast cancer cells NFnU[ZFHfW6ldHnvckBie3OjeR?= MYTJcohq[mm2aX;uJIFo[Wmwc4SgUWRCNU2ELUSzOUBUKGi3bXHuJIJz\WG|dDDjZY5k\XJiY3XscJMhcW5idHjlJIFje2WwY3Wgc4Yh[WykdX3pckwhUUN3ME21JI5O M2rhVlEyODV{OECy
human HT-29 cells MojhR5l1d3SxeHnjxsBie3OjeR?= MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{whUUN3ME21Mlkhdk1? NIXHb2czOTR5MEi2OC=>
human lung cancer cell line (H128) MXXDfZRwfG:6aXRCpIF{e2G7 MXvJckBXcXS{bzDjfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDseY5oKGOjbnPldkBk\WyuIHzpcoUhMEhzMkipMEBKSzVyPU[gcm0> M{jDWVEyOzN2NU[5
human MIA PaCa cells NX7sOmplWHKxbHnm[ZJifGmxbjDhd5NigQ>? NWjGWIx[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNTWEhWGGFYTDj[YxteyCjZoTldkA6PiCqcoOsJGlEPTB;NjDuUS=> NE\mWm4yQDJ5NkG0NS=>
human HCT116 colon cancer cell line NF\UbIRHfW6ldHnvckBie3OjeR?= NW[3W5VZUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOxbH;uJINidmOncjDj[YxtKGyrbnWsJGlEPTB;NzDuUS=> NWP0WHM4OTV6MEi0OVY>
human stomach cancer cell line (MKN45) MlPZR5l1d3SxeHnjxsBie3OjeR?= M4DZRWlvKF[rdILvJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJN1d22jY3igZ4Fv[2W{IHPlcIwhdGmwZTCoUWtPPDVrLDDJR|UxRThibl2= M17DNFEyOzN2NU[5
human A2780 cells MoDmR5l1d3SxeHnjxsBie3OjeR?= MkmyO|IhcA>? MmfER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMhd3[ncnX4dJJme3OrbnegZYxxcGF3YnX0ZVMhcW62ZXfybY4h[XO|ZYPz[YQh[XNiY3XscEB{fXK4aY\hcEBi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUmgcm0> NU\vXVRoOjJ7NUmyOFY>
human ovarian cancer cell line (SK-OV-3) MXfDfZRwfG:6aXRCpIF{e2G7 NWPKbY5RUW5iVnn0do8h[3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hd3[jcnnhckBk[W6lZYKgZ4VtdCCuaX7lJEhUUy2RVj2zLUwhUUN3ME2xNUBvVQ>? NEXo[FQyOTN|NEW2PS=>
human DU145 prostate cell line NIrRc|hRem:uaX\ldoF1cW:wIHHzd4F6 NHSyUWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KHC{b4P0ZZRmKGOnbHygcIlv\SxiSVO1NF0yOyCwTR?= MYexNFQ6QDJzNh?=
human colon cancer cell line (WiDr) MYXDfZRwfG:6aXRCpIF{e2G7 NEHQPYNKdiCYaYTyc{BkgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBkd2yxbjDjZY5k\XJiY3XscEBtcW6nIDjXbWRzMSxiSVO1NF0yPCCwTR?= NXXzSoRIOTF|M{S1Olk>
human lung cancer cell line (A549) NVnQWXBZS3m2b4TvfIlkyqCjc4PhfS=> M2XrWGlvKF[rdILvJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIx2dmdiY3HuZ4VzKGOnbHygcIlv\SBqQUW0PUk> NGflUJgyOTN|NEW2PS=>
human tumor HL60 cell-line NIXzUXdHfW6ldHnvckBie3OjeR?= MmTNN{Bl[Xm| M3vLeGlvNX[rdILvJIlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDmc5IhcHWvYX6geJVud3JiSFy2NEBk\WyuLXzpcoUhf2G|IHTleIVzdWmwZXSgeZNqdmdiU2LCJIF{e2G7IHHmeIVzKDNiZHH5d{Bw\iCrbnP1ZoF1cW:wLDDJR|UxRTF7IH7N Ml3pNVU6OTN7OU[=
PC-3 carcinoma cell line MnmzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3PBNWNwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDDndo94fGhib3[gbJVu[W5icILvd5RifGViUFOtN{Bk[XKlaX7vcYEh[2WubDDsbY5mNCCLQ{WwQVM2NjZibl2= NYjpUHRoOTV2NUSyN|A>
human KBV1 cells NX;ycWllS3m2b4TvfIlkyqCjc4PhfS=> MoPkOEBl[Xm| NXvRVmVYS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTSNUBwfmW{ZYjwdoV{e2mwZzDoeY1idiCNQm[xJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCPVGSgcYV1cG:mLDDJR|UxRTR4IH7N MnjXNVk{ODN|ME[=
human A549 cells NUTC[GlYS3m2b4TvfIlkyqCjc4PhfS=> NEPYT4pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{NCCLQ{WwQVQ4KG6P Mn7ZNlE1PzB6NkS=
NSCLC-H460 M2mzcmN6fG:2b4jpZ:Kh[XO|YYm= NIfBfGxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBvd25vc33hcIwu[2WubDDseY5oKGOjcnPpco9u[SClZXzsJIxqdmViSES2NEApVlOFTFOtTFQ3OCluIFnDOVA:QDBibl2= NXTFN2p{OTF3NkO5NlU>
MDA-MB-435 S human breast cancer cells M3TKUmZ2dmO2aX;uJIF{e2G7 M3Lwb2lvcGmkaYTpc44h[WejaX7zeEBOTEFvTVKtOFM2KFNiaIXtZY4h[nKnYYP0JINidmOncjDj[YxteyCrbjD0bIUheHKnc3XuZ4Uhd2ZiM{CgcYcwdUxiSGPBMEBKSzVyPUWwJI5O MmPSNVExPTJ6MEK=
human H460 cell NYThd4ZDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJGg1PjBiY3XscEBoem:5dHisJGlEPTB;OECgcm0> MoG2NVY6OTN5ME[=
human MDA-MB-231 cells MXjDfZRwfG:6aXRCpIF{e2G7 NEXQc5dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzMEBKSzVyPUG3OkBvVQ>? MkCzNlQ2Ojl6N{C=
human KBH5.0 cells MlGzR5l1d3SxeHnjxsBie3OjeR?= MkmxOEBl[Xm| M1LPRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEKFUmCgc5ZmemW6cILld5NqdmdiaIXtZY4hU0KKNT6wJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCPVGSgcYV1cG:mLDDJR|UxRTBwMzFOwG0> NWXSUoNFOTl|MEOzNFY>
human MCF-7 breast cell line NGn5No9Rem:uaX\ldoF1cW:wIHHzd4F6 MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRj23JIJz\WG|dDDj[YxtKGyrbnWsJGlEPTB;MD6zO{DPxE1? MV[xNFQ6QDJzNh?=
human SKOV-3 ovarian cell line M2\ZN3Bzd2yrZnXyZZRqd25iYYPzZZk> NFfhOFdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLU3YuOyCxdnHybYFvKGOnbHygcIlv\SxiSVO1NF0xNjd{IN88US=> M4HoU|ExPDl6MkG2
human Bel-7402 liver cancer cell line M{SwZ2Z2dmO2aX;uJIF{e2G7 MWnJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqdX3hckBD\WxvN{SwNkBtcX[ncjDjZY5k\XJiY3XscEBtcW6nLDDJR|UxRTNwMUmg{txO Ml;WNVU5ODh2NU[=
HEK293 cells NInRflFEgXSxdH;4bYPDqGG|c3H5 NE[xNFg4OiCq MmTaTY51emmwc3njJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> MUGyOVI4OjB3NR?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-Chk1 / Chk1 / Topo I ; 

PubMed: 18509065     


Log-phase Ovcar-5 cells were treated for 24 h with diluent (0.1% DMSO, lanes 1 and 6), gemcitabine at 12.5, 25, 50 or 100 nM (lanes 2-5, respectively), or SN-38 at 2.5, 5, 10, 20 and 40 nM in the absence (lanes 7-11) or presence (lanes 12-17) of 50 nM gemcitabine. At the end of the incubation, whole cell lysates were prepared, subjected to SDS-PAGE, transferred to nitrocellulose, and probed with reagents that recognize phospho-Ser345-Chk1, total Chk1, topo I or, as control, β-actin. Because of the limited number of lanes on our electrophoresis apparatus, lanes 1-5 and 6-17 represent two different membranes from the same experiment that were probed simultaneously.

18509065
Growth inhibition assay
Cell viability; 

PubMed: 25759163     


(A) Drug sensitivity towards SN‐38 and oxaliplatin for the parental and drug resistant cell lines. Cells were exposed to a range of drug concentrations for 48 h and cell viability was assessed by an endpoint MTT assay. Results of representative experiments are shown. Green (triangle) is the parental cell line, blue (diamond) the SN‐38 resistant cell line, and red (square) the oxaliplatin resistant cell line.

25759163
In vivo After oral dosing, peak SN-38 concentrations occurrs within 1 h, and the The percent unbound SN-38 lactone in murine plasma at 1000 ng/mL is 3.4 +/- 0.67%, whereas at 100 ng/mL the percent unbound is 1.18 +/- 0.14%. SN-38 lactone AUCs in micebearing human neuroblastoma xenografts are greater than in nontumor-bearing animals. [2]

Protocol

Kinase Assay:[1]
+ Expand

Topoisomerase I Assay:

One unit (the minimum amount for full relaxation of 0.5 μg SV40 DNA under the conditions of this study) of topoisomerase I, 0.5 μL of the test compounds, and 0.5μg SV40 DNA are added sequentially to the reaction buffer, which is composed of 25 mM Tris-HCl (pH 7.5), 50 mM KC1, 5 mM MgCl2, 0.25 mM EDTA disodium salt, 0.25 mM dithiothreitol, 15μg /mL bovine serum albumin, and 5% glycerol. Then, the reaction mixture (50 μL) is incubated for 10 min at 37 °C, and the reaction is terminated by treatment with 7.5 μL of a solution consisting of 1% sodium dodecyl sulfate, 20 mM EDTA disodium salt, and 0.5 mg/mL proteinase K for an additional 30 min at 37°C. The samples are mixed with 5 μL of the loading buffer containing 10 mM Na2HPO4, 31.3% sucrose, and 0.3% bromophenol blue. Relaxed (form Ir) DNA is separated from supercoiled (form I) and nicked (form II) DNA by electrophoresis on 0.8% agarose gel at 50 mA and 20 V for 17 h in the presence of 2 μg/mL chloroquine, 10 mM EDTA, 30 mM NaH2PO4, and 36 Mm Tris-HCl (pH 7.8). After electrophoresis, the gel is stained with 0.05% ethidium bromide and photographed with UV light (302 nm). The amount of DNA is quantified using a densitometer.
Cell Research:[3]
+ Expand
  • Cell lines: A-172, U-87, and LA-567
  • Concentrations: 0 -1000 nM
  • Incubation Time: 48 h
  • Method: MTT assay
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 21 mg/mL (53.51 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.4
Formula

C22H20N2O5

CAS No. 86639-52-3
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03995706 Recruiting Drug: Sacituzumab Govitecan Glioblastoma The University of Texas Health Science Center at San Antonio|Immunomedics Inc. July 17 2019 Early Phase 1
NCT03221400 Recruiting Drug: PEN-866 Sodium Carcinoma|Sarcoma|Endometrial Adenocarcinoma|Neoplasms|Squamous Cell Carcinoma of the Anus|Adenocarcinoma of the Pancreas|Advanced Cancer|Solid Tumor|Solid Carcinoma|Squamous Cell Carcinoma of the Cervix|Squamous Cell Carcinoma of the Head and Neck Tarveda Therapeutics August 29 2017 Phase 1|Phase 2
NCT03096340 Recruiting Drug: IT-141 Cancer|Neoplasms|Tumors|Refractory Solid Tumors|Recurrent Solid Tumors Intezyne Technologies Inc. March 23 2017 Phase 1
NCT02785068 Withdrawn Drug: MM-151|Drug: nal-IRI|Drug: Leucovorin|Drug: 5-FU Colorectal Cancer Merrimack Pharmaceuticals July 2016 Phase 1|Phase 2

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID