SB-3CT

For research use only.

Catalog No.S7430

15 publications

SB-3CT Chemical Structure

Molecular Weight(MW): 306.40

SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.

Size Price Stock Quantity  
USD 197 In stock
USD 497 In stock
USD 970 In stock
Bulk Discount
Bulk Inquiry

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's SB-3CT has been cited by 15 publications

4 Customer Reviews

  • The matrix metalloproteinase 9(MMP9) inhibitor(SB-3CT) attenuated angiotensin II (Ang II)-induced cardiomyocyte hypertrophy in vitro. (A) Representative immunofluorescent (α-actinin) images of neonatal rat cardiomyocytes (NRCMs) in the presence or absence of MMP9 inhibitor that were administered PBS or Ang II for 48 h. Bar=200 μm. (B) Statistical results for the cell surface area (CSA) of NRCMs. (C-E) The relative mRNA expression levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC) in NRCMs in the presence or absence of MMP9 inhibitor that were administered PBS or Ang II for 48 h. The intensities were normalized to the levels of GAPDH mRNA with the value in the PBS group defined as 1. * P<0.05 versus the control group, # P<0.05 versus the Ang II group. n=6 samples per experimental group

    Cell Physiol Biochem, 2017, 44(6):2281-2295. SB-3CT purchased from Selleck.

  • A) Inhibitory effect of SB‐3CT at the indicated concentrations against migration of HUVECs analyzed by a wound‐healing assay. These photos were obtained under fluorescence microscopy (×100) at 0 and 24 h after scraping. Bar = 200 μm.

    Mol Nutr Food Res, 2018, doi:10.1002/mnfr.201700969. SB-3CT purchased from Selleck.

  • B) Representative immunoblot and quantitative analysis of the effect of SB-3CT on the decrease in claudin-5 (25 kDa) and (C) AQP4 (35 kDa) expressions induced by MDMA at 1 h (n=4-6).

    Neuropharmacology, 2017, 118:157-166. SB-3CT purchased from Selleck.

  • EdU assays of directly co-cultured EOC cells with or without SB-3CT were performed. EOC cells cultured alone were used as controls. SB-3CT mediated MMP2/9 inhibition partially offset the proliferation-promoting effects of ADSCs in EOC.

    Exp Cell Res, 2018, 337(1):16-27. SB-3CT purchased from Selleck.

Purity & Quality Control

Choose Selective MMP Inhibitors

Biological Activity

Description SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.
Targets
MMP-2 [1]
(Cell-free assay)		 MMP-9 [1]
(Cell-free assay)
13.9 nM(Ki) 600 nM(Ki)
In vitro

SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro. [3]
Assay
Methods Test Index PMID
Western blot
Claudin11 / Occludin / ZO1 / Laminin-γ3 / β1-integrin ; 

PubMed: 19828778     


In vitro, primary rat Sertoli cell-germ cell cocultures are treated with SB-3CT (0, 5, and 10 μM) in the presence of MEHP for 12 h. The protein levels of claudin11, occludin, ZO1, laminin-γ3, and β1-integrin in primary rat Sertoli cell-germ cell cocultures are determined by Western blot analysis. ACTB serves as the loading control. 

19828778
In vivo In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. [2] SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. [3] In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion. [4]

Protocol

Animal Research:[2]
- Collapse
  • Animal Models: Mouse L-CI.5s T-cell lymphoma model
  • Dosages: 50 mg/kg/d
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 61 mg/mL (199.08 mM)
Ethanol 10 mg/mL warmed (32.63 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+corn oil
For best results, use promptly after mixing. 		10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 306.40
Formula

C15H14O3S2
CAS No. 292605-14-2
Storage powder
in solvent
Synonyms N/A
Smiles C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
selleck catalog

MMP Signaling Pathway Map

Related MMP Products

  • Marimastat (BB-2516) New

    Marimastat (BB-2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.

  • Calpeptin New

    Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells.

  • Ledipasvir (GS5885) New

    Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.

  • Nobiletin

    Nobiletin (Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.

  • Batimastat (BB-94)

    Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.

  • Ilomastat (GM6001, Galardin)

    Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.

  • NSC 405020

    NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.

  • MG-132

    MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 μM and 1.2 μM for the inhibition of proteasome and calpain, respectively. MG132 activates autophagy and induces apoptosis in tumor cells.

  • Bortezomib (PS-341)

    Bortezomib (PS-341, LDP-341, MLM341) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

  • Carfilzomib (PR-171)

    Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.

Tags: buy SB-3CT | SB-3CT supplier | purchase SB-3CT | SB-3CT cost | SB-3CT manufacturer | order SB-3CT | SB-3CT distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID