For research use only.
Catalog No.S7868 Synonyms: S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine
CAS No. 979-92-0
S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.
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|Description||S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.|
S-Adenosyl-L-homocysteine (SAH) shows strong inhibitory effects on METTL3-14 activity with an IC50 value of 0.9 ± 0.1 μM. While the presence of S-Adenosyl-L-homocysteine has no significant effects on ALKBH5 activity.
|In vitro||DMSO||77 mg/mL (200.3 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02998229||Not yet recruiting||Device: Artisse™||Intracranial Aneurysm||Medtronic Neurovascular Clinical Affairs||November 2021||Not Applicable|
|NCT04507178||Not yet recruiting||Drug: Nadroparin Injectable Product||Aneurysmal Subarachnoid Hemorrhage|Delayed Cerebral Ischemia||Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)||October 1 2021||Phase 2|
|NCT04998370||Recruiting||--||Subarachnoid Hemorrhage Aneurysmal|Vasospasm|Delayed Cerebral Ischemia|Delayed Ischemic Neurological Deficit||University of Zurich||August 2021||--|
|NCT01865630||Withdrawn||Drug: Etanercept||Subarachnoid Hemorrhage Aneurysmal||Unity Health Toronto||January 2021||Phase 1|
|NCT04384198||Recruiting||Procedure: Sonolysis||Mitral Valve Insufficiency||Charite University Berlin Germany|Berlin Institute of Health||August 13 2020||Not Applicable|
|NCT04440618||Recruiting||--||Obstructive Sleep Apnea-hypopnea|Oropharyngeal Cancer||Poitiers University Hospital||July 30 2020||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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