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S-Adenosyl-L-Homocysteine (SAH) METTL3-14 Inhibitor

Name: S-Adenosyl-L-Homocysteine (SAH)
Brand: Selleck Chemicals
SKU: S7868
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.S7868

SAH (S-Adenosyl-L-homocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.

S-Adenosyl-L-Homocysteine (SAH) Histone Methyltransferase inhibitor Chemical Structure

Quality Control

Batch: S786801 DMSO]77 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.94%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS/MSDS
Datasheet

99.94

Related Targets	HDAC JAK BET PKC PARP HIF PRMT EZH2 AMPK Histone Acetyltransferase
Other Histone Methyltransferase Inhibitors	Pinometostat (EPZ5676) 3-Deazaneplanocin A (DZNep) Hydrochloride BIX-01294 Trihydrochloride EPZ015666 (GSK3235025) UNC1999 EPZ004777 MM-102 (HMTase Inhibitor IX) Chaetocin SGC 0946 EPZ005687

Solubility

In vitro
Batch:

DMSO : 77 mg/mL (200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (13.01mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	384.41	Formula	C₁₄H₂₀N₆O₅S	Storage (From the date of receipt)	3 years -20°C(in the dark) powder 1 year -80°C(in the dark) in solvent
CAS No.	979-92-0	--		Storage of Stock Solutions	Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.
Synonyms	S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine			SMILES	NC(CCSCC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N)C(O)=O

Read more about storage stability CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	METTL3-14 (Cell-free assay) 0.9 μM
In vitro	S-Adenosyl-L-homocysteine (SAH) shows strong inhibitory effects on METTL3-14 activity with an IC50 value of 0.9 ± 0.1 μM, while it has no significant effects on ALKBH5 activity.
References	[1] https://pubmed.ncbi.nlm.nih.gov/26701100/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-23)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date
NCT06803043	ENROLLING_BY_INVITATION	Domestic Violence; Post Traumatic Stress Disorder	Boston University	2025-02-13
NCT07761520	NOT_YET_RECRUITING	Aneurysmal Subarachnoid Hemorrhage	Centre Hospitalier Universitaire de Nice	2026-09
NCT06735261	NOT_YET_RECRUITING	Subarachnoid Hemorrhage in Adult Patients	University Hospital, Grenoble	2025-04-01
NCT06526247	RECRUITING	Intimate Partner Violence	Boston University	2024-11-18
NCT03845205	RECRUITING	Alcohol Use Disorder; Alcoholic Hepatitis	Johns Hopkins University	2020-11-20
NCT04578249	RECRUITING	Circadian Rhythm Disorders	West Virginia University	2021-09-20

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