S-Adenosyl-L-homocysteine (SAH)

Catalog No.S7868 Synonyms: S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine

For research use only.

S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.

S-Adenosyl-L-homocysteine (SAH) Chemical Structure

CAS No. 979-92-0

Purity & Quality Control

Choose Selective Histone Methyltransferase Inhibitors

Biological Activity

Description S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.
Targets
METTL3-14 [1]
(Cell-free assay)
0.9 μM
In vitro

S-Adenosyl-L-homocysteine (SAH) shows strong inhibitory effects on METTL3-14 activity with an IC50 value of 0.9 ± 0.1 μM. While the presence of S-Adenosyl-L-homocysteine has no significant effects on ALKBH5 activity.[1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 77 mg/mL
(200.3 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 384.41
Formula

C14H20N6O5S

CAS No. 979-92-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05132920 Recruiting Drug: Dexamethasone|Drug: Placebo Aneurysmal Subarachnoid Hemorrhage University Hospital Bonn|German Federal Ministry of Education and Research|Pharmacy of the University Hospital Leipzig- AöR|nextevidence GmbH December 3 2021 Phase 3
NCT05103566 Not yet recruiting Device: gammaCore Subarachnoid Hemorrhage Aneurysmal Massachusetts General Hospital|ElectroCore INC December 2021 Not Applicable
NCT02998229 Not yet recruiting Device: Artisse™ Intracranial Aneurysm Medtronic Neurovascular Clinical Affairs November 2021 Not Applicable
NCT04507178 Not yet recruiting Drug: Nadroparin Injectable Product Aneurysmal Subarachnoid Hemorrhage|Delayed Cerebral Ischemia Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) October 1 2021 Phase 2
NCT04998370 Recruiting -- Subarachnoid Hemorrhage Aneurysmal|Vasospasm|Delayed Cerebral Ischemia|Delayed Ischemic Neurological Deficit University of Zurich August 18 2021 --
NCT01865630 Withdrawn Drug: Etanercept Subarachnoid Hemorrhage Aneurysmal Unity Health Toronto January 2021 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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