S-Adenosyl-L-homocysteine (SAH)

For research use only.

Catalog No.S7868 Synonyms: S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine

S-Adenosyl-L-homocysteine (SAH) Chemical Structure

CAS No. 979-92-0

S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.

Purity & Quality Control

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Biological Activity

Description S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.
Targets
METTL3-14 [1]
(Cell-free assay)
0.9 μM
In vitro

S-Adenosyl-L-homocysteine (SAH) shows strong inhibitory effects on METTL3-14 activity with an IC50 value of 0.9 ± 0.1 μM. While the presence of S-Adenosyl-L-homocysteine has no significant effects on ALKBH5 activity.[1]

Protocol

Solubility (25°C)

In vitro DMSO 77 mg/mL (200.3 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 384.41
Formula

C14H20N6O5S

CAS No. 979-92-0
Storage powder
in solvent
Synonyms S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02998229 Not yet recruiting Device: Artisse™ Intracranial Aneurysm Medtronic Neurovascular Clinical Affairs November 2021 Not Applicable
NCT04507178 Not yet recruiting Drug: Nadroparin Injectable Product Aneurysmal Subarachnoid Hemorrhage|Delayed Cerebral Ischemia Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) October 1 2021 Phase 2
NCT04998370 Recruiting -- Subarachnoid Hemorrhage Aneurysmal|Vasospasm|Delayed Cerebral Ischemia|Delayed Ischemic Neurological Deficit University of Zurich August 2021 --
NCT01865630 Withdrawn Drug: Etanercept Subarachnoid Hemorrhage Aneurysmal Unity Health Toronto January 2021 Phase 1
NCT04384198 Recruiting Procedure: Sonolysis Mitral Valve Insufficiency Charite University Berlin Germany|Berlin Institute of Health August 13 2020 Not Applicable
NCT04440618 Recruiting -- Obstructive Sleep Apnea-hypopnea|Oropharyngeal Cancer Poitiers University Hospital July 30 2020 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Histone Methyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID