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Swertiamarin

Cat.No.S3927

Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities.
Swertiamarin Chemical Structure

Chemical Structure

Molecular Weight: 374.34

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S392701 DMSO]74 mg/mL]false]]]false]]]false Purity: 99.76%
99.76

Chemical Information, Storage & Stability

Molecular Weight 374.34 Formula

C16H22O10

 Storage (From the date of receipt)
CAS No. 17388-39-5 -- Storage of Stock Solutions

Synonyms Swertiamaroside Smiles C=CC1C(OC=C2C1(CCOC2=O)O)OC3C(C(C(C(O3)CO)O)O)O

Solubility

In vitro
Batch:

DMSO : 74 mg/mL (197.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vivo
Pharmacokinetic analysis shows that Swertiamarin is absorbed very fast, with very short plasma half-life of 1.3 h, and is completely eliminated from systemic circulation after 4-5 h. This compound treatment has no significant effect on adipogenesis, or the mRNA expression of PPAR-g and GLUT-4; however, there is a significant increase in the mRNA expression of adiponectin[1]. On treatment, it exerts an antiinflammatory effect on macrophages and neutrophils by suppressing the release of free radicals, iNOS expression, and proinflammatory cytokines. It acts as an anti-inflammatory agent by suppressing proinflammatory mediators (Th1) and inducing anti-inflammatory mediators (Th2)[2]. This chemical decreases serum cholesterol levels and reduces the oxidation of LDL. In addition, it has also shown to have the ability in increasing the HDL levels and reduction in the ratio of LDL/HDL cholesterol. It has shown to modulate 5-HT2 receptor and hypolipidemic potential in animal models of depression, diabetes and obesity[3].
References

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