Sotagliflozin (LX4211)

For research use only.

Catalog No.S8103

2 publications

Sotagliflozin (LX4211) Chemical Structure

Molecular Weight(MW): 424.94

Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.

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Biological Activity

Description Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.
SGLT2 [1] SGLT1 [1]
1.8 nM 36 nM
In vitro

LX4211 inhibits [14C]AMG uptake with IC50 of 62.0 nM for mouse SGLT1 and 0.6 nM for mouse SGLT2, respectively. [2]

In vivo In mice, LX4211 (60 mg/kg, p.o.) reduces intestinal glucose absorption by inhibiting SGLT1, resulting in net increases in GLP-1 and PYY release and decreases in GIP release and blood glucose excursions. [2] In nonobese diabetes-prone mice with type 1 diabetes, Sotagliflozin (30 mg/kg) significantly improves glycemic control, without increasing the rate of hypoglycemia measurements. [3]


Animal Research:[2]
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  • Animal Models: Male albino C57BL/6-Tyrc-Brd mice
  • Dosages: ~60 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 84 mg/mL (197.67 mM)
Ethanol 17 mg/mL warmed (40.0 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 424.94


CAS No. 1018899-04-1
Storage powder
in solvent
Synonyms N/A
Smiles CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)C3OC(SC)C(O)C(O)C3O)C=C1

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03174548 Completed Drug: Sotagliflozin (SAR439954) Diabetes Mellitus Sanofi June 12 2017 Phase 1
NCT03070678 Completed Drug: Sotagliflozin (SAR439954)|Drug: Mefenamic acid Diabetes Mellitus Sanofi March 14 2017 Phase 1
NCT02926937 Completed Drug: Sotagliflozin (SAR439954)|Drug: Placebo Type 2 Diabetes Mellitus Lexicon Pharmaceuticals|Sanofi November 11 2016 Phase 3
NCT01292993 Completed Drug: 400 mg LX4211|Drug: 1000 mg metformin Type 2 Diabetes Mellitus Lexicon Pharmaceuticals February 2011 Phase 1

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SGLT Signaling Pathway Map

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