Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

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In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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Cited by 20 Publications

4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017, 7:41404. Stattic purchased from Selleck.

    (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

  • LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 M4TQWWZ2dmO2aX;uJGF{e2G7 NGH6[pYyOOLCid88US=> NGXndmo16oDLaB?= M4jFUpJmfmW{c3XzJJRp\SCnZn\lZ5R{KG:oIFnMMVI4 NH;WR3MzPjN|OU[zNy=>
NPC  NVjXTmF2TnWwY4Tpc44hSXO|YYm= M4HGWVAuPy53INM1US=> MWDhZo9tcXOqZYOgSW1VNWyra3WgcY9t\WO3bHHyJIFtfGW{YYTpc45{NCCjbnSgZ4VtdCCvaXfyZZRqd25iYX7kJIlvfmG|aX;uJIlv\HWlZXSgZpkhWkuLUDDrco9kc2Sxd36= MorZNlU6OTV2M{C=
HASMC Ml\NSpVv[3Srb36gRZN{[Xl? MUKxMlI2NTVizszN NYLiOmxSOjBibXnu Mn;1SG1UV8Li NFHRe5ZqdmirYnn0d{BxNSi\KT3TWGFVNTFuMzy1JJNq\26jbIRCpC=> NW[xd3djOjV6NEm2NlI>
H9c2  M4TkcmZ2dmO2aX;uJGF{e2G7 NYPT[ZpxOi9zMDFOwG0> MlTlNkBp NFrGZWxFVVORwrC= NI\Kb4Zi[nKxZ3H0[ZPDqHSqZTDjfZRweHKxdHXjeIl3\SCnZn\lZ5R{KG:oIFnMMVI4KGGpYXnud5QhW0h? MnHLNlU5OjB7MEe=
A431 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXmTHIzyqEQvF2= MmXBNuKhcA>? NGjxSoNjdG:la4OgSWdHNXKndnXyd4VlKGSnY4LlZZNmeyCrbjDj[YxtKH[rYXLpcIl1gQ>? NUX2[FFCOjV5MkC0N|U>
A431 M4fQXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfsd2trOsLizszN MljUNuKhcA>? M{HiWYlv[3KnYYPld{BqdiCjcH;weI9{cXNiaX7keYNm\CCkeTDzbIlsd26rbh?= M{XzWlI2PzJyNEO1
SiHa NE\NSFBE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NUHwSIhCPS15NTDuUS=> MoGzNlTDqGkEoB?= Mkn4d4hwf3NibX;ydIhwdG:peTDv[kBiKHS7cHnjZYwh[XCxcITveIlkKGOnbHygZY5lKGSxc3Wt[IVx\W6mZX70JIxwe3Nib3[gZ4VtdCC4aXHibYxqfHoEoB?= NF3LcFkzPTV|OU[0OC=>
SiHa MYrGeY5kfGmxbjDBd5NigQ>? M1vhPVUuPzVibl2= M2LG[VI1yqCqwrC= NFj2UWpz\WS3Y3XzJJRp\cLicHjvd5Bpd3K7bHH0bY9vKGG2IITo[UB1gXKxc3nu[UBz\XOrZIXlJFcxPcLi MVqyOVU{QTZ2NB?=
ECA109 M2HGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVywMVIxKM7:TR?= MkmzNlTDqGkEoB?= MWLJR|UxRTVwNUCg{txO MWSyOVQ6OjR6MB?=
TE13 NF36N5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDRNE0zOCEQvF2= MmHHNlTDqGkEoB?= NVu1[lVZUUN3ME22MlE2yqEQvF2= NFXLe4YzPTR7MkS4NC=>
KYSE150  M2DiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLobVIxNTJyIN88US=> M{DpRVI1yqCqwrC= NI\FU4lKSzVyPUGyMlY1yqEQvF2= MXSyOVQ6OjR6MB?=
ECA109 M2PVRWNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= NUnpZYxmOC53wrFOwG0> NU\RNZJHOjUEoHlCpC=> M{KxZZN2eHC{ZYPz[ZMhfGinIHPsc45w\2WwaXOg[o9zdWG2aX;u MonjNlU1QTJ2OEC=
TE13 M2P5OGNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= MkCyNE42yqEQvF2= MnjaNlTDqGkEoB?= MY\zeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= NVq4Z2tDOjV2OUK0PFA>
KYSE150  NEj0S5VEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 MkL5NE42yqEQvF2= NIn1c3czPMLiaNMg Moe4d5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= MnmzNlU1QTJ2OEC=
ECA109 NYiyVGU{TnWwY4Tpc44hSXO|YYm= MkfONE42yqEQvF2= NFz6VIMzPMLiaNMg MYjlcohidmOnczDJVk1qdmS3Y3XkJIdmdmW{YYTpc44hd2ZiRGPCdy=> NYDnN5lPOjV2OUK0PFA>
PC3M-1E8 MWPGeY5kfGmxbjDBd5NigQ>? Mon4Nk42NzVxMUCg{txO M4rhWlAuPCCq NHzsPWxqdmirYnn0d{B1cGViU2TBWFMh[WO2aY\heIlwdiCrbjDhJIRwe2VvIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XMEoB?= M1;GUVI2OjZzM{[1
PC3M-1E8 M37STGZ2dmO2aX;uJGF{e2G7 M4G0TFExKM7:TR?= NXnEOGk4OjRiaB?= Ml7K[I94dnKnZ4XsZZRmeyCEY3ytfGwtKHO3co\peolvKGGwZDDjMW16[w>? NWHDdVdKOjV{NkGzOlU>
PC3M-1E8 Mn7kSpVv[3Srb36gRZN{[Xl? MW[xNEDPxE1? NUT1eGpDOjRiaB?= MmPobY5pcWKrdIOgTWwuPiCrbnT1Z4VlKFOWQWSzJIFkfGm4YYTpc44h[W6mIITo[UBKVC14LXnu[JVk\WRiU2TBWFMh[WO2aY\heIlwdg>? NIjyWGkzPTJ4MUO2OS=>
PC3M-1E8 MojaR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= MVqyMlUwPS9zMDFOwG0> NX\aSYp3cW6qaXLpeJPDqHSqZTDjc4xwdnliZn;ycYF1cW:wIIPp[45q\mmlYX70cJk> MWWyOVI3OTN4NR?=
MDA-MB-231 MYDGeY5kfGmxbjDBd5NigQ>? MnjvNlAh|ryP NUPCRmtUOiCq NIL4TGdmgGirYnn0d{BUdmGrbDDhcoQhTS2lYXTo[ZJqdiCneIDy[ZN{cW:w MV:yOVE2OzN2OR?=
H9c2 NVvHTHBYTnWwY4Tpc44hSXO|YYm= M1\FfVIxKML3TR?= NIDGb2w{OCCvaX6= MmjySG1UV8Li Mo\QZYJwdGm|aHXzJJBzd3CxZn;sMYlv\HWlZXSgRWtVKHCqb4PwbI9zgWyjdHnvckBifCCkb4ToJJNmejR5MzDhcoQhfGi{M{C4 MVqyOVExPTB4Nx?=
HaCaT  NWnabYcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2xZVZyOTBiwsXN NFe3WZQzOCCvaX6= NYjpR4Y1TE2VT9Mg NIP6UGJmdmijbnPld{B{d3KjZnXubYIuKGGwZDDzeY5qfGmwaXKtbY5lfWOnZDDndo94fGhiaX7obYJqfGmxbh?= MVmyOVAyOzlyNx?=
Caki-1 NE\DRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTHb21{OTBiwsXN MWeyNEBucW5? Mlz3SG1UV8Li M4exS4VvcGGwY3XzJJNwemGoZX7pZk0h[W6mIIP1col1cW6rYj3pcoR2[2WmIHfyc5d1cCCrbnjpZol1cW:w MnK1NlUxOTN7MEe=
HaCaT  NUHWeFc6SXCxcITvd4l{KEG|c3H5 NYTPeVB7OTBiwsXN NGLs[|YzOCCvaX6= M4rub2ROW00EoB?= NHL3NlJqdmO{ZXHz[ZMheHKxcH;yeIlwdnNib3[gZZBweHSxdHnjJINmdGy|IHT1[UB1dyC2cnXheI1mdnRid3n0bEB{d3KjZnXubYIhd3Jic4XubZRqdmmk NFP1eWkzPTBzM{mwOy=>
FHL-primed hNSCs MoPVR4VtdCCYaXHibYxqfHliQYPzZZk> MlHYNE4xOi13IN88US=> NVjBS3JMPzJiaB?= MWXs[YFleyC2bzD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDheEBpcWeqIHPvcoNmdnS{YYTpc44> M{XWOFI1QTR3NEO0
ELL-primed hNSCs NH\JcWxE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1TzdFAvODJvNTFOwG0> M1vHeFczKGh? MmLHcIVi\HNidH:geIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZZQhcGmpaDDjc45k\W62cnH0bY9v NFPxPFUzPDl2NUSzOC=>
SS M135S2NmdGxiVnnhZoltcXS7IFHzd4F6 MWGxMVExKM7:TR?= NWnGWYppPzJiaB?= MkPzSG1UVw>? M2XCVoNifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg NEDq[lYzPDd3NkGxNS=>
SeAx  MnjBR4VtdCCYaXHibYxqfHliQYPzZZk> NHKwOZoyNTFyIN88US=> NVvUSottPzJiaB?= NEG4WZJFVVOR MW\jZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= NXfNNplsOjR5NU[xNVE>
HuT-78 NXf6cHNqS2WubDDWbYFjcWyrdImgRZN{[Xl? MVexMVExKM7:TR?= NF31NVk4OiCq M{jjVWROW09? MXvjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= NWfVSFhSOjR5NU[xNVE>
CD4+ MX\BdI9xfG:|aYOgRZN{[Xl? NVXESm1POTEkgJpOwI0> Ml;MNlQhcA>? MlqxSG1UVw>? MYfpcoR2[2W|IHHwc5B1d3OrczDzeJJwdmeueR?= M4DmW|I1PzV4MUGx
MCF-7 Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWwMlQ3QS1|Lke1JO69VQ>? MU[1JIQ> MmjPdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MVqyOFczQDB5OB?=
MCF-7/LCC1 M1;4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PJeFAvPDZ7LUOuO|Uh|ryP NHuwcmg2KGR? MWny[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? MkjpNlQ4OjhyN{i=
MCF-7/LCC9 NGn0U4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXQNE41PjlvMz63OUDPxE1? MYW1JIQ> MoHIdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MVmyOFczQDB5OB?=
HaCaT NFmwbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mwdlExKML3TR?= M2nnXVIxKG2rbh?= Mkj6SG1UV8Li MYLlcohidmOnczDleoVzd2yrbYXzMYlv\HWlZXSgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdg>? NFnj[5IzPDR{M{GzNS=>
HaCaT NVPU[ItXSXCxcITvd4l{KEG|c3H5 MlTXNVAhyrWP MXmyNEBucW5? Ml:5SG1UV8Li MVzlcohidmOnczD0bIUh[XCxcITveIlkKGWoZnXjeJMhd2ZiZY\ldo9tcW23cx?= NXPBbnIxOjR2MkOxN|E>
MDA-MB-231 Mn7MSpVv[3Srb36gRZN{[Xl? NUnkPWFUOTBiwsXN NF;IZXIzPCCq MX\EUXNQyqB? M33pOZJm\HWlZYOgVE1UXEGWMzDlfJBz\XO|aX;u NHLBcGwzPDN5NkW4Oi=>
SUM-159 NIr1c2hHfW6ldHnvckBCe3OjeR?= MmnwNVAhyrWP NWHubHhkOjRiaB?= Ml7iSG1UV8Li NH;aWllz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> MoTvNlQ{PzZ3OE[=
SK-BR-3 NGHGfpNHfW6ldHnvckBCe3OjeR?= NITtU5oyOCEEtV2= M{Pq[FI1KGh? M1TLVmROW00EoB?= NEfIUWxz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> Ml3pNlQ{PzZ3OE[=
MCF7-HER2 M4Xqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVqwMVExKM7:TR?= NUDMR2N2PDhiaB?= NV\Fd2ZZTE2VTx?= MYDpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= MoX0NlQzQTd3MEi=
MCF7-HER2 NYXyXWp3TnWwY4Tpc44hSXO|YYm= MVS1JO69VQ>? Ml;6NlQhcA>? NF3uRm1FVVOR Mon0[IlucW6rc3jld{BUd3hvMjygU4N1NTRuIHHu[EB{dHWpIHX4dJJme3Orb36= MUeyOFI6PzVyOB?=
MCF7-HER2 NEnHR3ZHfW6ldHnvckBCe3OjeR?= MlzROUDPxE1? NUfvdlFEOjRiaB?= MkDrSG1UVw>? NGD4OFNl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wy|IH;mJGVOXCCvYYLr[ZJ{NCC4aX3lcpRqdiCjbnSgd4x2\w>? MVeyOFI6PzVyOB?=
MCF7-HER2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTCRpBwPSEQvF2= M2iz[FI1KGh? NFzCbHhFVVOR M3z3d4VvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iY3;tZolv\WRid3n0bEBJ\XKlZYD0bY4> M1\lOVI1Ojl5NUC4
HMECs  NFvFN4VHfW6ldHnvckBCe3OjeR?= MnHWNVAh|ryP MojvNkBp NUC0eo1DcW6qaXLpeJMhUU[QzsJCpI1m\GmjdHXkJJBpd3OyaH;yfYxifGmxbjDv[kBUXEGWMTygV3RCXDJiYX7kJHNVSVR| MXOyOFIyOTN{Nx?=
HTR8/SVneo MoPaSpVv[3Srb36gRZN{[Xl? NF\teHkyyqEQvF5CpC=> MVOxxsBp MnXod5VxeHKnc4Pl[EBQW01vaX7keYNm\CCVVFHUN{BxcG:|cHjvdplt[XSrb36= Mnq0NlQxPjB{NEG=
HTR8/SVneo MWTGeY5kfGmxbjDBd5NigQ>? Ml:xNE42NzIEoN88UeKh NX;1d5RbPDhiaB?= MVPy[ZN1d3KnczD0bIUh\XiycnXzd4lwdiCxZjDFMYNi\GincnnuJJN2eHC{ZYPz[YQh[nliT2PN NUfkRZd{OjRyNkCyOFE>
HTR8/SVneo MkfkSpVv[3Srb36gRZN{[Xl? NYrpPWNDOcLizszNxsA> NEPTbYU1QCCq MnfMd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNibXnndoF1cW:wIHL5JG9UVcLi M4G4clI1ODZyMkSx
C13* M33XSWFxd3C2b4Ppd{BCe3OjeR?= M1qydFAuOTBizszN NI\WO4szPC92ODDo Mn3JbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= MXiyN|k3OjV3OB?=
OV2008 NIDWe3lCeG:ydH;zbZMhSXO|YYm= MWiwMVExKM7:TR?= NFjxfFUzPC92ODDo MmW1bY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= MoTQNlM6PjJ3NUi=
C13* M{TpeWFxd3C2b4Ppd{BCe3OjeR?= NYPKcHpWOjRxNEigbC=> NGfYeHJmdmijbnPld{BkcXOybHH0bY4ucW6mdXPl[EBieG:ydH;zbZM> MYKyN|k3OjV3OB?=
OV2008 MVnBdI9xfG:|aYOgRZN{[Xl? NIj2NmwzPC92ODDo MoSx[Y5p[W6lZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZZBweHSxc3nz MVKyN|k3OjV3OB?=
W480  NWXQPWd3TnWwY4Tpc44hSXO|YYm= M1u2dlIvPS9zMDFOwG0> M4XJfVMxKG2rbh?= NUHPSlRNTE2VTx?= NV\ZZnNle2Wwc3n0bZpmeyClZXzsd{B1dyClaHXtc5Ji\GmxdHjldoFxgSCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? M1LNclI{QTN2OUey
SW837 MU\GeY5kfGmxbjDBd5NigQ>? NGnIWIIzNjVxMUCg{txO MWWzNEBucW5? NVnSdXZKTE2VTx?= MX3z[Y5{cXSrenXzJINmdGy|IITvJINp\W2xcnHkbY91cGW{YYD5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M{j6eFI{QTN2OUey
T24 M1j6[2Z2dmO2aX;uJGF{e2G7 NVj1N5FwOi9zMD:yNEDPxE1? MX2yOEBp MoX3Z4F2e2W|IHTvd4Uu\GWyZX7k[Y51KGmwaHnibZRqd25ib3[geIhmKEO[Q1yxNk1qdmS3Y3XkJIlv[3KnYYPlJI9nKGmwdnHkbY5oKGOnbHzz NFixNGczOzV{NkC3PS=>
CNE1 NFGxVYtHfW6ldHnvckBCe3OjeR?= MYGyNEDDvU1? NVPOS3lwPDhiaB?= MW\icI9kc3NidHjlJGlNNTZiaX7jdoVie2WmIIDoc5NxcG:{eXzheIlwdiCxZjDTeIF1Ow>? MWmyN|M5OjlzNB?=
CNE2 NXKyW3JvTnWwY4Tpc44hSXO|YYm= M{f4d|IxKML3TR?= NXOybYE4PDhiaB?= MYDicI9kc3NidHjlJGlNNTZiaX7jdoVie2WmIIDoc5NxcG:{eXzheIlwdiCxZjDTeIF1Ow>? M37oVVI{Ozh{OUG0
HONE1 MnPpSpVv[3Srb36gRZN{[Xl? MVWyNEDDvU1? MmfSOFghcA>? M3jJN4Jtd2OtczD0bIUhUUxvNjDpcoNz\WG|ZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJHN1[XR| NUXIV3BvOjN|OEK5NVQ>
CNE1 M1ntS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33qZVQh|ryP M3naXpNq\26rZnnjZY51dHlicnXkeYNmeyClZXzsJJZq[WKrbHn0fS=> NFTm[3gzOzN6MkmxOC=>
CNE1 Mom2SpVv[3Srb36gRZN{[Xl? MWGwMVIxKM7:TR?= MnHxNE01KGh? NV7Uc21CcW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> M4\3bVI{Ozh{OUG0
CNE2 NGjlfHNHfW6ldHnvckBCe3OjeR?= MUGwMVIxKM7:TR?= MoqzNE01KGh? NF3HRmJqdmirYnn0d{BUfGG2MzDhZ5RqfmG2aX;uJIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> NYLQXIVpOjN|OEK5NVQ>
HONE1 NI\WcVZHfW6ldHnvckBCe3OjeR?= M13id|AuOjBizszN NXPsZnVbOC12IHi= MlO1bY5pcWKrdIOgV5RifDNiYXP0bZZifGmxbjDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NUjvcYZyOjN|OEK5NVQ>
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CNE2 MVvD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NF\nR2gxNjVvNkSg{txO MUS0PEBp MUjzeZBxemW|c3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NHXNdXozOzN6MkmxOC=>
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HONE1 NXO3[FRJSXCxcITvd4l{KEG|c3H5 NXfjOol1OTBiwsXNxsA> MX20PEBp NFexWZRqdmS3Y3XzJIFxd3C2b4Ppd:Kh NEntbVIzOzN6MkmxOC=>
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HONE1 M1PlOmNmdGxiVnnhZoltcXS7IFHzd4F6 M3jPclEwOiEQvF2= NV7kbXRXPDhiaB?= MVzz[Y5{cXSrenWgZ4VtdHNidH:gdoFlcW:2aHXyZZB6 M{DOeFI{Ozh{OUG0
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HEC-1A NF3jSpNHfW6ldHnvckBCe3OjeR?= M3nlfFHDqM7:TdMg M1jVXFI1KGh? M2rNNmROW09? MnG2Zoxw[2u|IITo[UBOXUN{MD3lcohidmOnZDDpcpZie2mxbjD0dolo\2W{ZXSgZpkhTUeIwrC= Mnv5NlMzPjJ{MEi=
RL95-2 MWXGeY5kfGmxbjDBd5NigQ>? NH7nZ20yyqEQvF5CpC=> M2fIU|I1KGh? MmL3SG1UVw>? NInPVY5jdG:la4OgeIhmKE2XQ{KwMYVvcGGwY3XkJIlvfmG|aX;uJJRzcWepZYLl[EBjgSCHR1dCpC=> M4DqN|I{OjZ{MkC4
CT26 NUjGNW9WTnWwY4Tpc44hSXO|YYm= MViyNEBuVQ>? MVSxJIg> MYXzeZBxemW|c3XzJGhITi2rbnT1Z4VlKF[HR1[g[ZhxemW|c3nvcuKh NEHxU3QzOzJ|M{G2Ny=>
UM-SCC-17B Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4OwTGlEPTB;Mj61OlIhyrFiMD60NFkh|ryPLDDHTVUxRTFwMke5JOKyKDBwMUm0JO69VQ>? MljQNlI4PzB6OUm=
OSC-19 Mn;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf2TWM2OD1|LkS4NUDDuSByLkm1N{DPxE1uIFfJOVA:OS5|Nk[gxtEhOC55N{Cg{txO NIDGd|EzOjd5MEi5PS=>
Cal33 NFLaUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwMkiyJOKyKDBwNEKzJO69VSxiR1m1NF0yNjN2OTFCtUAxNjN4MzFOwG0> NE\Xc2EzOjd5MEi5PS=>
UM-SCC-22B MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPDO|FKSzVyPUKuOlQ5KMLzIECuOVQzKM7:TTygS2k2OD1zLkOyNEDDuSByLkKwOEDPxE1? MV2yNlc4ODh7OR?=
UM-SCC-17B MWrGeY5kfGmxbjDBd5NigQ>? MlTmNE0{OCEQvF2= MnWxNE0zPCCq NETrflBqdmirYnn0d{BUXEGWMzDhZ5RqfmG2aX;uJIRwe2ViYX7kJJRqdWViZHXw[Y5l\W62bIm= MWmyNlc4ODh7OR?=
OSC-19 NYjqVIdzTnWwY4Tpc44hSXO|YYm= NV7XNVlwOC1|MDFOwG0> NUj3VFV[OC1{NDDo NFrTcm9qdmirYnn0d{BUXEGWMzDhZ5RqfmG2aX;uJIRwe2ViYX7kJJRqdWViZHXw[Y5l\W62bIm= NW\zdphCOjJ5N{C4PVk>
Cal33 MlXJSpVv[3Srb36gRZN{[Xl? NF3VeoMxNTNyIN88US=> MWOwMVI1KGh? NITBT|hqdmirYnn0d{BUXEGWMzDhZ5RqfmG2aX;uJIRwe2ViYX7kJJRqdWViZHXw[Y5l\W62bIm= NFzPbXAzOjd5MEi5PS=>
UM-SCC-22B Mm\RSpVv[3Srb36gRZN{[Xl? M{\q[|AuOzBizszN NHK0S5ExNTJ2IHi= MYrpcohq[mm2czDTWGFVOyCjY4TpeoF1cW:wIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51dHl? NF;lPIYzOjd5MEi5PS=>
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U-373MG M1nDTmNmdGxiVnnhZoltcXS7IFHzd4F6 M2PSVlAuOTBizszN MVu3NkBp MlvESG1UVw>? NUK5U3Z{cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= M3rJXlI2PDN4Nkiy
SH-SY5Y MWTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M{j2dlAuOTBizszN MYW3NkBp M2\vUWROW09? NVfvZWk1cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= M1PaUlI2PDN4Nkiy
Tu-9648 NGKyT3pE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NV2yNWl6OC1zMDFOwG0> MlrvO|IhcA>? MVTEUXNQ NGWydIpqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 MYGyOVQ{PjZ6Mh?=
Neuro-2a NXLCUFd4S2WubDDWbYFjcWyrdImgRZN{[Xl? MkG5NE0yOCEQvF2= NVnIUW9KPzJiaB?= MmLRSG1UVw>? M1XWXolvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? M3TEdVI2PDN4Nkiy
PCNs MVnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M{TCb|AuOTBizszN NXvS[pBpPzJiaB?= NXLKb5BQTE2VTx?= MXjpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 Ml\MNlU1OzZ4OEK=
PGCs MoPFR4VtdCCYaXHibYxqfHliQYPzZZk> M1zBTlAuOTBizszN M33zV|czKGh? M{L3e2ROW09? NInxPIlqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 MlfvNlU1OzZ4OEK=
RAW264.7 MUnGeY5kfGmxbjDBd5NigQ>? MlvpNVAh|ryP MnroNVIhcA>? M3XKfIFjem:pYYTld{B1cGVibWLORUBmgHC{ZYPzbY9veyCxZjDKRWszNCCVVFHUNUwhW1SDVEKsJIFv\CCVVFHUN{BqdmS3Y3XkJIJ6KESRTjDhcoQhXC1{IITvfIlv M3LYN|IzPDV2NEOx
RAW264.7 NXThSJB3SXCxcITvd4l{KEG|c3H5 MYe1M|ExKM7:TR?= NV7NWnZoPDVibXnu NGPqO3RmdmijbnPld{B1d3irboOgbY5lfWOnZDDhdI9xfG:|aYOgZY5lKE2PUDDsc5N{ M1rL[FIzPDV2NEOx
SW480 MUPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MYe1M|ExNzJyIN88US=> NHLHeXc4OiCq NUm1SotScW6qaXLpeJMh[2WubDD2bYFjcWyrdImgc4YhfGinIFHMSGgsN0OGMUOzL:Kh[2WubIO= M33n[lIyQTByM{m3
HCT116 NIDmclNE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3fkVVUwOTBxMkCg{txO NI\TRlM4OiCq M1TWZYlvcGmkaYTzJINmdGxidnnhZoltcXS7IH;mJJRp\SCDTFTIL{9ETDF|MzxCpINmdGy| MXGyNVkxODN7Nx?=
DLD-1  NUnvR4NxS2WubDDWbYFjcWyrdImgRZN{[Xl? M3POblUwOTBxMkCg{txO MVi3NkBp NInyXoRqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDv[kB1cGViQVzETEswS0RzM{OrxsBk\Wyucx?= MoH2NlE6ODB|OUe=
SNU387  MmLDR4VtdCCYaXHibYxqfHliQYPzZZk> M2LmdFIxyqEQvF5CpC=> NH;GZnozPCCq NELWUlJz\WS3Y3XzJINmdGxidnnhZoltcXS7 MYqyNVMyOTl5NR?=
SNU398 MUnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M37UdVIxyqEQvF5CpC=> Ml7WNlQhcA>? M{[wd5Jm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MnryNlE{OTF7N{W=
HepG2 MnHrR4VtdCCYaXHibYxqfHliQYPzZZk> NVTlfVMyOjEEoN88UeKh M2\sTVI1KGh? MlzudoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? M1fNNlIyOzFzOUe1
Huh-7 MW\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MVuyNOKh|ryPwrC= NF7rOG4zPCCq M1rLS5Jm\HWlZYOgZ4VtdCC4aXHibYxqfHl? NVXXWolOOjF|MUG5O|U>
VSMC NITFVppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYizM|UwOTBizszN M1;CcFMxKG2rbh?= NXK4[INCTE2VTx?= MlzRdJJmfmWwdIOgVGRITi1iYX7kJJRpem:vYnnuMY1m\GmjdHXkJHZUVUNicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MXWyNFg1PzNyNh?=
MDA-MB-231 MWjBdI9xfG:|aYOgRZN{[Xl? NY\VOZJZOTBizszN NGLEfmEzPCCq NUKzXJpKTE2VT9Mg MnmzbY5lfWOnczDhdI9xfG:|aYO= M1:wcVE4OTF2MEC1
MDA-MB-435S NFXjNo5CeG:ydH;zbZMhSXO|YYm= M1jrOlExKM7:TR?= NVvuUG9LOjRiaB?= MmnaSG1UV8Li MmnPbY5lfWOnczDhdI9xfG:|aYO= M1K2O|E4OTF2MEC1

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+H2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID