Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

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In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017, 7:41404. Stattic purchased from Selleck.

    (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

  • LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 NEHoWIlHfW6ldHnvckBCe3OjeR?= MYCxNQKBkc7:TR?= NGDIepM16oDLaB?= NYmxd4xbemW4ZYLz[ZMhfGinIHXm[oVkfHNib3[gTWwuOjd? NEP0V3MzPjN|OU[zNy=>
NPC  M{HtSGZ2dmO2aX;uJGF{e2G7 MX[wMVcvPSEEtV2= NWLySXhw[WKxbHnzbIV{KEWPVD3sbYtmKG2xbHXjeYxieiCjbITldoF1cW:wczygZY5lKGOnbHygcYloemG2aX;uJIFv\CCrbo\hd4lwdiCrbnT1Z4VlKGK7IGLLTXAhc26xY3vkc5dv NXP5ZlJ4OjV7MUW0N|A>
HASMC MYjGeY5kfGmxbjDBd5NigQ>? M{LRdFEvOjVvNTFOwG0> MYeyNEBucW5? MkS4SG1UV8Li Mn\YbY5pcWKrdIOgdE0pYSlvU2TBWE0yNDNuNTDzbYdv[Wy|wrC= MUCyOVg1QTZ{Mh?=
H9c2  MWrGeY5kfGmxbjDBd5NigQ>? M{\0fVIwOTBizszN Mn7kNkBp MlvMSG1UV8Li NGrvZnpi[nKxZ3H0[ZPDqHSqZTDjfZRweHKxdHXjeIl3\SCnZn\lZ5R{KG:oIFnMMVI4KGGpYXnud5QhW0h? MofGNlU5OjB7MEe=
A431 M1XROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPGPFgzyqEQvF2= M1LzT|LDqGh? NIrsbWxjdG:la4OgSWdHNXKndnXyd4VlKGSnY4LlZZNmeyCrbjDj[YxtKH[rYXLpcIl1gQ>? MYWyOVczODR|NR?=
A431 NH;GdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf1NuKh|ryP M4[3WlLDqGh? MkfmbY5kemWjc3XzJIlvKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIPobYtwdmmw MmLUNlU4OjB2M{W=
SiHa M1XSWmNmdGxiVnnhZoltcXS7IFHzd4F6 MUi1MVc2KG6P MVOyOOKhcMLi NF[1eJR{cG:5czDtc5JxcG:ub3f5JI9nKGFidInwbYNidCCjcH;weI91cWNiY3XscEBidmRiZH;z[U1l\XCnbnTlcpQhdG:|czDv[kBk\WyuII\pZYJqdGm2edMg MVuyOVU{QTZ2NB?=
SiHa M4i1cWZ2dmO2aX;uJGF{e2G7 MY[1MVc2KG6P Ml\nNlTDqGkEoB?= NUXhO3FYemWmdXPld{B1cGYEoIDoc5NxcG:{eXzheIlwdiCjdDD0bIUhfHm{b4PpcoUhemW|aXT1[UA4ODYEoB?= NYjjeHJlOjV3M{m2OFQ>
ECA109 NVPqZ2lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWqwMVIxKM7:TR?= M4r0R|I1yqCqwrC= MXPJR|UxRTVwNUCg{txO NGLyUY4zPTR7MkS4NC=>
TE13 NVjNenF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnoToVYOC1{MDFOwG0> NFPyUpczPMLiaNMg NVjv[YM2UUN3ME22MlE2yqEQvF2= MnrsNlU1QTJ2OEC=
KYSE150  NUPPeI1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHTNE0zOCEQvF2= MlHzNlTDqGkEoB?= NIDobnFKSzVyPUGyMlY1yqEQvF2= MVKyOVQ6OjR6MB?=
ECA109 NHvZbWdEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 MWSwMlXDqM7:TR?= MkHwNlTDqGkEoB?= NWrWXJFre3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> MXGyOVQ6OjR6MB?=
TE13 NWXRT5BnS2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> MkK0NE42yqEQvF2= MkG2NlTDqGkEoB?= MVfzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= NEPMfpYzPTR7MkS4NC=>
KYSE150  M32zUGNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= M2fYelAvPcLizszN M1v5[lI1yqCqwrC= NV\SXlZ3e3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> NETSVZozPTR7MkS4NC=>
ECA109 MXLGeY5kfGmxbjDBd5NigQ>? M1vqS|AvPcLizszN NVX3clg6OjUEoHlCpC=> NUDLbGlR\W6qYX7j[ZMhUVJvaX7keYNm\CCpZX7ldoF1cW:wIH;mJGRUSnN? NXzwS4pyOjV2OUK0PFA>
PC3M-1E8 NGXMZYhHfW6ldHnvckBCe3OjeR?= NE\WSGEzNjVxNT:xNEDPxE1? NYXoXolbOC12IHi= M1;5PYlvcGmkaYTzJJRp\SCVVFHUN{Bi[3SrdnH0bY9vKGmwIHGg[I9{\S1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5mesLi M3jQO|I2OjZzM{[1
PC3M-1E8 MmfRSpVv[3Srb36gRZN{[Xl? MXKxNEDPxE1? Ml;YNlQhcA>? MXrkc5dvemWpdXzheIV{KEKlbD34UEwhe3W{dnn2bY4h[W6mIHOtUZlk MYqyOVI3OTN4NR?=
PC3M-1E8 Mmf3SpVv[3Srb36gRZN{[Xl? MUCxNEDPxE1? MkH0NlQhcA>? MXnpcohq[mm2czDJUE03KGmwZIXj[YQhW1SDVEOgZYN1cX[jdHnvckBidmRidHjlJGlNNTZvaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9v MXeyOVI3OTN4NR?=
PC3M-1E8 NVT5PG1kS2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> MkP0Nk42NzVxMUCg{txO NWDQVop2cW6qaXLpeJPDqHSqZTDjc4xwdnliZn;ycYF1cW:wIIPp[45q\mmlYX70cJk> M3;UR|I2OjZzM{[1
MDA-MB-231 MnHFSpVv[3Srb36gRZN{[Xl? M{mwfFIxKM7:TR?= NILQWokzKGh? NUm2OoFx\XiqaXLpeJMhW26jaXygZY5lKEVvY3HkbIVzcW5iZYjwdoV{e2mxbh?= MoDUNlUyPTN|NEm=
H9c2 MV3GeY5kfGmxbjDBd5NigQ>? MkK2NlAhyrWP MVKzNEBucW5? NF21cnNFVVORwrC= NIfGRlhi[m:uaYPo[ZMheHKxcH;mc4wucW6mdXPl[EBCU1RicHjvd5Bpd3K7bHH0bY9vKGG2IHLveIghe2W{NEezJIFv\CC2aIKzNFg> M{HWNlI2OTB3ME[3
HaCaT  M3zzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHneFEyOCEEtV2= NFuzOlEzOCCvaX6= Mlj3SG1UV8Li NX7OcnJV\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= M3jMWFI2ODF|OUC3
Caki-1 M3zNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XTcFExKML3TR?= NWTDXVJGOjBibXnu M3LtUWROW00EoB?= MnjG[Y5p[W6lZYOgd49z[W[nbnniMUBidmRic4XubZRqdmmkLXnu[JVk\WRiZ4Lve5RpKGmwaHnibZRqd25? MmLSNlUxOTN7MEe=
HaCaT  MYLBdI9xfG:|aYOgRZN{[Xl? MmfuNVAhyrWP MX6yNEBucW5? NYfD[|dvTE2VT9Mg NX2wbVc2cW6lcnXhd4V{KHC{b4DvdpRqd26|IH;mJIFxd3C2b4TpZ{Bk\WyuczDkeYUhfG9idILlZZRu\W62IIfpeIghe2:{YX\lcoljKG:{IIP1col1cW6rYh?= NEHh[FIzPTBzM{mwOy=>
FHL-primed hNSCs NXSydnpqS2WubDDWbYFjcWyrdImgRZN{[Xl? NGTUbpUxNjB{LUWg{txO MkPrO|IhcA>? M1G2cYxm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? NFjRdZIzPDl2NUSzOC=>
ELL-primed hNSCs NGXnUm9E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYHLc3pmOC5yMj21JO69VQ>? NXm5XXl{PzJiaB?= NEPv[5Bt\WGmczD0c{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBifCCqaXfoJINwdmOnboTyZZRqd25? NXL3SJlVOjR7NEW0N|Q>
SS MoK4R4VtdCCYaXHibYxqfHliQYPzZZk> NILqNmEyNTFyIN88US=> M4HnZlczKGh? MX;EUXNQ NVHzZ2Rr[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> NUDJUGZtOjR5NU[xNVE>
SeAx  NXK5bpdwS2WubDDWbYFjcWyrdImgRZN{[Xl? NWXyNogzOS1zMDFOwG0> MomxO|IhcA>? NW[zbI85TE2VTx?= NUDJfWE4[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> M2j6cFI1PzV4MUGx
HuT-78 NVnk[|BxS2WubDDWbYFjcWyrdImgRZN{[Xl? M17Ud|EuOTBizszN NVfIS2VkPzJiaB?= MkWxSG1UVw>? NWjYRWFK[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> MV[yOFc2PjFzMR?=
CD4+ NI[wSWdCeG:ydH;zbZMhSXO|YYm= MkTpNVDjiIoQvH2= M4DQbFI1KGh? M2XRV2ROW09? NYG0bmwycW6mdXPld{BieG:ydH;zbZMhe3S{b37ncJk> NHzXWlYzPDd3NkGxNS=>
MCF-7 NGnzXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:wUYxlOC52NkmtN{44PSEQvF2= NXzmeZN1PSCm MXXy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? NUXDdJBLOjR5MkiwO|g>
MCF-7/LCC1 M3OyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDKNE41PjlvMz63OUDPxE1? MX:1JIQ> MUjy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? MlniNlQ4OjhyN{i=
MCF-7/LCC9 M1\kRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH4NE41PjlvMz63OUDPxE1? M3q2N|Uh\A>? MoLYdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 M37qT|I1PzJ6MEe4
HaCaT MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTEfoZ[OTBiwsXN MojNNlAhdWmw NH64PWxFVVORwrC= MnW0[Y5p[W6lZYOg[ZZmem:uaX31d{1qdmS3Y3XkJINmdGxiZ4Lve5RpKGmwaHnibZRqd25? NV\HeIdIOjR2MkOxN|E>
HaCaT NWC5OXdNSXCxcITvd4l{KEG|c3H5 NWSxT|hZOTBiwsXN M2Xme|IxKG2rbh?= NFnHc3dFVVORwrC= NHzNTm9mdmijbnPld{B1cGViYYDvdJRwfGmlIHXm[oVkfHNib3[g[ZZmem:uaX31dy=> MnrKNlQ1OjNzM{G=
MDA-MB-231 MYjGeY5kfGmxbjDBd5NigQ>? MUWxNEDDvU1? NHzFNJEzPCCq NVTsWGtxTE2VT9Mg NIfFfJJz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> NELZbmEzPDN5NkW4Oi=>
SUM-159 NYT3[|M{TnWwY4Tpc44hSXO|YYm= MofFNVAhyrWP M3;XPFI1KGh? MnrjSG1UV8Li NGHvUFZz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> M{TqbVI1Ozd4NUi2
SK-BR-3 MYTGeY5kfGmxbjDBd5NigQ>? NELvTVMyOCEEtV2= NWn6O4lGOjRiaB?= NXTnb3RmTE2VT9Mg NHXI[2pz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> MkDSNlQ{PzZ3OE[=
MCF7-HER2 Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDoeZl2OC1zMDFOwG0> M1u0TFQ5KGh? M2TjUWROW09? NUC0SIF[cW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> M3HiTVI1Ojl5NUC4
MCF7-HER2 M4nyRWZ2dmO2aX;uJGF{e2G7 NHLY[pc2KM7:TR?= MVKyOEBp MXXEUXNQ MWXkbY1qdmm|aHXzJHNwgC1{LDDPZ5QuPCxiYX7kJJNtfWdiZYjwdoV{e2mxbh?= M3ToN|I1Ojl5NUC4
MCF7-HER2 MX\GeY5kfGmxbjDBd5NigQ>? NWXyS|doPSEQvF2= NIrHe|QzPCCq MYnEUXNQ Mmjm[IVkemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVteyCxZjDFUXQhdWG{a3Xyd{whfmmvZX70bY4h[W6mIIPseYc> M2LGUVI1Ojl5NUC4
MCF7-HER2 NGrkZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPHfJM2KM7:TR?= MXuyOEBp MVXEUXNQ MYHlcohidmOnczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGOxbXLpcoVlKHerdHigTIVz[2WydHnu MYWyOFI6PzVyOB?=
HMECs  NIm1O|lHfW6ldHnvckBCe3OjeR?= NI\hT|QyOCEQvF2= NUnVUWljOiCq NF;PbJZqdmirYnn0d{BKTk8QsdMgcYVlcWG2ZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJHNVSVRzLDDTWGFVOiCjbnSgV3RCXDN? M3zDNlI1OjFzM{K3
HTR8/SVneo MX\GeY5kfGmxbjDBd5NigQ>? NVTC[pl1OcLizszNxsA> MlfyNeKhcA>? NVHDXo1ke3WycILld5Nm\CCRU12tbY5lfWOnZDDTWGFVOyCyaH;zdIhwenmuYYTpc44> MYiyOFA3ODJ2MR?=
HTR8/SVneo NI\s[lRHfW6ldHnvckBCe3OjeR?= NIjGWpQxNjVxMdMg{txOyqB? MoTrOFghcA>? MmDmdoV{fG:{ZYOgeIhmKGW6cILld5Nqd25ib3[gSU1k[WSqZYLpckB{fXCycnXzd4VlKGK7IF;TUS=> MVyyOFA3ODJ2MR?=
HTR8/SVneo NF7QVXpHfW6ldHnvckBCe3OjeR?= Mn\UNeKh|ryPwrC= Mn35OFghcA>? Mmjhd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNibXnndoF1cW:wIHL5JG9UVcLi NX3Vb5ZQOjRyNkCyOFE>
C13* M4T5SWFxd3C2b4Ppd{BCe3OjeR?= NHPndGExNTFyIN88US=> NYTMd5pvOjRxNEigbC=> NXXoSGVkcW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfCCvYX7u[ZI> NXLBcVN3OjN7NkK1OVg>
OV2008 M2DnOmFxd3C2b4Ppd{BCe3OjeR?= M2XjWFAuOTBizszN NUDq[VR{OjRxNEigbC=> MX3pcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3WgZY5lKHSrbXWg[IVx\W6mZX70JI1idm6nch?= NV7oTHVROjN7NkK1OVg>
C13* M17QO2Fxd3C2b4Ppd{BCe3OjeR?= Mkn6NlQwPDhiaB?= NWnrWoJQ\W6qYX7j[ZMh[2m|cHzheIlvNWmwZIXj[YQh[XCxcITvd4l{ M1;JVVI{QTZ{NUW4
OV2008 Mk\mRZBweHSxc3nzJGF{e2G7 NVflTGlIOjRxNEigbC=> M1\GVoVvcGGwY3XzJINqe3CuYYTpck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NFqySmwzOzl4MkW1PC=>
W480  M3fJPWZ2dmO2aX;uJGF{e2G7 NFvUcWQzNjVxMUCg{txO MXizNEBucW5? NIjXZmpFVVOR M1S5TZNmdnOrdHn6[ZMh[2WubIOgeI8h[2inbX;yZYRqd3SqZYLhdJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M4DWc|I{QTN2OUey
SW837 M3PwZ2Z2dmO2aX;uJGF{e2G7 M17kdVIvPS9zMDFOwG0> NYPjPXd2OzBibXnu NEXqfWNFVVOR Mmnwd4Vve2m2aYrld{Bk\WyuczD0c{BkcGWvb4Lh[IlwfGincnHwfUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M1PJO|I{QTN2OUey
T24 NGnrb3FHfW6ldHnvckBCe3OjeR?= NVrwbIN6Oi9zMD:yNEDPxE1? M4XZc|I1KGh? NV;vXIhq[2G3c3XzJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinIFPYR2wyOi2rbnT1Z4VlKGmwY4LlZZNmKG:oIHnueoFlcW6pIHPlcIx{ MVKyN|UzPjB5OR?=
CNE1 MlP6SpVv[3Srb36gRZN{[Xl? M3r3[lIxKML3TR?= NUTvfphKPDhiaB?= NUG4O2hm[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NHuwNnozOzN6MkmxOC=>
CNE2 NGP6WHNHfW6ldHnvckBCe3OjeR?= NYPkWG1HOjBiwsXN M3TEflQ5KGh? NY\ke|FN[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NEf1N4IzOzN6MkmxOC=>
HONE1 MUfGeY5kfGmxbjDBd5NigQ>? MWKyNEDDvU1? NHW1bGE1QCCq NE\UfYJjdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= MmnrNlM{QDJ7MUS=
CNE1 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fHVVQh|ryP M{PGbpNq\26rZnnjZY51dHlicnXkeYNmeyClZXzsJJZq[WKrbHn0fS=> NFPlOZEzOzN6MkmxOC=>
CNE1 NFfuXVRHfW6ldHnvckBCe3OjeR?= M1nmRlAuOjBizszN M4joblAuPCCq M3vYRYlvcGmkaYTzJHN1[XR|IHHjeIl3[XSrb36gbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy MojzNlM{QDJ7MUS=
CNE2 NE\FNW9HfW6ldHnvckBCe3OjeR?= M1n4V|AuOjBizszN M4fiOFAuPCCq NEfuTJNqdmirYnn0d{BUfGG2MzDhZ5RqfmG2aX;uJIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> NXWxZlRXOjN|OEK5NVQ>
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HONE1 NV[xZ5B5S2WubDDWbYFjcWyrdImgRZN{[Xl? MoLCNE42NTZ2IN88US=> M3HtSVQ5KGh? MoTwd5VxeHKnc4Pld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NWniSmg3OjN|OEK5NVQ>
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CNE1 NGHFdIdCeG:ydH;zbZMhSXO|YYm= NV\QXZQ{OTBiwsXNxsA> NVO4UWlCPDhiaB?= MXvpcoR2[2W|IHHwc5B1d3Orc9Mg Mor5NlM{QDJ7MUS=
CNE2 MkPFRZBweHSxc3nzJGF{e2G7 MVyxNEDDvU4EoB?= Mny4OFghcA>? M4D3eYlv\HWlZYOgZZBweHSxc3nzxsA> NFTZc44zOzN6MkmxOC=>
HONE1 NFyzOIJCeG:ydH;zbZMhSXO|YYm= M4TSXVExKML3TdMg M3L3RlQ5KGh? NXXaOoRCcW6mdXPld{BieG:ydH;zbZPDqA>? Mn;XNlM{QDJ7MUS=
CNE2 MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MlLPNU8zKM7:TR?= MoLlOFghcA>? NXy4c2JEe2Wwc3n0bZpmKGOnbHzzJJRwKHKjZHnveIhmemGyeR?= NGLjXXMzOzN6MkmxOC=>
HONE1 M3;iVGNmdGxiVnnhZoltcXS7IFHzd4F6 MVqxM|Ih|ryP NI[5V|g1QCCq MVnz[Y5{cXSrenWgZ4VtdHNidH:gdoFlcW:2aHXyZZB6 MmLoNlM{QDJ7MUS=
C666-1  MV7D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NG\2N3YyNzJizszN NGLFOoo1QCCq MmHtd4Vve2m2aYrlJINmdGy|IITvJJJi\GmxdHjldoFxgQ>? NX;ROHpIOjN|OEK5NVQ>
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HEC-1A M1P2fGZ2dmO2aX;uJGF{e2G7 NF7pdZIyyqEQvF5CpC=> NV\5VY9YOjRiaB?= M2fCN2ROW09? Mnm5Zoxw[2u|IITo[UBOXUN{MD3lcohidmOnZDDpcpZie2mxbjD0dolo\2W{ZXSgZpkhTUeIwrC= M1TRN|I{OjZ{MkC4
RL95-2 M1PFemZ2dmO2aX;uJGF{e2G7 MlzvNeKh|ryPwrC= Ml\xNlQhcA>? NVPLVYNnTE2VTx?= MmPXZoxw[2u|IITo[UBOXUN{MD3lcohidmOnZDDpcpZie2mxbjD0dolo\2W{ZXSgZpkhTUeIwrC= MXSyN|I3OjJyOB?=
CT26 NHLVRWtHfW6ldHnvckBCe3OjeR?= M4Dkc|IxKG2P NIexVWwyKGh? MlL4d5VxeHKnc4Pld{BJT0ZvaX7keYNm\CCYRVfGJIV5eHKnc4Ppc47DqA>? M3XIVVI{OjN|MU[z
UM-SCC-17B NYj2coZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHz[Wl{UUN3ME2yMlU3OiEEsTCwMlQxQSEQvF2sJGdKPTB;MT6yO|khyrFiMD6xPVQh|ryP MmS5NlI4PzB6OUm=
OSC-19 Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\IeGlEPTB;Mz60PFEhyrFiMD65OVMh|ryPLDDHTVUxRTFwM{[2JOKyKDBwN{ewJO69VQ>? NGDVWlAzOjd5MEi5PS=>
Cal33 NFLheVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofBTWM2OD1{LkK4NkDDuSByLkSyN{DPxE1uIFfJOVA:OS5|NEmgxtEhOC5|NkOg{txO M4nLXVIzPzdyOEm5
UM-SCC-22B NVi3VoZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrsTWM2OD1{Lk[0PEDDuSByLkW0NkDPxE1uIFfJOVA:OS5|MkCgxtEhOC5{MESg{txO MWWyNlc4ODh7OR?=
UM-SCC-17B NGXvdIZHfW6ldHnvckBCe3OjeR?= MWOwMVMxKM7:TR?= NInEc4sxNTJ2IHi= NYO4fGJ2cW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 NX31Rm12OjJ5N{C4PVk>
OSC-19 NGnUPWJHfW6ldHnvckBCe3OjeR?= NUnUTW9wOC1|MDFOwG0> NVnxOHRyOC1{NDDo MlHzbY5pcWKrdIOgV3RCXDNiYXP0bZZifGmxbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfGy7 MlHSNlI4PzB6OUm=
Cal33 M1:3UWZ2dmO2aX;uJGF{e2G7 NUD5[nBJOC1|MDFOwG0> NF3pcI4xNTJ2IHi= NIHRPI9qdmirYnn0d{BUXEGWMzDhZ5RqfmG2aX;uJIRwe2ViYX7kJJRqdWViZHXw[Y5l\W62bIm= M1jBVVIzPzdyOEm5
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U-87MG MXTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1vrPVAuOTBizszN NVnmZ3hWPzJiaB?= NXq2fIlJTE2VTx?= M3vhbolvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? MmnGNlU1OzZ4OEK=
U-373MG NYH4[3V[S2WubDDWbYFjcWyrdImgRZN{[Xl? NHvSSI0xNTFyIN88US=> NILnfIQ4OiCq M{XF[WROW09? M4\XOIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NVGzelc4OjV2M{[2PFI>
SH-SY5Y NFzQb2hE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MXqwMVExKM7:TR?= MWi3NkBp NW\DTpFxTE2VTx?= NX22O3Q6cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MlK1NlU1OzZ4OEK=
Tu-9648 MWTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NX\1fpduOC1zMDFOwG0> MVO3NkBp NFTkXnJFVVOR MYXpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 NFLqPIUzPTR|Nk[4Ni=>
Neuro-2a MX;D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1fPXFAuOTBizszN NFrUV2M4OiCq MV\EUXNQ M1e3dolvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? MWGyOVQ{PjZ6Mh?=
PCNs MnvZR4VtdCCYaXHibYxqfHliQYPzZZk> M3LueFAuOTBizszN NVq0XHI2PzJiaB?= MVnEUXNQ MUnpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 NIfGbm8zPTR|Nk[4Ni=>
PGCs Mle1R4VtdCCYaXHibYxqfHliQYPzZZk> NEDlb40xNTFyIN88US=> M1nqXlczKGh? M2n2fWROW09? MV\pcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 NWL3Znd1OjV2M{[2PFI>
RAW264.7 MXfGeY5kfGmxbjDBd5NigQ>? NWX2OHRKOTBizszN MUexNkBp NV7BOZg4[WK{b3fheIV{KHSqZTDtVm5CKGW6cILld5Nqd26|IH;mJGpCUzJuIGPURXQyNCCVVFHUNkwh[W6mIGPURXQ{KGmwZIXj[YQh[nliRF;OJIFv\CCWLUKgeI95cW5? M{PZXFIzPDV2NEOx
RAW264.7 NIDy[IlCeG:ydH;zbZMhSXO|YYm= NHHtcVQ2NzFyIN88US=> MWq0OUBucW5? NXzPOocx\W6qYX7j[ZMhfG:6aX7zJIlv\HWlZXSgZZBweHSxc3nzJIFv\CCPTWCgcI9{ew>? NYjDZXlEOjJ2NUS0N|E>
SW480 M4DKZmNmdGxiVnnhZoltcXS7IFHzd4F6 NILwU5U2NzFyL{KwJO69VQ>? M4HGSlczKGh? NGfi[YNqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDv[kB1cGViQVzETEswS0RzM{OrxsBk\Wyucx?= MlWwNlE6ODB|OUe=
HCT116 MYPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NX3jXVY4PS9zMD:yNEDPxE1? NFS2[nM4OiCq MlfSbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? NGnpU40zOTlyMEO5Oy=>
DLD-1  MmnvR4VtdCCYaXHibYxqfHliQYPzZZk> MVq1M|ExNzJyIN88US=> MX23NkBp NUnie5JJcW6qaXLpeJMh[2WubDD2bYFjcWyrdImgc4YhfGinIFHMSGgsN0OGMUOzL:Kh[2WubIO= M4rm[FIyQTByM{m3
SNU387  MljER4VtdCCYaXHibYxqfHliQYPzZZk> M4\lflIxyqEQvF5CpC=> NFnufZkzPCCq MnvKdoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? MX2yNVMyOTl5NR?=
SNU398 MkLjR4VtdCCYaXHibYxqfHliQYPzZZk> M3;DW|IxyqEQvF5CpC=> M1;sT|I1KGh? NEfyZmNz\WS3Y3XzJINmdGxidnnhZoltcXS7 MXmyNVMyOTl5NR?=
HepG2 MliwR4VtdCCYaXHibYxqfHliQYPzZZk> NVTpZpdyOjEEoN88UeKh NV3ndIRXOjRiaB?= NUfY[FNuemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= MlvzNlE{OTF7N{W=
Huh-7 NYf5WXF[S2WubDDWbYFjcWyrdImgRZN{[Xl? MXqyNOKh|ryPwrC= M2TnVFI1KGh? NVLSPGh[emWmdXPld{Bk\WyuII\pZYJqdGm2eR?= M3XhTlIyOzFzOUe1
VSMC M{fBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGflV2U{NzVxMUCg{txO NX\aXlNEOzBibXnu M2O2fmROW09? MoP6dJJmfmWwdIOgVGRITi1iYX7kJJRpem:vYnnuMY1m\GmjdHXkJHZUVUNicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MU[yNFg1PzNyNh?=
MDA-MB-231 NVWzb3RZSXCxcITvd4l{KEG|c3H5 MnnsNVAh|ryP MXKyOEBp NEH4OZpFVVORwrC= MYfpcoR2[2W|IHHwc5B1d3Orcx?= NU[2XJJrOTdzMUSwNFU>
MDA-MB-435S NG\P[2tCeG:ydH;zbZMhSXO|YYm= NF;tboUyOCEQvF2= NF6yRnMzPCCq MVfEUXNQyqB? M3vKVYlv\HWlZYOgZZBweHSxc3nz NYjnRZN4OTdzMUSwNFU>

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+H2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID