Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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Cited by 20 Publications

4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017, 7:41404. Stattic purchased from Selleck.

    (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

  • LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MoHaSpVv[3Srb36gRZN{[Xl? NXvsWIV1OTEkgJpOwG0> NVTJeZF{POLCiXi= M2iyWJJmfmW{c3XzJJRp\SCnZn\lZ5R{KG:oIFnMMVI4 NGrrN5AzPjN|OU[zNy=>
NPC  NW\lU2xnTnWwY4Tpc44hSXO|YYm= MX6wMVcvPSEEtV2= MmXGZYJwdGm|aHXzJGVOXC2uaXvlJI1wdGWldXzhdkBidHSncnH0bY9veyxiYX7kJINmdGxibXnndoF1cW:wIHHu[EBqdn[jc3nvckBqdmS3Y3XkJIJ6KFKNSWCgb45w[2umb4fu NWTYfmJWOjV7MUW0N|A>
HASMC MnL5SpVv[3Srb36gRZN{[Xl? NUD0Z21oOS5{NT21JO69VQ>? M1rPN|IxKG2rbh?= MXnEUXNQyqB? M4\2UolvcGmkaYTzJJAuMFlrLWPURXQuOSx|LEWgd4lodmGuc9Mg M2K4WlI2QDR7NkKy
H9c2  NFrzXnRHfW6ldHnvckBCe3OjeR?= NUPofWdSOi9zMDFOwG0> M1j2blIhcA>? M33wUmROW00EoB?= MX\hZpJw\2G2ZYRCpJRp\SCleYTvdJJwfGWldHn2[UBm\m[nY4TzJI9nKEmOLUK3JIFo[Wmwc4SgV2g> NEf2T3IzPTh{MEmwOy=>
A431 NYjKPJZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13rZlLDqM7:TR?= M2ro[|LDqGh? MV\icI9kc3NiRVfGMZJmfmW{c3XkJIRm[3KnYYPld{BqdiClZXzsJJZq[WKrbHn0fS=> NVr6bIxjOjV5MkC0N|U>
A431 MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYqyxsDPxE1? NGjvUnYzyqCq NWSyTXdvcW6lcnXhd4V{KGmwIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNpcWuxbnnu NH3XSWIzPTd{MESzOS=>
SiHa M2m5N2NmdGxiVnnhZoltcXS7IFHzd4F6 Mlj6OU04PSCwTR?= M1\xdFI1yqCqwrC= M4j6VJNpd3e|IH3vdpBpd2yxZ4mgc4Yh[SC2eYDpZ4FtKGGyb4D0c5Rq[yClZXzsJIFv\CCmb4PlMYRmeGWwZHXueEBtd3O|IH;mJINmdGxidnnhZoltcXS7wrC= MojLNlU2Ozl4NES=
SiHa NWn4WnNPTnWwY4Tpc44hSXO|YYm= MUG1MVc2KG6P NHq2WoIzPMLiaNMg MYHy[YR2[2W|IITo[eKheGixc4Doc5J6dGG2aX;uJIF1KHSqZTD0fZJwe2mwZTDy[ZNq\HWnIEewOeKh NXn2d|lHOjV3M{m2OFQ>
ECA109 NF;QcmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DST|AuOjBizszN NFO3Vm4zPMLiaNMg MWrJR|UxRTVwNUCg{txO NF;B[|IzPTR7MkS4NC=>
TE13 NIfnO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf2O5poOC1{MDFOwG0> M4Hu[VI1yqCqwrC= M4nMT2lEPTB;Nj6xOeKh|ryP Mn;oNlU1QTJ2OEC=
KYSE150  MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfRNE0zOCEQvF2= MYCyOOKhcMLi NWTTWo5rUUN3ME2xNk43PMLizszN M3XnW|I2PDl{NEiw
ECA109 M2XBSGNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= M4PadFAvPcLizszN MWKyOOKhcMLi NWLufWxGe3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> MorsNlU1QTJ2OEC=
TE13 MVnDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 NXr1RZlMOC53wrFOwG0> NGD0TVEzPMLiaNMg MUHzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= M2ftR|I2PDl{NEiw
KYSE150  M4H5N2Ntd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= Mn7FNE42yqEQvF2= NFPDdowzPMLiaNMg MUTzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= M1zIN|I2PDl{NEiw
ECA109 NV\XUJg2TnWwY4Tpc44hSXO|YYm= M1fDe|AvPcLizszN M1PGV|I1yqCqwrC= MWrlcohidmOnczDJVk1qdmS3Y3XkJIdmdmW{YYTpc44hd2ZiRGPCdy=> MYmyOVQ6OjR6MB?=
PC3M-1E8 MYPGeY5kfGmxbjDBd5NigQ>? NVXCVnRyOi53L{WvNVAh|ryP MVSwMVQhcA>? M{e5folvcGmkaYTzJJRp\SCVVFHUN{Bi[3SrdnH0bY9vKGmwIHGg[I9{\S1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5mesLi NF\pSHAzPTJ4MUO2OS=>
PC3M-1E8 MnjVSpVv[3Srb36gRZN{[Xl? NEntNnMyOCEQvF2= NWrEUGt{OjRiaB?= NF7iW5hld3ewcnXneYxifGW|IFLjcE15VCxic4Xyeol3cW5iYX7kJIMuVXml M4LncVI2OjZzM{[1
PC3M-1E8 MYnGeY5kfGmxbjDBd5NigQ>? MXSxNEDPxE1? MYWyOEBp MX7pcohq[mm2czDJUE03KGmwZIXj[YQhW1SDVEOgZYN1cX[jdHnvckBidmRidHjlJGlNNTZvaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9v NE\PVGEzPTJ4MUO2OS=>
PC3M-1E8 M4XiNmNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= Mm\2Nk42NzVxMUCg{txO M{fYd4lvcGmkaYTzxsB1cGViY3;sc456KG[xcn3heIlwdiC|aXfubYZq[2GwdHz5 NGLJbo8zPTJ4MUO2OS=>
MDA-MB-231 MUfGeY5kfGmxbjDBd5NigQ>? MX:yNEDPxE1? Ml;YNkBp MVTlfIhq[mm2czDTcoFqdCCjbnSgSU1k[WSqZYLpckBmgHC{ZYPzbY9v MXGyOVE2OzN2OR?=
H9c2 NIXFNlZHfW6ldHnvckBCe3OjeR?= MXeyNEDDvU1? NGOyWI4{OCCvaX6= M1OyOWROW00EoB?= NU\YTpBN[WKxbHnzbIV{KHC{b4Dv[o9tNWmwZIXj[YQhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDic5RpKHOnckS3N{BidmRidHjyN|A5 NU\YTGZwOjVzMEWwOlc>
HaCaT  NVnZR|BQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUewNGEzOTBiwsXN M1HRdlIxKG2rbh?= MYLEUXNQyqB? NIW4PG5mdmijbnPld{B{d3KjZnXubYIuKGGwZDDzeY5qfGmwaXKtbY5lfWOnZDDndo94fGhiaX7obYJqfGmxbh?= M1P5fFI2ODF|OUC3
Caki-1 NVXSZpJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnib5UyOCEEtV2= MlfmNlAhdWmw MoDqSG1UV8Li NX3CXW44\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= NWLMTGhHOjVyMUO5NFc>
HaCaT  M{XRbWFxd3C2b4Ppd{BCe3OjeR?= MVixNEDDvU1? MUKyNEBucW5? Mn\SSG1UV8Li M2nXfIlv[3KnYYPld{Bxem:yb4L0bY9veyCxZjDhdI9xfG:2aXOgZ4VtdHNiZIXlJJRwKHS{ZXH0cYVvfCC5aYToJJNwemGoZX7pZkBweiC|dX7peIlvcWJ? MVqyOVAyOzlyNx?=
FHL-primed hNSCs MUTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M3LLfFAvODJvNTFOwG0> M2D5UlczKGh? MWHs[YFleyC2bzD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDheEBpcWeqIHPvcoNmdnS{YYTpc44> NHmwTVMzPDl2NUSzOC=>
ELL-primed hNSCs NXjhW3NtS2WubDDWbYFjcWyrdImgRZN{[Xl? MXmwMlAzNTVizszN NH\pWVA4OiCq NGW2e3dt\WGmczD0c{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBifCCqaXfoJINwdmOnboTyZZRqd25? MlXDNlQ6PDV2M{S=
SS Mn7KR4VtdCCYaXHibYxqfHliQYPzZZk> NFHRNnUyNTFyIN88US=> M3XUblczKGh? MXfEUXNQ NVnpPWZv[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> MnTVNlQ4PTZzMUG=
SeAx  MYHD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M3TRcFEuOTBizszN NEXnWHI4OiCq M1;LR2ROW09? MkHKZ4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= MX6yOFc2PjFzMR?=
HuT-78 M4HkN2NmdGxiVnnhZoltcXS7IFHzd4F6 NYHZT3hYOS1zMDFOwG0> M1XGe|czKGh? NVLoTpM3TE2VTx?= MXvjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= MmDDNlQ4PTZzMUG=
CD4+ MkLLRZBweHSxc3nzJGF{e2G7 MlfrNVDjiIoQvH2= MVeyOEBp MY\EUXNQ NWTDcYJscW6mdXPld{BieG:ydH;zbZMhe3S{b37ncJk> NGTGeFYzPDd3NkGxNS=>
MCF-7 M{TlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTlSXdGOC52NkmtN{44PSEQvF2= MlX4OUBl MknKdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 NHP2[pUzPDd{OEC3PC=>
MCF-7/LCC1 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rGVVAvPDZ7LUOuO|Uh|ryP NX7pbIY{PSCm M1qwc5Jm\HWlZYOgZ4VtdCCwdX3i[ZIhe2mpbnnmbYNidnSueR?= MX[yOFczQDB5OB?=
MCF-7/LCC9 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rvb|AvPDZ7LUOuO|Uh|ryP MYC1JIQ> MYXy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? NILINYozPDd{OEC3PC=>
HaCaT NVjudI5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPEeZJ3OTBiwsXN NYfBZnJkOjBibXnu MX7EUXNQyqB? M2qyRoVvcGGwY3XzJIV3\XKxbHnteZMucW6mdXPl[EBk\WyuIHfyc5d1cCCrbnjpZol1cW:w NWqwcZlIOjR2MkOxN|E>
HaCaT Mk\MRZBweHSxc3nzJGF{e2G7 NIrSSmoyOCEEtV2= M3fSZ|IxKG2rbh?= MUHEUXNQyqB? MmS1[Y5p[W6lZYOgeIhmKGGyb4D0c5Rq[yCnZn\lZ5R{KG:oIHX2[ZJwdGmvdYO= M{TCU|I1PDJ|MUOx
MDA-MB-231 MV3GeY5kfGmxbjDBd5NigQ>? MkfkNVAhyrWP NIXR[5kzPCCq NGC1TGhFVVORwrC= NH\hVXVz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> NWP5emJ[OjR|N{[1PFY>
SUM-159 NYnLRVhmTnWwY4Tpc44hSXO|YYm= MWmxNEDDvU1? Mm\nNlQhcA>? NGKzUnFFVVORwrC= MVHy[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= NFHtS3gzPDN5NkW4Oi=>
SK-BR-3 NH7SXWlHfW6ldHnvckBCe3OjeR?= M1v2UFExKML3TR?= MlfVNlQhcA>? MlPVSG1UV8Li MUny[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= NV7UZ5ZoOjR|N{[1PFY>
MCF7-HER2 NETuOVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrRRlFrOC1zMDFOwG0> MleyOFghcA>? M{nnVGROW09? Ml3ZbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MXSyOFI6PzVyOB?=
MCF7-HER2 NFLUZmhHfW6ldHnvckBCe3OjeR?= NFzv[os2KM7:TR?= MoHBNlQhcA>? NXX4TXU3TE2VTx?= NG\nSm1lcW2rbnnzbIV{KFOxeD2yMEBQ[3RvNDygZY5lKHOudXeg[ZhxemW|c3nvci=> NHrkWoszPDJ7N{WwPC=>
MCF7-HER2 M1LrTGZ2dmO2aX;uJGF{e2G7 MlXBOUDPxE1? Mo\BNlQhcA>? M2Lob2ROW09? NXzrTIxT\GWlcnXhd4V{KHSqZTDlfJBz\XO|aX;uJIxmfmWuczDv[kBGVVRibXHyb4Vzeyxidnnt[Y51cW5iYX7kJJNtfWd? NUL0ZZpJOjR{OUe1NFg>
MCF7-HER2 M4e3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jQNVUh|ryP NVvCT2NzOjRiaB?= NU\jWYlLTE2VTx?= M2\kOoVvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iY3;tZolv\WRid3n0bEBJ\XKlZYD0bY4> MViyOFI6PzVyOB?=
HMECs  MVLGeY5kfGmxbjDBd5NigQ>? NWrHOVFkOTBizszN MWGyJIg> M{LOfolvcGmkaYTzJGlHVs7zwrDt[YRq[XSnZDDwbI9{eGixconsZZRqd25ib3[gV3RCXDFuIGPURXQzKGGwZDDTWGFVOw>? M{nHd|I1OjFzM{K3
HTR8/SVneo NWDzfodoTnWwY4Tpc44hSXO|YYm= NUHCPVdtOcLizszNxsA> NEflWpAyyqCq NVHH[Hcxe3WycILld5Nm\CCRU12tbY5lfWOnZDDTWGFVOyCyaH;zdIhwenmuYYTpc44> NHvmTWYzPDB4MEK0NS=>
HTR8/SVneo NXTwfpBFTnWwY4Tpc44hSXO|YYm= NVXEVZU3OC53L{JCpO69VcLi M4rO[|Q5KGh? MVjy[ZN1d3KnczD0bIUh\XiycnXzd4lwdiCxZjDFMYNi\GincnnuJJN2eHC{ZYPz[YQh[nliT2PN NUDKcVZxOjRyNkCyOFE>
HTR8/SVneo NGHDSJhHfW6ldHnvckBCe3OjeR?= NUO3OWNzOcLizszNxsA> NVzXcHVQPDhiaB?= NEXTTXR{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczDtbYdz[XSrb36gZpkhV1OPwrC= MUCyOFA3ODJ2MR?=
C13* M{PrSmFxd3C2b4Ppd{BCe3OjeR?= NXXReIpLOC1zMDFOwG0> MlrlNlQwPDhiaB?= M{LSRolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy M{Xtd|I{QTZ{NUW4
OV2008 NHTBWIFCeG:ydH;zbZMhSXO|YYm= NF3LWoUxNTFyIN88US=> NXG3OpFHOjRxNEigbC=> MkH1bY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= M1nESFI{QTZ{NUW4
C13* MmHvRZBweHSxc3nzJGF{e2G7 NYHQfpA4OjRxNEigbC=> M1TjOYVvcGGwY3XzJINqe3CuYYTpck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NEGzSoQzOzl4MkW1PC=>
OV2008 MnjXRZBweHSxc3nzJGF{e2G7 NWnWVYJ[OjRxNEigbC=> M2PJZoVvcGGwY3XzJINqe3CuYYTpck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NGDFNIwzOzl4MkW1PC=>
W480  M1XzXGZ2dmO2aX;uJGF{e2G7 NIXCZ5YzNjVxMUCg{txO MoHxN|AhdWmw MVvEUXNQ NXLzPFFwe2Wwc3n0bZpmeyClZXzsd{B1dyClaHXtc5Ji\GmxdHjldoFxgSCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MX6yN|k{PDl5Mh?=
SW837 MnzKSpVv[3Srb36gRZN{[Xl? M4fUfFIvPS9zMDFOwG0> NUXQXJFuOzBibXnu MkXOSG1UVw>? M2fhcZNmdnOrdHn6[ZMh[2WubIOgeI8h[2inbX;yZYRqd3SqZYLhdJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MYqyN|k{PDl5Mh?=
T24 MYnGeY5kfGmxbjDBd5NigQ>? NX;Q[IkzOi9zMD:yNEDPxE1? MnH6NlQhcA>? MXzjZZV{\XNiZH;z[U1l\XCnbnTlcpQhcW6qaXLpeIlwdiCxZjD0bIUhS1iFTEGyMYlv\HWlZXSgbY5kemWjc3Wgc4YhcW64YXTpcoch[2WubIO= MV2yN|UzPjB5OR?=
CNE1 MmfjSpVv[3Srb36gRZN{[Xl? MoHRNlAhyrWP NHTtbZA1QCCq NYS2U|Q4[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NVHmOGFsOjN|OEK5NVQ>
CNE2 NG\r[INHfW6ldHnvckBCe3OjeR?= MYSyNEDDvU1? NE\nblg1QCCq NWfrWpNr[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NGDkVWYzOzN6MkmxOC=>
HONE1 NYTDUYFtTnWwY4Tpc44hSXO|YYm= M3fHPFIxKML3TR?= MXe0PEBp MVLicI9kc3NidHjlJGlNNTZiaX7jdoVie2WmIIDoc5NxcG:{eXzheIlwdiCxZjDTeIF1Ow>? NHixRpAzOzN6MkmxOC=>
CNE1 NGPONm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;pOEDPxE1? M3L1UJNq\26rZnnjZY51dHlicnXkeYNmeyClZXzsJJZq[WKrbHn0fS=> NGfFdmgzOzN6MkmxOC=>
CNE1 MXLGeY5kfGmxbjDBd5NigQ>? MlraNE0zOCEQvF2= NUfvPJhlOC12IHi= MnXmbY5pcWKrdIOgV5RifDNiYXP0bZZifGmxbjDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NUfRcZd6OjN|OEK5NVQ>
CNE2 NH3sOHhHfW6ldHnvckBCe3OjeR?= NYH1bGlYOC1{MDFOwG0> NXnMc2syOC12IHi= NHXQdmtqdmirYnn0d{BUfGG2MzDhZ5RqfmG2aX;uJIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> Mm\lNlM{QDJ7MUS=
HONE1 NIewUoVHfW6ldHnvckBCe3OjeR?= MX[wMVIxKM7:TR?= NVjNeo5jOC12IHi= MXjpcohq[mm2czDTeIF1OyCjY4TpeoF1cW:wIHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NX\2eIR5OjN|OEK5NVQ>
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C666-1  NIK2XpFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? Ml;sNE42NTZ2IN88US=> MW[0PEBp M4nGcJN2eHC{ZYPz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy MUGyN|M5OjlzNB?=
CNE1 MVTBdI9xfG:|aYOgRZN{[Xl? M17XeVExKML3TdMg NUXaR4g2PDhiaB?= M2XQXIlv\HWlZYOgZZBweHSxc3nzxsA> NHL2XmczOzN6MkmxOC=>
CNE2 NF[2W5VCeG:ydH;zbZMhSXO|YYm= MlzuNVAhyrWPwrC= M4PtdlQ5KGh? MYfpcoR2[2W|IHHwc5B1d3Orc9Mg Mmr4NlM{QDJ7MUS=
HONE1 MmfVRZBweHSxc3nzJGF{e2G7 MoDRNVAhyrWPwrC= MnriOFghcA>? NFn5S3RqdmS3Y3XzJIFxd3C2b4Ppd:Kh MVOyN|M5OjlzNB?=
CNE2 NELReGVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NFrCTooyNzJizszN NYDZSJRtPDhiaB?= MkPxd4Vve2m2aYrlJINmdGy|IITvJJJi\GmxdHjldoFxgQ>? M{LKOVI{Ozh{OUG0
HONE1 M1H1bWNmdGxiVnnhZoltcXS7IFHzd4F6 MnjzNU8zKM7:TR?= M13IfFQ5KGh? NIP6eVR{\W6|aYTpfoUh[2WubIOgeI8hemGmaX;0bIVz[XC7 MVeyN|M5OjlzNB?=
C666-1  MXTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MmKwNU8zKM7:TR?= M2mxZVQ5KGh? NIXNZW9{\W6|aYTpfoUh[2WubIOgeI8hemGmaX;0bIVz[XC7 MkGxNlM{QDJ7MUS=
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RL95-2 NU\NW2xyTnWwY4Tpc44hSXO|YYm= M33FR|HDqM7:TdMg M4\ENlI1KGh? NYHXWIo2TE2VTx?= MVTicI9kc3NidHjlJG1WSzJyLXXubIFv[2WmIHnueoF{cW:wIITybYdo\XKnZDDifUAyOCViRlLT NYTkblZNOjN{NkKyNFg>
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RL95-2 NG\XWJlHfW6ldHnvckBCe3OjeR?= NYq0VYxyOcLizszNxsA> M{X0bFI1KGh? M2LCN2ROW09? NWLCTZhF[myxY3vzJJRp\SCPVVOyNE1mdmijbnPl[EBqdn[jc3nvckB1emmpZ3Xy[YQh[nliRVfGxsA> M2\j[FI{OjZ{MkC4
CT26 M3i3[2Z2dmO2aX;uJGF{e2G7 MWWyNEBuVQ>? M13pe|EhcA>? NYXMfmdDe3WycILld5NmeyCKR1[tbY5lfWOnZDDWSWdHKGW6cILld5Nqd28EoB?= NGfWRnYzOzJ|M{G2Ny=>
UM-SCC-17B NVT5SJFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGniPHFKSzVyPUKuOVYzKMLzIECuOFA6KM7:TTygS2k2OD1zLkK3PUDDuSByLkG5OEDPxE1? NIDFT5AzOjd5MEi5PS=>
OSC-19 M1:2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTNwNEixJOKyKDBwOUWzJO69VSxiR1m1NF0yNjN4NjFCtUAxNjd5MDFOwG0> NV;iem43OjJ5N{C4PVk>
Cal33 NWXjbGs1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLkdpVMUUN3ME2yMlI5OiEEsTCwMlQzOyEQvF2sJGdKPTB;MT6zOFkhyrFiMD6zOlMh|ryP NVvTc2JCOjJ5N{C4PVk>
UM-SCC-22B MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;P[|VKSzVyPUKuOlQ5KMLzIECuOVQzKM7:TTygS2k2OD1zLkOyNEDDuSByLkKwOEDPxE1? MY[yNlc4ODh7OR?=
UM-SCC-17B MWDGeY5kfGmxbjDBd5NigQ>? M3PiV|AuOzBizszN MVGwMVI1KGh? M1nIO4lvcGmkaYTzJHNVSVR|IHHjeIl3[XSrb36g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= M4DNOFIzPzdyOEm5
OSC-19 MYHGeY5kfGmxbjDBd5NigQ>? NEPpZ5UxNTNyIN88US=> MXewMVI1KGh? MlvSbY5pcWKrdIOgV3RCXDNiYXP0bZZifGmxbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfGy7 Mny0NlI4PzB6OUm=
Cal33 M4DJZWZ2dmO2aX;uJGF{e2G7 MUSwMVMxKM7:TR?= MmjaNE0zPCCq NV;6elM{cW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 M2LCN|IzPzdyOEm5
UM-SCC-22B M{X0fGZ2dmO2aX;uJGF{e2G7 MmW4NE0{OCEQvF2= NYPSbYNJOC1{NDDo M37MeolvcGmkaYTzJHNVSVR|IHHjeIl3[XSrb36g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= NGezTFczOjd5MEi5PS=>
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U-373MG M2\2NmNmdGxiVnnhZoltcXS7IFHzd4F6 M2HBZlAuOTBizszN M2Hrc|czKGh? NYS0S5ZKTE2VTx?= NU\MepFicW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MYCyOVQ{PjZ6Mh?=
SH-SY5Y MoLIR4VtdCCYaXHibYxqfHliQYPzZZk> M3[zd|AuOTBizszN NFXkOGs4OiCq NXXQSo5RTE2VTx?= MYjpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 NVn4O4g2OjV2M{[2PFI>
Tu-9648 MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2ru[FAuOTBizszN NX3JXnlSPzJiaB?= NFXkXHpFVVOR NEHmTW1qdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 NUjwbHM2OjV2M{[2PFI>
Neuro-2a M3XyUmNmdGxiVnnhZoltcXS7IFHzd4F6 NW\hOIdZOC1zMDFOwG0> MlvyO|IhcA>? M1jufmROW09? MmXobY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? NITz[GozPTR|Nk[4Ni=>
PCNs MVPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MVGwMVExKM7:TR?= NU\TXHVwPzJiaB?= NIXzb29FVVOR NWOzN|FIcW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MX:yOVQ{PjZ6Mh?=
PGCs NX\Nd3J5S2WubDDWbYFjcWyrdImgRZN{[Xl? NXLsSYp6OC1zMDFOwG0> NGrpTFc4OiCq M13hN2ROW09? NGXkbo9qdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 Mk[3NlU1OzZ4OEK=
RAW264.7 NF60Tm5HfW6ldHnvckBCe3OjeR?= NVnoUpZEOTBizszN Mmj5NVIhcA>? NX\scII1[WK{b3fheIV{KHSqZTDtVm5CKGW6cILld5Nqd26|IH;mJGpCUzJuIGPURXQyNCCVVFHUNkwh[W6mIGPURXQ{KGmwZIXj[YQh[nliRF;OJIFv\CCWLUKgeI95cW5? MmXPNlI1PTR2M{G=
RAW264.7 NXy3eYJXSXCxcITvd4l{KEG|c3H5 M2DOdVUwOTBizszN MX[0OUBucW5? Mnfq[Y5p[W6lZYOgeI95cW6|IHnu[JVk\WRiYYDvdJRwe2m|IHHu[EBOVVBibH;zdy=> MoX2NlI1PTR2M{G=
SW480 MYDD[YxtKF[rYXLpcIl1gSCDc4PhfS=> Mlm4OU8yOC9{MDFOwG0> MkPiO|IhcA>? NEfE[VJqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDv[kB1cGViQVzETEswS0RzM{OrxsBk\Wyucx?= M{KxPVIyQTByM{m3
HCT116 NXrQNlByS2WubDDWbYFjcWyrdImgRZN{[Xl? NXPLS|dWPS9zMD:yNEDPxE1? NFzaWnU4OiCq NV3JcpI3cW6qaXLpeJMh[2WubDD2bYFjcWyrdImgc4YhfGinIFHMSGgsN0OGMUOzL:Kh[2WubIO= MoHiNlE6ODB|OUe=
DLD-1  NUDweXVPS2WubDDWbYFjcWyrdImgRZN{[Xl? NEfPT2U2NzFyL{KwJO69VQ>? MXe3NkBp M4DvT4lvcGmkaYTzJINmdGxidnnhZoltcXS7IH;mJJRp\SCDTFTIL{9ETDF|MzxCpINmdGy| MmfmNlE6ODB|OUe=
SNU387  M4\DdWNmdGxiVnnhZoltcXS7IFHzd4F6 MVOyNOKh|ryPwrC= NGrwNHozPCCq NIrkOpNz\WS3Y3XzJINmdGxidnnhZoltcXS7 NVXUbXZ2OjF|MUG5O|U>
SNU398 MVfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NE[2dVgzOMLizszNxsA> NWDCR|dXOjRiaB?= MVHy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 MUiyNVMyOTl5NR?=
HepG2 NXTaXWZwS2WubDDWbYFjcWyrdImgRZN{[Xl? Mn\GNlDDqM7:TdMg NFfKPGszPCCq NV\aPWhMemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= MkGxNlE{OTF7N{W=
Huh-7 M4n3dmNmdGxiVnnhZoltcXS7IFHzd4F6 M3fOXFIxyqEQvF5CpC=> MlHlNlQhcA>? MlXBdoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? M4P5bFIyOzFzOUe1
VSMC NUHtR|RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXtd2piOy93L{GwJO69VQ>? M4r2VVMxKG2rbh?= NVLQbWtJTE2VTx?= M3qzW5Bz\X[nboTzJHBFT0ZvIHHu[EB1cHKxbXLpck1u\WSrYYTl[EBXW02FIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NWX1XXM2OjB6NEezNFY>
MDA-MB-231 MX3BdI9xfG:|aYOgRZN{[Xl? MljqNVAh|ryP NVn5R4ZNOjRiaB?= NWjOZmdOTE2VT9Mg MkHGbY5lfWOnczDhdI9xfG:|aYO= MWOxO|EyPDByNR?=
MDA-MB-435S M{X0bWFxd3C2b4Ppd{BCe3OjeR?= M2rhfVExKM7:TR?= MW[yOEBp NFnlR2JFVVORwrC= NHXue3pqdmS3Y3XzJIFxd3C2b4Ppdy=> NVvEeppROTdzMUSwNFU>

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+H2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID