Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

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Cited by 27 Publications

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MYLGeY5kfGmxbjDBd5NigQ>? MkLhNVDjiIoQvF2= M3\yUVTjiImq NHXhU4Fz\X[ncoPld{B1cGViZX\m[YN1eyCxZjDJUE0zPw>? Mm\QNlY{Ozl4M{O=
NPC  NX3QcnBPTnWwY4Tpc44hSXO|YYm= MnnnNE04NjViwsXN Mk\tZYJwdGm|aHXzJGVOXC2uaXvlJI1wdGWldXzhdkBidHSncnH0bY9veyxiYX7kJINmdGxibXnndoF1cW:wIHHu[EBqdn[jc3nvckBqdmS3Y3XkJIJ6KFKNSWCgb45w[2umb4fu MmL1NlU6OTV2M{C=
HASMC MonPSpVv[3Srb36gRZN{[Xl? NWHnfJdKOS5{NT21JO69VQ>? M3;KW|IxKG2rbh?= MoexSG1UV8Li MVjpcohq[mm2czDwMUh[MS2VVFHUMVEtOyx3IIPp[45idHQEoB?= MXmyOVg1QTZ{Mh?=
H9c2  MX7GeY5kfGmxbjDBd5NigQ>? NFHrbJAzNzFyIN88US=> NXzsU|IzOiCq NEXRSohFVVORwrC= NUK3flFP[WK{b3fheIV{yqC2aHWgZ5l1d3C{b4TlZ5RqfmViZX\m[YN1eyCxZjDJUE0zPyCjZ3HpcpN1KFOK M3OwW|I2QDJyOUC3
A431 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fkUVLDqM7:TR?= NYrXRoZjOsLiaB?= NVvONWF7[myxY3vzJGVITi2{ZY\ldpNm\CCmZXPy[YF{\XNiaX6gZ4VtdCC4aXHibYxqfHl? MYmyOVczODR|NR?=
A431 NF3Cd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP5NuKh|ryP NEnwXW0zyqCq M3TwWIlv[3KnYYPld{BqdiCjcH;weI9{cXNiaX7keYNm\CCkeTDzbIlsd26rbh?= NXj5V3lqOjV5MkC0N|U>
SiHa NGrBV4ZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYPt[mdtPS15NTDuUS=> MVOyOOKhcMLi M1i4NJNpd3e|IH3vdpBpd2yxZ4mgc4Yh[SC2eYDpZ4FtKGGyb4D0c5Rq[yClZXzsJIFv\CCmb4PlMYRmeGWwZHXueEBtd3O|IH;mJINmdGxidnnhZoltcXS7wrC= MYiyOVU{QTZ2NB?=
SiHa NVf1WlJITnWwY4Tpc44hSXO|YYm= M1;QdVUuPzVibl2= MYSyOOKhcMLi M2HHfZJm\HWlZYOgeIhmyqCyaH;zdIhwenmuYYTpc44h[XRidHjlJJR6em:|aX7lJJJme2mmdXWgO|A2yqB? M{m0SlI2PTN7NkS0
ECA109 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDUfplbOC1{MDFOwG0> MWGyOOKhcMLi NWPGXZBJUUN3ME21MlUxKM7:TR?= MmDBNlU1QTJ2OEC=
TE13 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\nTFAxNTJyIN88US=> MVWyOOKhcMLi MkP0TWM2OD14LkG1xsDPxE1? NUHTb2w3OjV2OUK0PFA>
KYSE150  NX;QXVVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jFb|AuOjBizszN MlzTNlTDqGkEoB?= MV;JR|UxRTF{Lk[0xsDPxE1? NIXscJkzPTR7MkS4NC=>
ECA109 NIrzWHhEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 M4jZZVAvPcLizszN MViyOOKhcMLi Ml;vd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= Mkm5NlU1QTJ2OEC=
TE13 M4rhXGNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= Ml7TNE42yqEQvF2= MkX5NlTDqGkEoB?= NG\ad21{fXCycnXzd4V{KHSqZTDjcI9vd2enbnnjJIZwem2jdHnvci=> MmPBNlU1QTJ2OEC=
KYSE150  MYLDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 NIKyWIkxNjYEoN88US=> MoCyNlTDqGkEoB?= MkPQd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= MYKyOVQ6OjR6MB?=
ECA109 NUX0ZYlFTnWwY4Tpc44hSXO|YYm= MYiwMlXDqM7:TR?= NILmfJYzPMLiaNMg NEjFZYVmdmijbnPld{BKWi2rbnT1Z4VlKGenbnXyZZRqd25ib3[gSHNDew>? M3PsR|I2PDl{NEiw
PC3M-1E8 M3;FOWZ2dmO2aX;uJGF{e2G7 MWKyMlUwPS9zMDFOwG0> M1HoNVAuPCCq NFnDXohqdmirYnn0d{B1cGViU2TBWFMh[WO2aY\heIlwdiCrbjDhJIRwe2VvIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XMEoB?= NYXZUnU2OjV{NkGzOlU>
PC3M-1E8 NGnGXm5HfW6ldHnvckBCe3OjeR?= NXy3dJIyOTBizszN MlvuNlQhcA>? NX;Le|RE\G:5boLl[5Vt[XSnczDCZ4wugExuIIP1dpZqfmmwIHHu[EBkNU27Yx?= MkK5NlUzPjF|NkW=
PC3M-1E8 NFL4fWRHfW6ldHnvckBCe3OjeR?= MXSxNEDPxE1? NWLMVoN7OjRiaB?= MVTpcohq[mm2czDJUE03KGmwZIXj[YQhW1SDVEOgZYN1cX[jdHnvckBidmRidHjlJGlNNTZvaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9v NUO2e5hKOjV{NkGzOlU>
PC3M-1E8 NWqzdolwS2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> NGL5cIQzNjVxNT:xNEDPxE1? MWnpcohq[mm2c9MgeIhmKGOxbH;ufUBnd3KvYYTpc44he2mpbnnmbYNidnSueR?= NHjId4MzPTJ4MUO2OS=>
MDA-MB-231 M3W2cWZ2dmO2aX;uJGF{e2G7 NGrpWnczOCEQvF2= MXOyJIg> NXvVNIZn\XiqaXLpeJMhW26jaXygZY5lKEVvY3HkbIVzcW5iZYjwdoV{e2mxbh?= MXSyOVE2OzN2OR?=
H9c2 M1rSRWZ2dmO2aX;uJGF{e2G7 MmnzNlAhyrWP MmHHN|AhdWmw NFyxO2lFVVORwrC= MkHNZYJwdGm|aHXzJJBzd3CxZn;sMYlv\HWlZXSgRWtVKHCqb4PwbI9zgWyjdHnvckBifCCkb4ToJJNmejR5MzDhcoQhfGi{M{C4 NV3ETmVQOjVzMEWwOlc>
HaCaT  NYf6SIRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i2RlExKML3TR?= M{GwSVIxKG2rbh?= M{nuW2ROW00EoB?= M1L3N4VvcGGwY3XzJJNwemGoZX7pZk0h[W6mIIP1col1cW6rYj3pcoR2[2WmIHfyc5d1cCCrbnjpZol1cW:w NXX3[pZpOjVyMUO5NFc>
Caki-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\1blhpOTBiwsXN MojkNlAhdWmw MUnEUXNQyqB? M2H1N4VvcGGwY3XzJJNwemGoZX7pZk0h[W6mIIP1col1cW6rYj3pcoR2[2WmIHfyc5d1cCCrbnjpZol1cW:w NGLlSFMzPTBzM{mwOy=>
HaCaT  NXfDcJZJSXCxcITvd4l{KEG|c3H5 NFHIb|YyOCEEtV2= NYLs[IN1OjBibXnu MYPEUXNQyqB? NEfQdGZqdmO{ZXHz[ZMheHKxcH;yeIlwdnNib3[gZZBweHSxdHnjJINmdGy|IHT1[UB1dyC2cnXheI1mdnRid3n0bEB{d3KjZnXubYIhd3Jic4XubZRqdmmk M{L1WVI2ODF|OUC3
FHL-primed hNSCs M2nSVWNmdGxiVnnhZoltcXS7IFHzd4F6 NGj4V5IxNjB{LUWg{txO M33XcVczKGh? M4K5e4xm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? NHzhbmYzPDl2NUSzOC=>
ELL-primed hNSCs MnHRR4VtdCCYaXHibYxqfHliQYPzZZk> MY[wMlAzNTVizszN M2KxclczKGh? M1vKVIxm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? MWGyOFk1PTR|NB?=
SS MXvD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NHfGU3MyNTFyIN88US=> NGLZfGM4OiCq MXPEUXNQ NHTzfm5k[XW|ZYOgZUBld3OnLXTldIVv\GWwdDDpcohq[mm2aX;uJI9nKHSqZTD2bYFjcWyrdIpCpC=> NFjhW2czPDd3NkGxNS=>
SeAx  NVzOOGlKS2WubDDWbYFjcWyrdImgRZN{[Xl? MUmxMVExKM7:TR?= NFnjWZc4OiCq Ml3xSG1UVw>? NYnMdmtS[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> M{PL[FI1PzV4MUGx
HuT-78 MlT0R4VtdCCYaXHibYxqfHliQYPzZZk> NUDQS3A1OS1zMDFOwG0> NH\qPGo4OiCq MmnRSG1UVw>? MWDjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= Mm\WNlQ4PTZzMUG=
CD4+ MmTRRZBweHSxc3nzJGF{e2G7 M3\UVFEx6oDLzszt MnjFNlQhcA>? MmX1SG1UVw>? NIjkeldqdmS3Y3XzJIFxd3C2b4Ppd{B{fHKxbnfsfS=> MWSyOFc2PjFzMR?=
MCF-7 M{PtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVGwMlQ3QS1|Lke1JO69VQ>? M1HvRlUh\A>? NEPSPVdz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= MoDhNlQ4OjhyN{i=
MCF-7/LCC1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDUV4YxNjR4OT2zMlc2KM7:TR?= MkjLOUBl M3q1WJJm\HWlZYOgZ4VtdCCwdX3i[ZIhe2mpbnnmbYNidnSueR?= MoHlNlQ4OjhyN{i=
MCF-7/LCC9 M4HYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jFelAvPDZ7LUOuO|Uh|ryP NGryVYs2KGR? MWXy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? NWexUlZ6OjR5MkiwO|g>
HaCaT NFO2TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHNfWJpOTBiwsXN MVOyNEBucW5? MXrEUXNQyqB? MUHlcohidmOnczDleoVzd2yrbYXzMYlv\HWlZXSgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdg>? MU[yOFQzOzF|MR?=
HaCaT MnvGRZBweHSxc3nzJGF{e2G7 MkDhNVAhyrWP MYqyNEBucW5? MonRSG1UV8Li MXHlcohidmOnczD0bIUh[XCxcITveIlkKGWoZnXjeJMhd2ZiZY\ldo9tcW23cx?= MXSyOFQzOzF|MR?=
MDA-MB-231 M3LuXGZ2dmO2aX;uJGF{e2G7 NEHj[YoyOCEEtV2= NVTHTmp6OjRiaB?= MX3EUXNQyqB? MkDXdoVlfWOnczDQMXNVSVR|IHX4dJJme3Orb36= M3f3NlI1Ozd4NUi2
SUM-159 NXX3UHFLTnWwY4Tpc44hSXO|YYm= NVvKdYpZOTBiwsXN MYSyOEBp MnO0SG1UV8Li NVG2SYEzemWmdXPld{BRNVOWQWSzJIV5eHKnc4Ppc44> MVuyOFM4PjV6Nh?=
SK-BR-3 MlLaSpVv[3Srb36gRZN{[Xl? M3TGXlExKML3TR?= NHnGbYIzPCCq NHfVSnRFVVORwrC= MoDIdoVlfWOnczDQMXNVSVR|IHX4dJJme3Orb36= Mle3NlQ{PzZ3OE[=
MCF7-HER2 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHaNE0yOCEQvF2= NHTMXHg1QCCq MnHVSG1UVw>? MWnpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= NVS5SVZbOjR{OUe1NFg>
MCF7-HER2 M1jKfGZ2dmO2aX;uJGF{e2G7 NIjidGU2KM7:TR?= NYDjdHdoOjRiaB?= M{W0WGROW09? MVXkbY1qdmm|aHXzJHNwgC1{LDDPZ5QuPCxiYX7kJJNtfWdiZYjwdoV{e2mxbh?= NHy0UJMzPDJ7N{WwPC=>
MCF7-HER2 MmO1SpVv[3Srb36gRZN{[Xl? MVu1JO69VQ>? NY[wUG1vOjRiaB?= NIHzVGlFVVOR MorR[IVkemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVteyCxZjDFUXQhdWG{a3Xyd{whfmmvZX70bY4h[W6mIIPseYc> NHvCZm4zPDJ7N{WwPC=>
MCF7-HER2 M{fU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PlbVUh|ryP NYnaZVZ5OjRiaB?= M1LRV2ROW09? MkLo[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiClb33ibY5m\CC5aYToJGhmemOncITpci=> M{jBNVI1Ojl5NUC4
HMECs  NIXEbHpHfW6ldHnvckBCe3OjeR?= M1yzN|ExKM7:TR?= NUHoeJVyOiCq MVnpcohq[mm2czDJSm7PucLibXXkbYF1\WRicHjvd5Bpd3K7bHH0bY9vKG:oIGPURXQyNCCVVFHUNkBidmRiU2TBWFM> NWLaOFdtOjR{MUGzNlc>
HTR8/SVneo MmnGSpVv[3Srb36gRZN{[Xl? NHrNdWgyyqEQvF5CpC=> MVOxxsBp NXHJV2d7e3WycILld5Nm\CCRU12tbY5lfWOnZDDTWGFVOyCyaH;zdIhwenmuYYTpc44> MYSyOFA3ODJ2MR?=
HTR8/SVneo NGjUW3VHfW6ldHnvckBCe3OjeR?= M1TJVFAvPS9zwrFOwG3DqA>? NGXuTlY1QCCq M{D5ZZJme3SxcnXzJJRp\SCneIDy[ZN{cW:wIH;mJGUu[2GmaHXybY4he3WycILld5Nm\CCkeTDPV20> NIjaU4MzPDB4MEK0NS=>
HTR8/SVneo MWrGeY5kfGmxbjDBd5NigQ>? NWrFe4NkOcLizszNxsA> NWLQV|RpPDhiaB?= MX3zbYdvcW[rY3HueIx6KGmwY4LlZZNmeyCvaXfyZZRqd25iYomgU3NOyqB? NWnrU2gxOjRyNkCyOFE>
C13* M3HKUGFxd3C2b4Ppd{BCe3OjeR?= NVzrRpJoOC1zMDFOwG0> NHvwSXAzPC92ODDo MoTsbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= Mmn6NlM6PjJ3NUi=
OV2008 NYK3NXB[SXCxcITvd4l{KEG|c3H5 NInOSVIxNTFyIN88US=> M2XQb|I1NzR6IHi= M2XjOolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy M1TkXlI{QTZ{NUW4
C13* MlPDRZBweHSxc3nzJGF{e2G7 NHPaW5czPC92ODDo M4XWZ4VvcGGwY3XzJINqe3CuYYTpck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NVfYVGI3OjN7NkK1OVg>
OV2008 MmnaRZBweHSxc3nzJGF{e2G7 NWqybINqOjRxNEigbC=> NGXnSZpmdmijbnPld{BkcXOybHH0bY4ucW6mdXPl[EBieG:ydH;zbZM> NELpe2szOzl4MkW1PC=>
W480  MnrVSpVv[3Srb36gRZN{[Xl? NEnWWHUzNjVxMUCg{txO MYCzNEBucW5? NGf6bVVFVVOR MnH3d4Vve2m2aYrld{Bk\WyuczD0c{BkcGWvb4Lh[IlwfGincnHwfUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M1u1PVI{QTN2OUey
SW837 MmTiSpVv[3Srb36gRZN{[Xl? NV7wTVJTOi53L{GwJO69VQ>? MnPVN|AhdWmw M1:5Z2ROW09? M1;PW5NmdnOrdHn6[ZMh[2WubIOgeI8h[2inbX;yZYRqd3SqZYLhdJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NYTnfYJsOjN7M{S5O|I>
T24 NFLndJNHfW6ldHnvckBCe3OjeR?= NVX2dohkOi9zMD:yNEDPxE1? MVWyOEBp M1q5[INifXOnczDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SCFWFPMNVIucW6mdXPl[EBqdmO{ZXHz[UBw\iCrbo\h[Ilv\yClZXzsdy=> MXOyN|UzPjB5OR?=
CNE1 M3LsT2Z2dmO2aX;uJGF{e2G7 M1jGWlIxKML3TR?= NFvyb4w1QCCq NGrnW2djdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= NXHEXWRxOjN|OEK5NVQ>
CNE2 NGG2cYhHfW6ldHnvckBCe3OjeR?= MYeyNEDDvU1? Ml3uOFghcA>? MUficI9kc3NidHjlJGlNNTZiaX7jdoVie2WmIIDoc5NxcG:{eXzheIlwdiCxZjDTeIF1Ow>? M3;4UlI{Ozh{OUG0
HONE1 MliySpVv[3Srb36gRZN{[Xl? Mly0NlAhyrWP NFjn[WE1QCCq M1PNVoJtd2OtczD0bIUhUUxvNjDpcoNz\WG|ZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJHN1[XR| MmLyNlM{QDJ7MUS=
CNE1 NE\ER4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWi0JO69VQ>? NITpZZd{cWewaX\pZ4FvfGy7IILl[JVk\XNiY3XscEB3cWGkaXzpeJk> NHjNTJQzOzN6MkmxOC=>
CNE1 MUPGeY5kfGmxbjDBd5NigQ>? MoG1NE0zOCEQvF2= NY\5eHNKOC12IHi= NYHIcY1QcW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> NVz4N4FxOjN|OEK5NVQ>
CNE2 NYjqWoxTTnWwY4Tpc44hSXO|YYm= MlTYNE0zOCEQvF2= M{TTcVAuPCCq NVru[5kzcW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> NV;pc2ZzOjN|OEK5NVQ>
HONE1 MnG5SpVv[3Srb36gRZN{[Xl? NX[yOZhxOC1{MDFOwG0> NWDq[pB2OC12IHi= NHTFUIdqdmirYnn0d{BUfGG2MzDhZ5RqfmG2aX;uJIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> M4rjU|I{Ozh{OUG0
CNE1 M1ziZWNmdGxiVnnhZoltcXS7IFHzd4F6 MVSwMlUuPjRizszN MoHROFghcA>? NE[2WHl{fXCycnXzd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> M4LMVVI{Ozh{OUG0
CNE2 MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MmXUNE42NTZ2IN88US=> NXS0b4o3PDhiaB?= NHrXWWJ{fXCycnXzd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> NHXTS2czOzN6MkmxOC=>
HONE1 NX\BNJpiS2WubDDWbYFjcWyrdImgRZN{[Xl? NWjsRo54OC53LU[0JO69VQ>? MmHHOFghcA>? NIn2cI1{fXCycnXzd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> M1Sx[lI{Ozh{OUG0
C666-1  MW\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MlHWNE42NTZ2IN88US=> MVy0PEBp NWrkN3A2e3WycILld5NmeyClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> MYiyN|M5OjlzNB?=
CNE1 MVjBdI9xfG:|aYOgRZN{[Xl? M4W3e|ExKML3TdMg MYK0PEBp MWrpcoR2[2W|IHHwc5B1d3Orc9Mg NEXCSZozOzN6MkmxOC=>
CNE2 MlmzRZBweHSxc3nzJGF{e2G7 MWGxNEDDvU4EoB?= Mn[yOFghcA>? MXvpcoR2[2W|IHHwc5B1d3Orc9Mg NHXMT4MzOzN6MkmxOC=>
HONE1 NXjaU|l4SXCxcITvd4l{KEG|c3H5 Mnu1NVAhyrWPwrC= NELzfGE1QCCq NGnGOllqdmS3Y3XzJIFxd3C2b4Ppd:Kh M{LwVVI{Ozh{OUG0
CNE2 M3H6e2NmdGxiVnnhZoltcXS7IFHzd4F6 M2rnSFEwOiEQvF2= MoPiOFghcA>? M{DiWJNmdnOrdHn6[UBk\WyuczD0c{Bz[WSrb4To[ZJieHl? NUX0NnlYOjN|OEK5NVQ>
HONE1 MYTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NUPtOWM1OS9{IN88US=> MUK0PEBp Mlfrd4Vve2m2aYrlJINmdGy|IITvJJJi\GmxdHjldoFxgQ>? MVKyN|M5OjlzNB?=
C666-1  MnXnR4VtdCCYaXHibYxqfHliQYPzZZk> NXizbo9NOS9{IN88US=> NF3EPW41QCCq MW\z[Y5{cXSrenWgZ4VtdHNidH:gdoFlcW:2aHXyZZB6 Mo\DNlM{QDJ7MUS=
HEC-1A MUPGeY5kfGmxbjDBd5NigQ>? M1y5cFHDqM7:TdMg Mn;ONlQhcA>? M1jXSGROW09? NYfqVFJ1[myxY3vzJJRp\SCPVVOyNE1mdmijbnPl[EBqdn[jc3nvckB1emmpZ3Xy[YQh[nliMUClJGZDWw>? NYTZPIRbOjN{NkKyNFg>
RL95-2 NFfsWGxHfW6ldHnvckBCe3OjeR?= MXSxxsDPxE4EoB?= NGfYeG4zPCCq MVvEUXNQ M33hT4Jtd2OtczD0bIUhVVWFMkCt[Y5p[W6lZXSgbY53[XOrb36geJJq\2encnXkJIJ6KDFyJTDGRnM> M4\sOVI{OjZ{MkC4
HEC-1A NEDuNIJHfW6ldHnvckBCe3OjeR?= NWTFd3NMOcLizszNxsA> Mk[4NlQhcA>? NGCxXJZFVVOR NHnPcoljdG:la4OgeIhmKE2XQ{KwMYVvcGGwY3XkJIlvfmG|aX;uJJRzcWepZYLl[EBjgSCHR1dCpC=> MYeyN|I3OjJyOB?=
RL95-2 MWHGeY5kfGmxbjDBd5NigQ>? NF;sUHgyyqEQvF5CpC=> Ml;qNlQhcA>? MnXoSG1UVw>? NH7mNnBjdG:la4OgeIhmKE2XQ{KwMYVvcGGwY3XkJIlvfmG|aX;uJJRzcWepZYLl[EBjgSCHR1dCpC=> NIf6ZmQzOzJ4MkKwPC=>
CT26 M{\KW2Z2dmO2aX;uJGF{e2G7 NIXuRogzOCCvTR?= MUSxJIg> MWnzeZBxemW|c3XzJGhITi2rbnT1Z4VlKF[HR1[g[ZhxemW|c3nvcuKh NYrKbVM{OjN{M{OxOlM>
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OSC-19 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDkTWM2OD1|LkS4NUDDuSByLkm1N{DPxE1uIFfJOVA:OS5|Nk[gxtEhOC55N{Cg{txO Mn72NlI4PzB6OUm=
Cal33 NF34O4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwMkiyJOKyKDBwNEKzJO69VSxiR1m1NF0yNjN2OTFCtUAxNjN4MzFOwG0> MmPJNlI4PzB6OUm=
UM-SCC-22B NXjVOI9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqw[nNKSzVyPUKuOlQ5KMLzIECuOVQzKM7:TTygS2k2OD1zLkOyNEDDuSByLkKwOEDPxE1? MUmyNlc4ODh7OR?=
UM-SCC-17B M1PwNWZ2dmO2aX;uJGF{e2G7 NWX2SnUyOC1|MDFOwG0> MlPrNE0zPCCq M1;1W4lvcGmkaYTzJHNVSVR|IHHjeIl3[XSrb36g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= M2jJXlIzPzdyOEm5
OSC-19 M4D4WGZ2dmO2aX;uJGF{e2G7 MmHVNE0{OCEQvF2= NIrXZo4xNTJ2IHi= NIfKN|FqdmirYnn0d{BUXEGWMzDhZ5RqfmG2aX;uJIRwe2ViYX7kJJRqdWViZHXw[Y5l\W62bIm= M{TnbVIzPzdyOEm5
Cal33 NFvWeXRHfW6ldHnvckBCe3OjeR?= NYXiOYRNOC1|MDFOwG0> Ml7BNE0zPCCq M2q4S4lvcGmkaYTzJHNVSVR|IHHjeIl3[XSrb36g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= NH;XV2czOjd5MEi5PS=>
UM-SCC-22B Ml3BSpVv[3Srb36gRZN{[Xl? MVqwMVMxKM7:TR?= M3\1W|AuOjRiaB?= MkHSbY5pcWKrdIOgV3RCXDNiYXP0bZZifGmxbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfGy7 NHP2fWkzOjd5MEi5PS=>
U-87MG MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGTnfpcxNTFyIN88US=> M3XqNFczKGh? MYTEUXNQ NWfqOWl2cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= NGm3b48zPTR|Nk[4Ni=>
U-373MG NX70SmlpS2WubDDWbYFjcWyrdImgRZN{[Xl? MoXtNE0yOCEQvF2= M3fjNFczKGh? M1Hv[GROW09? NGT1S29qdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 MUeyOVQ{PjZ6Mh?=
SH-SY5Y MYHD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1fCVVAuOTBizszN NFu0e3A4OiCq NXXDc2pKTE2VTx?= M1zlTIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? MWCyOVQ{PjZ6Mh?=
Tu-9648 M3vWRmNmdGxiVnnhZoltcXS7IFHzd4F6 MWKwMVExKM7:TR?= MYK3NkBp Ml\XSG1UVw>? NH7lfopqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 NGXnOZozPTR|Nk[4Ni=>
Neuro-2a NYn3e4FYS2WubDDWbYFjcWyrdImgRZN{[Xl? M4PCRlAuOTBizszN MnfEO|IhcA>? NGfj[3lFVVOR M3L6cIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NGTSc2EzPTR|Nk[4Ni=>
PCNs NUHrb41qS2WubDDWbYFjcWyrdImgRZN{[Xl? NYTITJdXOC1zMDFOwG0> MYi3NkBp MVzEUXNQ NHH3W|lqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 M{LNZVI2PDN4Nkiy
PGCs MX\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MVmwMVExKM7:TR?= MV63NkBp M4rNN2ROW09? MXLpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MYGyOVQ{PjZ6Mh?=
RAW264.7 MX7GeY5kfGmxbjDBd5NigQ>? NV3vc3ZQOTBizszN MonVNVIhcA>? MWnhZpJw\2G2ZYOgeIhmKG2UTlGg[ZhxemW|c3nvcpMhd2ZiSlHLNkwhW1SDVEGsJHNVSVR{LDDhcoQhW1SDVEOgbY5lfWOnZDDifUBFV05iYX7kJHQuOiC2b4jpci=> NXzhUWpEOjJ2NUS0N|E>
RAW264.7 MYnBdI9xfG:|aYOgRZN{[Xl? MkHtOU8yOCEQvF2= MYO0OUBucW5? MUXlcohidmOnczD0c5hqdnNiaX7keYNm\CCjcH;weI9{cXNiYX7kJG1OWCCub4Pz NFLnemEzOjR3NESzNS=>
SW480 NHe0e5lE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NFnKcIU2NzFyL{KwJO69VQ>? MlPKO|IhcA>? MUHpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCxZjD0bIUhSUyGSDuvR2QyOzNtwrDj[Yxtew>? M1q3TFIyQTByM{m3
HCT116 NHnWdpBE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NXvnbIhtPS9zMD:yNEDPxE1? NW\6T4dJPzJiaB?= NFHufnNqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDv[kB1cGViQVzETEswS0RzM{OrxsBk\Wyucx?= NYTwdpdjOjF7MECzPVc>
DLD-1  M1LJOGNmdGxiVnnhZoltcXS7IFHzd4F6 MlTJOU8yOC9{MDFOwG0> NUfCdW92PzJiaB?= MnXMbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? MofiNlE6ODB|OUe=
SNU387  NVjEbJRqS2WubDDWbYFjcWyrdImgRZN{[Xl? M4SyW|IxyqEQvF5CpC=> NXribGZnOjRiaB?= MU\y[YR2[2W|IHPlcIwhfmmjYnnsbZR6 M1q1XFIyOzFzOUe1
SNU398 MX3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M{C4N|IxyqEQvF5CpC=> MWmyOEBp NGKyU45z\WS3Y3XzJINmdGxidnnhZoltcXS7 MmK5NlE{OTF7N{W=
HepG2 M1TpPGNmdGxiVnnhZoltcXS7IFHzd4F6 NIexXFMzOMLizszNxsA> Mk\ENlQhcA>? NFv5TnBz\WS3Y3XzJINmdGxidnnhZoltcXS7 M3zPfFIyOzFzOUe1
Huh-7 M3z1[2NmdGxiVnnhZoltcXS7IFHzd4F6 MUCyNOKh|ryPwrC= Mo\INlQhcA>? NWD5W2NyemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= MYCyNVMyOTl5NR?=
VSMC MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[zM|UwOTBizszN MU[zNEBucW5? MnLHSG1UVw>? MlH6dJJmfmWwdIOgVGRITi1iYX7kJJRpem:vYnnuMY1m\GmjdHXkJHZUVUNicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> Mn;HNlA5PDd|ME[=
MDA-MB-231 NEfjXlJCeG:ydH;zbZMhSXO|YYm= NHzpNFMyOCEQvF2= MnqyNlQhcA>? MXnEUXNQyqB? M2DwbYlv\HWlZYOgZZBweHSxc3nz NU[3dWxIOTdzMUSwNFU>
MDA-MB-435S MV3BdI9xfG:|aYOgRZN{[Xl? MmPnNVAh|ryP M4X0O|I1KGh? NVizWHBETE2VT9Mg M4fZN4lv\HWlZYOgZZBweHSxc3nz Mne2NVcyOTRyMEW=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+H2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID