For research use only. Not for use in humans.
Catalog No.S7678 Synonyms: Sacubitril, Valsartan
Molecular Weight(MW): 915.98
Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
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Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (***P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (*P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (***P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (**P < 0.01, n = 7 per group).
J Mol Cell Cardiol, 2017, 108:138-148. Sacubitril/valsartan (LCZ696) purchased from Selleck.
Representative H&E stain of heart sections from (A) sham-operated group, (B) model group, (C) LCZ696-treated group. Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×100).
RSC Adv, 2017, doi:10.1039/C7RA01404J. Sacubitril/valsartan (LCZ696) purchased from Selleck.
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|Description||Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.|
|In vivo||In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity.  In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. |
|In vitro||Water||100 mg/mL warmed (109.17 mM)|
|DMSO||30 mg/mL warmed (32.75 mM)|
|Ethanol||9 mg/mL warmed (9.82 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02690974||Completed||Drug: LCZ696 (sacubitril/valsartan)||Hearth Failure With Reduced Ejection Fraction (HFrEF)||Novartis Pharmaceuticals|Novartis||March 8 2016||Phase 4|
|NCT02661217||Completed||Drug: LCZ696||Heart Failure With Reduced Ejection Fraction||Novartis Pharmaceuticals|Novartis||February 12 2016||Phase 4|
|NCT02226120||Completed||Drug: LCZ696||Chronic Heart Failure With Reduced Ejection Fraction||Novartis Pharmaceuticals|Novartis||October 16 2014||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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