Sacubitril/valsartan (LCZ696)
For research use only. Not for use in humans.
Catalog No.S7678 Synonyms: Sacubitril, Valsartan
2 publications
Molecular Weight(MW): 915.98
Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
Selleck's Sacubitril/valsartan (LCZ696) has been cited by 2 publications
2 Customer Reviews
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Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (***P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (*P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (***P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (**P < 0.01, n = 7 per group).
J Mol Cell Cardiol, 2017, 108:138-148. Sacubitril/valsartan (LCZ696) purchased from Selleck.
Representative H&E stain of heart sections from (A) sham-operated group, (B) model group, (C) LCZ696-treated group. Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×100).
RSC Adv, 2017, doi:10.1039/C7RA01404J. Sacubitril/valsartan (LCZ696) purchased from Selleck.
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Biological Activity
| Description | Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3. | ||||||
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| In vivo | In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. [1] In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. [2] |
Protocol
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Solubility (25°C)
| In vitro | Water | 100 mg/mL warmed (109.17 mM) |
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| DMSO | 30 mg/mL warmed (32.75 mM) | |
| Ethanol | 9 mg/mL warmed (9.82 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 915.98 |
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| Formula | C24H29N5O3.C24H29NO5.5/2H2O.3Na |
| CAS No. | 936623-90-4 |
| Storage | powder |
| in solvent | |
| Synonyms | Sacubitril, Valsartan |
| Smiles | [Na+].[Na+].[Na+].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[NH]3)C(C(C)C)C(O)=O.CCOC(=O)C(C)CC(CC4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)CCC(O)=O |
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Clinical Trial Information
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
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| NCT02690974 | Completed | Drug: LCZ696 (sacubitril/valsartan) | Hearth Failure With Reduced Ejection Fraction (HFrEF) | Novartis Pharmaceuticals|Novartis | March 8 2016 | Phase 4 |
| NCT02661217 | Completed | Drug: LCZ696 | Heart Failure With Reduced Ejection Fraction | Novartis Pharmaceuticals|Novartis | February 12 2016 | Phase 4 |
| NCT02226120 | Completed | Drug: LCZ696 | Chronic Heart Failure With Reduced Ejection Fraction | Novartis Pharmaceuticals|Novartis | October 16 2014 | Phase 3 |
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