Sacubitril/valsartan (LCZ696)
Catalog No.S7678 Synonyms: Sacubitril, Valsartan
Molecular Weight(MW): 915.98
Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
Cited by 2 Publications
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Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (***P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (*P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (***P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (**P < 0.01, n = 7 per group).
J Mol Cell Cardiol, 2017, 108:138-148. Sacubitril/valsartan (LCZ696) purchased from Selleck.
Representative H&E stain of heart sections from (A) sham-operated group, (B) model group, (C) LCZ696-treated group. Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×100).
RSC Adv, 2017, doi:10.1039/C7RA01404J. Sacubitril/valsartan (LCZ696) purchased from Selleck.
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Biological Activity
| Description | Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3. | |
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| In vivo | In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. [1] In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. [2] |
Protocol
| Animal Research: |
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Solubility (25°C)
| In vitro | Water | 100 mg/mL warmed (109.17 mM) |
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| DMSO | 30 mg/mL warmed (32.75 mM) | |
| Ethanol | 9 mg/mL warmed (9.82 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 915.98 |
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| Formula | C24H29N5O3.C24H29NO5.5/2H2O.3Na |
| CAS No. | 936623-90-4 |
| Storage | powder |
| in solvent | |
| Synonyms | Sacubitril, Valsartan |
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Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03760588 | Recruiting | Breast Cancer Female|Heart Failure | Torbjorn Omland|University Hospital Akershus|Oslo University Hospital|University Hospital of North Norway|St. Olavs Hospital|Helse Stavanger HF|KLINBEFORSK|Norwegian Cancer Society|Novartis | January 14 2019 | Phase 2 |
| NCT03760588 | Recruiting | Breast Cancer Female|Heart Failure | Torbjorn Omland|University Hospital Akershus|Oslo University Hospital|University Hospital of North Norway|St. Olavs Hospital|Helse Stavanger HF|KLINBEFORSK|Norwegian Cancer Society|Novartis | January 14 2019 | Phase 2 |
| NCT03771729 | Not yet recruiting | CKD | The Second Affiliated Hospital of Harbin Medical University | December 30 2018 | Early Phase 1 |
| NCT03771729 | Not yet recruiting | CKD | The Second Affiliated Hospital of Harbin Medical University | December 30 2018 | Early Phase 1 |
| NCT03738878 | Recruiting | Hypertension | Vanderbilt University Medical Center | November 15 2018 | Phase 4 |
| NCT03738878 | Recruiting | Hypertension | Vanderbilt University Medical Center | November 15 2018 | Phase 4 |
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