Sacubitril/valsartan (LCZ696)
Catalog No.S7678 Synonyms: Sacubitril, Valsartan
Molecular Weight(MW): 915.98
Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
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Histological analysis staining of three groups. (a) Representative H&E-staining micrographs displaying transverse myocardial section (original magnification ×200). (b) Masson staining of three groups (original magnification ×200). Collagen content (%) of heart tissues were presented as fibrosis (***P < 0.001, n = 7 per group). (c) Cardiac section of three group mice hearts stained with WGA (original magnification ×400) (*P < 0.05, n = 7 per group). (d) The expression of Drp1 significantly increased in DOX group (***P < 0.001, n = 7 per group) and it decreased in DOX + LCZ696 group (**P < 0.01, n = 7 per group).
J Mol Cell Cardiol, 2017, 108:138-148. Sacubitril/valsartan (LCZ696) purchased from Selleck.
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Biological Activity
| Description | Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3. | |
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| In vivo | In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. [1] In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. [2] |
Protocol
| Animal Research: |
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Solubility (25°C)
| In vitro | Water | 100 mg/mL warmed (109.17 mM) |
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| DMSO | 30 mg/mL warmed (32.75 mM) | |
| Ethanol | 9 mg/mL warmed (9.82 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 915.98 |
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| Formula | C24H29N5O3.C24H29NO5.5/2H2O.3Na |
| CAS No. | 936623-90-4 |
| Storage | powder |
| in solvent | |
| Synonyms | Sacubitril, Valsartan |
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Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02690974 | Completed | Hearth Failure With Reduced Ejection Fraction (HFrEF) | Novartis Pharmaceuticals|Novartis | March 8 2016 | Phase 4 |
| NCT02678312 | Recruiting | Pediatric Heart Failure | Novartis Pharmaceuticals|Novartis | November 3 2016 | Phase 2|Phase 3 |
| NCT02884206 | Recruiting | Chronic Heart Failure (CHF) | Novartis Pharmaceuticals|Novartis | November 23 2016 | Phase 3 |
| NCT01865188 | Withdrawn | Hypertension | Novartis Pharmaceuticals|Novartis | April 2014 | Phase 3 |
| NCT01922089 | Completed | Heart Failure With Reduced Ejection Fraction | Novartis Pharmaceuticals|Novartis | November 2013 | Phase 2 |
| NCT01870739 | Completed | Hypertension | Novartis Pharmaceuticals|Novartis | October 2013 | Phase 2 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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