Home Metabolism HMG-CoA Reductase inhibitor Simvastatin acid (ammonium)

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Simvastatin acid (ammonium) HMG-CoA Reductase inhibitor

Cat.No.E4821

Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). This compound also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes and regulates the expression of OATP3A1 in these cells.
Simvastatin acid (ammonium) HMG-CoA Reductase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 453.61

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Quality Control

Batch: E482101 DMSO]15 mg/mL]false]Ethanol]5 mg/mL]false]Water]2 mg/mL]false Purity: 99.01%
99.01

Solubility

In vitro
Batch:

DMSO : 15 mg/mL (33.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : 2 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 453.61 Formula

C25H40O6.H3N

 Storage (From the date of receipt)
CAS No. 139893-43-9 Download SDF Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
HMG-CoA reductase
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06209359 RECRUITING
Heart Failure; Diuretic Resistance
Yale University
 2024-07-24 PHASE1
NCT06637826 ACTIVE_NOT_RECRUITING
Healthy
National Natural Science Foundation of China
 2024-10-01 EARLY_PHASE1
NCT05639907 RECRUITING
Inflammation Caused by the Placement of a Temporary Anchorage Device
University of Colorado, Denver
 2022-11-11
NCT07722351 COMPLETED
Skin Aging; Hyperpigmentation
Medical University of Silesia
 2025-10-29
NCT05247567 TERMINATED
Quaternary Ammonium; Hypersensitivity
Assistance Publique - Hôpitaux de Paris
 2022-10-27
NCT04742660 COMPLETED
Postoperative Nausea
Konkuk University Medical Center
 2021-05-11

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