SU14813

Catalog No.S0504 Synonyms: SU 014813

For research use only.

SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.

SU14813 Chemical Structure

CAS No. 627908-92-3

Selleck's SU14813 has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.
Targets
VEGFR1 [1]
(Cell-free assay)
PDGFRβ [1]
(Cell-free assay)
KIT [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
2 nM 4 nM 15 nM 50 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 88 mg/mL
(198.87 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 442.48
Formula

C23H27FN4O4

CAS No. 627908-92-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(NC(=C1C(=O)NCC(CN2CCOCC2)O)C)C=C3C4=C(C=CC(=C4)F)NC3=O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00322517 Completed Drug: SU014813 Breast Neoplasms Pfizer April 2006 Phase 2
NCT00982267 Completed Drug: SU014813 Neoplasms|Solid Tumors Pfizer December 2003 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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