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Suramin sodium salt phosphatase inhibitor

Name: Suramin sodium salt
Brand: Selleck Chemicals
SKU: S8942
Availability: InStock
Rating: 5 (3 reviews)

Cat.No.S8942

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).

Chemical Structure

Molecular Weight: 1435.23

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Quality Control

Batch: S894201 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]Insoluble]false Purity: 99.87%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS/MSDS
Datasheet

99.87

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase
Other phosphatase Inhibitors	Osunprotafib (ABBV-CLS-484) SHP099 Hydrochloride RMC-4550 SHP099 Batoprotafib (TNO155) GSK2830371 β-Glycerophosphate sodium salt hydrate NSC87877 TPI-1 Sanguinarine chloride

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (69.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (3.48mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.625mg/ml (0.44mM)	Taking the 1 mL working solution as an example, add 50 μL of 12.5 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1435.23	Formula	C₅₁H₄₀N₆O₂₃S₆.6Na	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	129-46-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Suramin hexasodium salt			SMILES	CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Yersinia PTPase Yersinia PTP1B RdRp (in solution based assays) 0.26 μM SirT1 (in the a fluorescent deacetylase assay) 297 nM SirT2 (in the a fluorescent deacetylase assay) 1.15 μM Topoisomerase II (in either decatenation or relaxation assays) 5 μM SirT5 (in the a fluorescent deacetylase assay) 22 μM
References	[1] https://pubmed.ncbi.nlm.nih.gov/9575179/ [2] https://pubmed.ncbi.nlm.nih.gov/17628866/ [3] https://pubmed.ncbi.nlm.nih.gov/1313577/ [4] https://pubmed.ncbi.nlm.nih.gov/33674802/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-30)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06866275	RECRUITING	Autism Spectrum Disorder (ASD)	Children's Hospital of Orange County	2025-04-09	PHASE2
NCT04496596	UNKNOWN	Acute Kidney Injury	Rediscovery Life Sciences	2020-11-13	PHASE2
NCT06058962	COMPLETED	Autism Spectrum Disorder	Paxmedica	2019-06-01	PHASE2
NCT03804749	UNKNOWN	Hand, Foot and Mouth Disease	First Affiliated Hospital of Zhejiang University	2018-12-19	PHASE1
NCT02508259	COMPLETED	Autism Spectrum Disorders	University of California, San Diego	2015-05	PHASE1; PHASE2
NCT01671332	COMPLETED	Carcinoma, Non Small Cell Lung	University of Wisconsin, Madison	2012-06	PHASE2

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