Simethicone | inhibitor | Highly Cited | In Stock

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Batch: E014701 Purity: 99%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99

Related Targets	PROTAC Others Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell Antibiotics for Mammalian Cell Culture ADC Linker Molecular Glues Hydrotropic Agents
Other Inhibitors	ISX-9 (Isoxazole 9) YAP-TEAD Inhibitor 1 (Peptide 17) L-Buthionine-(S,R)-sulfoximine (L-BSO) PF-3644022 WAY-641966 WAY-320461

Solubility

In vitro
Batch:

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	N/A	Formula	(C₂H₆OSi)n•(SiO₂)m	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	8050-81-5	--		Storage (From the date of receipt)	2 years -20°C liquid

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://www.sciencedirect.com/science/article/pii/B9781416036616000158

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-29)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07674160	NOT_YET_RECRUITING	Quality of Bowel Preparation	Dalin Tzu Chi General Hospital	2026-08-01
NCT07696793	RECRUITING	Colorectal Cancer Early Detection	Fundacion Clinic per a la Recerca Biomédica	2026-05-18	PHASE4
NCT06812832	RECRUITING	Simethicone; Bariatric Surgery; Post-operative Pain	Madigan Army Medical Center	2025-04-08	PHASE4
NCT06919120	NOT_YET_RECRUITING	Colonoscopy	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	2025-06-01	PHASE4
NCT07501962	NOT_YET_RECRUITING	Colonoscopy	The First Affiliated Hospital of Zhengzhou University	2026-04-01
NCT07245095	RECRUITING	Esophagogastroduodenoscopy; Simethicone; N-Acetylcysteine; Premedication; Visualization; Esophagogastroduodensocopy (EGD) Procedure; Placebo - Control; Gastritis Associated With Helicobacter Pylori; Tumor Gastric; Lesions in the Esophagus, Stomach, Duodenum or Rectum	Hospital General de Mexicali	2025-09-12	PHASE2

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Simethicone inhibitor

Chemical Structure

Molecular Weight: N/A