SRT3025 HCl
Catalog No.S8481

Molecular Weight(MW): 606.2
SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.
Purity & Quality Control
Choose Selective Sirtuin Inhibitors
Biological Activity
Description | SRT3025 is an orally available small molecule activator of the SIRT1 enzyme. | |
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Targets |
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In vitro |
SRT3025 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT3025 inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages (BMMs) by activating AMPK and deacetylating RelA/p65 lysine 310, critical for activation of the NF-κB signaling pathway[2]. SRT3025 acts faster than oxymetholone to improve hematopoiesis. It does not work by direct activation of Sirt1 in hematopoietic cells. SRT3025 might suppress p21 transcription through the down-regulation of Egr1[3]. SRT3025 is found to activate wild-type Sirt1 protein but failed to activate the E230K mutant, an activation-resistant Sirt1 protein (due to a mutation at position 230)[4]. |
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In vivo | SRT3025 treatment also inhibits tumor growth in Panc-1 xenografts, even though it is not as effective in inhibiting the viability of Panc-1 cells in culture. SRT3025 is well tolerated in mice and has the potential to be used in several diseases[1]. SRT3025 administration expands HSPCs and boosts blood counts while long term SRT3025 administration does not permanently increase or decrease HSC repopulating potential[3]. SRT3025 reduces plasma cholesterol, inflammation, and atherosclerosis in Apoe−/− mice, and it increases hepatic Ldlr expression and Pcsk9 accumulation[4]. |
Protocol
Cell Research: |
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Animal Research: |
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Solubility (25°C)
In vitro | DMSO | 100 mg/mL warmed (164.96 mM) |
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Ethanol | 5 mg/mL warmed (8.24 mM) | |
Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 606.2 |
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Formula | C31H31N5O2S2.HCl |
CAS No. | 2070015-26-6 |
Storage | powder |
in solvent | |
Synonyms | N/A |
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