Home Proteases MALT inhibitor Safimaltib For research use only.

Safimaltib

Synonyms: JNJ-6633, JNJ-67856633

Safimaltib(JNJ-67856633,JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.

Safimaltib Chemical Structure

Safimaltib Chemical Structure

CAS: 2230273-76-2

Selleck's Safimaltib has been cited by 1 publication

Purity & Quality Control

Batch: S989601 DMSO] 93 mg/mL] false] Ethanol] 93 mg/mL] false] Water] Insoluble] false Purity: 99.91%
99.91

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Biological Activity

Description Safimaltib(JNJ-67856633,JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.
Targets
MALT1 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04876092 Active not recruiting
Leukemia Lymphocytic Chronic B-Cell|Lymphoma Non-Hodgkin
Janssen Research & Development LLC
 July 28 2021 Phase 1
NCT04657224 Active not recruiting
Lymphoma Non-Hodgkin|Chronic Lymphocytic Leukemia
Janssen Research & Development LLC
 February 25 2021 Phase 1
NCT03900598 Active not recruiting
Leukemia Lymphocytic Chronic B-Cell|Lymphoma Non-Hodgkin
Janssen Research & Development LLC
 April 3 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 467.32 Formula

C20H11F6N5O2
CAS No. 2230273-76-2 SDF --
Smiles FC(F)(F)C1=NC=CC(=C1)NC(=O)C2=C([N](N=C2)C3=CC=CC4=C3C=CNC4=O)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 93 mg/mL ( (199.0 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 93 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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