Safimaltib | MALT inhibitor | CAS 2230273-76-2

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Quality Control

Batch: S989601 DMSO]93 mg/mL]false]Ethanol]93 mg/mL]false]Water]Insoluble]false Purity: 99.91%

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COA
NMR
SDS
Datasheet

99.91

Related Targets	HDAC Caspase Proteasome Secretase MMP HCV Protease Cysteine Protease DPP Tyrosinase HIV Protease
Other MALT Inhibitors	MI-2 (MALT1 inhibitor) MLT-748 Mepazine hydrochloride

Solubility

In vitro
Batch:

DMSO : 93 mg/mL (199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 93 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	467.32	Formula	C₂₀H₁₁F₆N₅O₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2230273-76-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	JNJ-6633, JNJ-67856633			Smiles	FC(F)(F)C1=NC=CC(=C1)NC(=O)C2=C([N](N=C2)C3=CC=CC4=C3C=CNC4=O)C(F)(F)F

Mechanism of Action

Targets/IC₅₀/Ki	MALT1
References	[1] https://cancerres.aacrjournals.org/content/80/16_Supplement/5690.short

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04876092	Active not recruiting	Leukemia Lymphocytic Chronic B-Cell\|Lymphoma Non-Hodgkin	Janssen Research & Development LLC	July 28 2021	Phase 1
NCT04657224	Active not recruiting	Lymphoma Non-Hodgkin\|Chronic Lymphocytic Leukemia	Janssen Research & Development LLC	February 25 2021	Phase 1
NCT03900598	Active not recruiting	Leukemia Lymphocytic Chronic B-Cell\|Lymphoma Non-Hodgkin	Janssen Research & Development LLC	April 3 2019	Phase 1

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Safimaltib MALT inhibitor

Chemical Structure

Molecular Weight: 467.32