SRX3207

Catalog No.S8948

For research use only.

SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.

SRX3207 Chemical Structure

CAS No. 2254693-15-5

Purity & Quality Control

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Biological Activity

Description SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
Targets
Syk [1]
(cell-free assay)
PI3K alpha [1]
(cell-free assay)
PI3K delta [1]
(cell-free assay)
BRD41 [1]
(cell-free assay)
BRD42 [1]
(cell-free assay)
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39.9 nM 244 nM 388 nM 3070 nM 3070 nM
In vivo

SRX3207 blocks both PI3K and Syk in MΦs thereby activating innate and adaptive antitumor immunity in vivo.[1]

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Floxed Syk mice, lysozyme M (LysM) Cre recombinase transgenic mice
  • Dosages: 5 mg/kg, 15 mg/kg
  • Administration: IV, PO

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 555.65
Formula

C29H29N7O3S

 

CAS No. 2254693-15-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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