Home Angiogenesis Syk inhibitor SRX3207

research use only

SRX3207 Syk inhibitor

Cat.No.S8948

SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. This compound blocks tumor immunosuppression and increases anti-tumor immunity.
SRX3207 Syk inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 555.65

Jump to

Quality Control

Batch: S894801 DMSO]33 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.76%
99.76

Solubility

In vitro
Batch:

DMSO : 33 mg/mL (59.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 555.65 Formula

C29H29N7O3S

 

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2254693-15-5 -- Storage of Stock Solutions

Synonyms N/A Smiles CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7

Mechanism of Action

Targets/IC50/Ki
Syk
(cell-free assay)
39.9 nM
PI3K alpha
(cell-free assay)
244 nM
PI3K delta
(cell-free assay)
388 nM
BRD41
(cell-free assay)
3070 nM
BRD42
(cell-free assay)
3070 nM
PI3K gamma
(cell-free assay)
9790 nM
ZAP70
(cell-free assay)
31200 nM
In vivo

This compound blocks both PI3K and Syk in MΦs thereby activating innate and adaptive antitumor immunity in vivo.
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map