SR1078

Catalog No.S5775

SR1078 Chemical Structure

Molecular Weight(MW): 431.25

SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.

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Biological Activity

Description SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.
Targets
RORα [1]
()
RORγ [1]
()
In vitro

SR1078 modulates the conformation of RORγ in a biochemical assay and activates RORα and RORγ driven transcription. SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both RORα and RORγ[1].

In vivo SR1078 displays pharmacokinetic properties that allow it to be used in vivo[1].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: HepG2 cells
  • Concentrations: 10 μM
  • Incubation Time: 24 h
  • Method:

    --


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: C57BL6 mice
  • Formulation: --
  • Dosages: 10 mg/kg
  • Administration: I.P.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 86 mg/mL (199.42 mM)
Ethanol 86 mg/mL (199.42 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 431.25
Formula

C17H10F9NO2

CAS No. 1246525-60-9
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID