Home Apoptosis Ferroptosis inhibitor SRS16-86

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SRS16-86 Ferroptosis inhibitor

Cat.No.S9840

SRS16-86, a novel third-generation ferrostatin, is an inhibitor of ferroptosis.
SRS16-86 Ferroptosis inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 432.56

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S984001 DMSO]2 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 98.73%
98.73

Chemical Information, Storage & Stability

Molecular Weight 432.56 Formula

C26H32N4O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1793052-96-6 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(C)(C)OC(=O)C1=CC(=C(NC23CC4CC(CC(C4)C2)C3)C=C1)N=CC5=CN=CN=C5

Solubility

In vitro
Batch:

DMSO : 2 mg/mL (4.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

SRS16-86 exhibits ferroptosis-inhibiting ability in vitro by FACS analysis of erastin-treated HT-1080 cells and in NIH 3T3 cells.[1]
In vivo

SRS16-86 (a novel third-generation ferrostatin) is more stable, to metabolism and plasma, and more potent, compared with the first-in-class compound ferrostatin-1 (Fer-1) to suppress ferroptosis in vivo. Even in conditions with extraordinarily severe IRI, this compound exerts strong protection to an extent which has not previously allowed survival in any murine setting.[1]
References

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