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Apoptosis related

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP
Cat.No. Product Name Information Product Use Citations Product Validations
S3654 Tauroursodeoxycholic Acid (TUDCA) Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).
Nat Commun, 2025, 16(1):50
Toxicol Appl Pharmacol, 2025, 499:117333
Cell Mol Life Sci, 2024, 81(1):299
S1378 Ruxolitinib (INCB18424) Ruxolitinib (INCB18424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. This compound kills tumor cells through toxic mitophagy. It induces autophagy and enhances apoptosis.
Nature, 2025, 10.1038/s41586-025-08938-8
Nat Commun, 2025, 16(1):8409
Nat Commun, 2025, 16(1):492
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S7818 Pexidartinib (PLX3397) Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. This compound induces apoptosis and necrosis with antitumor activity. Phase 3.
Nat Commun, 2025, 16(1):6779
Nat Commun, 2025, 16(1):4590
Mol Ther, 2025, S1525-0016(25)00871-8
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S2673 Trametinib (GSK1120212) Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, and it does not inhibit the kinase activities of c-Raf, B-Raf, ERK1/2. This compound activates autophagy and induces apoptosis.
Cancer Cell, 2025, S1535-6108(25)00271-5
Signal Transduct Target Ther, 2025, 10(1):161
Signal Transduct Target Ther, 2025, 10(1):299
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S1237 TMZ(Temozolomide) Temozolomide (TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. It is a DNA damage inducer in L-1210 and L-1210/BCNU cells. This compound induces apoptosis and exhibits antitumor activity.
Cancer Cell, 2025, S1535-6108(25)00223-5
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2025, 16(1):5676
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S1120 RAD001 (Everolimus) Everolimus is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2025, 16(1):8189
Cell Rep Med, 2025, 6(11):102425
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S1413 Bafilomycin A1 (Baf-A1) Bafilomycin A1 (Baf-A1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM, and it is found to inhibit autophagy while inducing apoptosis.
Nature, 2025, 10.1038/s41586-025-09745-x
Cell Res, 2025, 10.1038/s41422-025-01085-9
Signal Transduct Target Ther, 2025, 10(1):81
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S1021 Dasatinib (BMS-354825) Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.
Cancer Cell, 2025, S1535-6108(25)00070-4
Mil Med Res, 2025, 12(1):83
Nat Commun, 2025, 16(1):4069
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S2215 DAPT DAPT is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.
Signal Transduct Target Ther, 2025, 10(1):334
Cell Host Microbe, 2025, 33(3):408-419.e8
Nat Commun, 2025, 16(1):8693
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S1208 Doxorubicin (Adriamycin) Hydrochloride Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase II with IC50 of 2.67 μM. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution.Doxorubicin (Adriamycin) HCl can be used to induce animal models of kidney disease.
Cell Res, 2025, 35(6):437-452.
Nat Commun, 2025, 16(1):8873
Nat Commun, 2025, 16(1):509
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