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RGD peptide (GRGDNP) Integrin inhibitor

Name: RGD peptide (GRGDNP)
Brand: Selleck Chemicals
SKU: S4513
Availability: InStock
Rating: 5 (5 reviews)

Cat.No.S4513

RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. This compound induces apoptosis presumably through direct activation of caspase-3.

RGD peptide (GRGDNP) Integrin inhibitor Chemical Structure

Quality Control

Batch: Purity: 99.91%

99.91

Related Targets	Akt Wnt/beta-catenin PKC HSP ROCK Microtubule Associated Bcr-Abl Actin FAK Kinesin
Other Integrin Inhibitors	SB273005 Cilengitide trifluoroacetate Cilengitide (EMD 121974) RGD peptide (Arg-Gly-Asp) ATN-161 Cyclo(RGDyK) TFA Cyclo(-RGDfK) TFA Leukadherin-1 A-205804 Pyrintegrin

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	614.61	Formula	C₂₃H₃₈N₁₀O₁₀	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	114681-65-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			SMILES	NCC(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)N1CCCC1C(O)=O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	integrin caspase-3
In vitro	RGD peptide (GRGDNP) interfers with cell proliferation by affecting cell protrusion and stress fibers.
References	[1] https://pubmed.ncbi.nlm.nih.gov/22846566/ [2] https://pubmed.ncbi.nlm.nih.gov/19089540/ [3] https://pubmed.ncbi.nlm.nih.gov/30538450/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-04-20)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06936605	NOT_YET_RECRUITING	Intrabony Defect; Periodontal Diseases; Alveolar Bone Loss	Minia University	2025-04-15
NCT05653245	COMPLETED	Periodontitis	Minia University	2021-03-15	PHASE1; PHASE2
NCT03974685	COMPLETED	Healthy	RDO Pharm.	2018-12-12	PHASE1

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